Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/YoeB-RelB
Location 1678489..1679005 Replicon chromosome
Accession NZ_CP093332
Organism Buttiauxella ferragutiae strain H4-C11

Toxin (Protein)


Gene name relB Uniprot ID A0A3G2IJE2
Locus tag MNO13_RS07640 Protein ID WP_064545091.1
Coordinates 1678736..1679005 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag MNO13_RS07635 Protein ID WP_133521914.1
Coordinates 1678489..1678752 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNO13_RS07620 (MNO13_07620) 1674424..1675536 + 1113 WP_064545083.1 iron-sulfur cluster carrier protein ApbC -
MNO13_RS07625 (MNO13_07625) 1676022..1677710 + 1689 WP_133522074.1 sensor histidine kinase -
MNO13_RS07630 (MNO13_07630) 1677704..1678432 + 729 WP_064545087.1 two-component system response regulator BtsR -
MNO13_RS07635 (MNO13_07635) 1678489..1678752 + 264 WP_133521914.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
MNO13_RS07640 (MNO13_07640) 1678736..1679005 + 270 WP_064545091.1 Txe/YoeB family addiction module toxin Toxin
MNO13_RS07645 (MNO13_07645) 1679074..1679544 + 471 WP_064545093.1 DUF1456 family protein -
MNO13_RS07650 (MNO13_07650) 1679590..1680558 - 969 WP_241939705.1 XdhC family protein -
MNO13_RS07655 (MNO13_07655) 1680545..1681135 - 591 WP_241940049.1 nucleotidyltransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(10-89)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10747.17 Da        Isoelectric Point: 8.0291

>T238159 WP_064545091.1 NZ_CP093332:1678736-1679005 [Buttiauxella ferragutiae]
MKTTNRLLAWTDHAWDDYLWWQTQDRKTLKRINKLIEDAQRNPFDGLGKPEPLRENLSGLWSRRINEADRLVYSVSDDLL
TIFQCRLHY

Download         Length: 270 bp

>T238159 NZ_LR890240:c2608316-2606994 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
CAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTTTCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9831.07 Da        Isoelectric Point: 4.2336

>AT238159 WP_133521914.1 NZ_CP093332:1678489-1678752 [Buttiauxella ferragutiae]
MQVITFSEARNRLKTVLDDVVDNADITVITRRDAEDAVVMSLDYYNSLMETVHLLSSPANATRLMESMAQVQAGKISRRE
IIDEDNE

Download         Length: 264 bp

>AT238159 NZ_LR890240:c2608582-2608316 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G2IJE2

Antitoxin

Source ID Structure

References