Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 862568..863237 Replicon chromosome
Accession NZ_CP093332
Organism Buttiauxella ferragutiae strain H4-C11

Toxin (Protein)


Gene name cptA Uniprot ID A0A3G2IIE9
Locus tag MNO13_RS03970 Protein ID WP_064543659.1
Coordinates 862815..863237 (+) Length 141 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A1B7I271
Locus tag MNO13_RS03965 Protein ID WP_064513590.1
Coordinates 862568..862834 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNO13_RS03945 (MNO13_03945) 858012..859445 - 1434 WP_064543649.1 6-phospho-beta-glucosidase -
MNO13_RS03950 (MNO13_03950) 859611..860339 - 729 WP_064543652.1 MurR/RpiR family transcriptional regulator -
MNO13_RS03955 (MNO13_03955) 860529..861182 + 654 WP_064543654.1 hemolysin III family protein -
MNO13_RS03960 (MNO13_03960) 861334..862320 - 987 WP_064543657.1 tRNA-modifying protein YgfZ -
MNO13_RS03965 (MNO13_03965) 862568..862834 + 267 WP_064513590.1 FAD assembly factor SdhE Antitoxin
MNO13_RS03970 (MNO13_03970) 862815..863237 + 423 WP_064543659.1 protein YgfX Toxin
MNO13_RS03975 (MNO13_03975) 863245..863766 - 522 WP_064543777.1 flavodoxin FldB -
MNO13_RS03980 (MNO13_03980) 863880..864776 + 897 WP_074388528.1 site-specific tyrosine recombinase XerD -
MNO13_RS03985 (MNO13_03985) 864801..865517 + 717 WP_241939556.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
MNO13_RS03990 (MNO13_03990) 865525..867258 + 1734 WP_241939557.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 16644.59 Da        Isoelectric Point: 11.2010

>T238158 WP_064543659.1 NZ_CP093332:862815-863237 [Buttiauxella ferragutiae]
VVLWQSDLRVSWRAQWLSLLVHGLVALFVLLMPWPMSYTLIWMLLLSLVVFDSVRSQRRIHACQGEMKLLTDYHLRWQNQ
EWEMVGAPWVLRSGMMLRLRRVGRKRSQHLWLSADSMDTGEWRDLRRLMLQQQASGNGEV

Download         Length: 423 bp

>T238158 NZ_LR890240:2372868-2373185 [Klebsiella pneumoniae]
ATGTTGACTTTTATTGAACTACAAGGTTTCAGTAAGCGACGCCAGGTGCTGTTGCAGGATGATGAATTTCGGGCCTTTCA
GGAAATCCTTATAAACGATCCCGAGGCTGGGGACACAATTTCGGGAACCGGTGGTTTTCGTAAAATTCGCTGGAGTCGTC
CCGGGATGGGGAAGCGCGGCGGTGTACGAGTGATTTACTATAATGTAACGAAAAAGGGAAGAATTTACCTGGCGCTCATC
TATCCTAAAAATGAACAGGATGAGTTAAATCAGGAGCAAAAAAAGATGTTGAGACAAGTGGCTGATTTAATAAACTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10471.97 Da        Isoelectric Point: 5.1238

>AT238158 WP_064513590.1 NZ_CP093332:862568-862834 [Buttiauxella ferragutiae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSTEDKQLFVRLLESDDPDLFNWLMNHGKPADTELQRMVTLIQTRN
KERGPVAI

Download         Length: 267 bp

>AT238158 NZ_LR890240:2373261-2373557 [Klebsiella pneumoniae]
ATGAAAGACGAATTGTTTGCCGATCTGCTGGCGAGTGCAGAAGAAATGGTCAGGATCGAGAAAGGTGAACAAATGCCGAT
GGAGCAGCACGTTCATACCTTCAGCGAAATTGACGTGAAAGCGATACGTGAAGCCACAGGTTTAAAACAGCAGGACTTTG
CAGCGGCCGTTGGCGTTAGCTACGAGTTGGTTAAAAGCTGGGAAACGAAACGACGTCAGCCAACCGGTGCAGCCAGAAAA
CTGCTTTTATTGCTTCAGGGTAATCCATTGATTATCAACTTGTTGAAGGTTGTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G2IIE9

Antitoxin

Source ID Structure
AlphaFold DB A0A1B7I271

References