Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 542307..544126 Replicon plasmid p2
Accession NZ_CP093330
Organism Rahnella aceris strain S2-A69

Toxin (Protein)


Gene name hipA Uniprot ID H8P0A1
Locus tag MNO10_RS24970 Protein ID WP_013578107.1
Coordinates 542307..543656 (+) Length 450 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID H8P0A0
Locus tag MNO10_RS24975 Protein ID WP_013578106.1
Coordinates 543653..544126 (+) Length 158 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNO10_RS24935 (MNO10_24935) 537736..538035 - 300 Protein_509 iron dicitrate ABC transporter ATP-binding protein -
MNO10_RS24940 (MNO10_24940) 538194..538412 - 219 WP_013578112.1 YgdI/YgdR family lipoprotein -
MNO10_RS24945 (MNO10_24945) 538791..539165 + 375 WP_051930969.1 hypothetical protein -
MNO10_RS24950 (MNO10_24950) 539278..540603 + 1326 WP_168444347.1 heme anaerobic degradation radical SAM methyltransferase ChuW/HutW -
MNO10_RS24955 (MNO10_24955) 540581..541102 + 522 WP_241917389.1 heme utilization cystosolic carrier protein HutX -
MNO10_RS24960 (MNO10_24960) 541099..541722 + 624 WP_014416649.1 NAD(P)H-binding protein -
MNO10_RS24965 (MNO10_24965) 541890..542111 + 222 WP_014416648.1 DUF1471 domain-containing protein -
MNO10_RS24970 (MNO10_24970) 542307..543656 + 1350 WP_013578107.1 HipA domain-containing protein Toxin
MNO10_RS24975 (MNO10_24975) 543653..544126 + 474 WP_013578106.1 helix-turn-helix transcriptional regulator Antitoxin
MNO10_RS24980 (MNO10_24980) 544187..544507 - 321 WP_013578105.1 multidrug efflux SMR transporter -
MNO10_RS24985 (MNO10_24985) 544623..545477 - 855 WP_014416647.1 LysR family transcriptional regulator -
MNO10_RS24990 (MNO10_24990) 545565..546278 - 714 WP_112151437.1 DUF554 domain-containing protein -
MNO10_RS24995 (MNO10_24995) 546318..546887 - 570 WP_121019887.1 UbiX family flavin prenyltransferase -
MNO10_RS25000 (MNO10_25000) 546947..548446 - 1500 WP_013578103.1 UbiD family decarboxylase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(166-381)

Antitoxin

(84-139)


Sequences


Toxin        


Download         Length: 450 a.a.        Molecular weight: 51261.71 Da        Isoelectric Point: 4.7025

>T238157 WP_013578107.1 NZ_CP093330:542307-543656 [Rahnella aceris]
MEFLTLQAFLNNTWVDIANITFPGSEQNNYRLTELNYHSDYAIDNLDRDDNHAASLNHPVSLFFDGDDERGWLKFLDDII
PSGSSRRYWANYLDLEGLTADQQNFILLKHGTLSPVGNLRIKESLPEYNPLAEKLFFTIEDVKNRAGDFLDYAQQRGAAA
GGATGAGGEAPKLLLRCSQEQQIWIDTYQNDTANRDIPYLVKYPRGARTEVDCNILRAEFYFYHELEAMGFDTIPTQNMR
LEEGLTYPSLWLPRFDISFEEEGLIRRFGMESVYSLLRKAPGVTLYHEETLRALIDKISHSHMVTEQGFDFDIPGFVTEW
VRRDLLNIIFGNSDNHGRNTSFLKDERSIRLAPIYDFAPMKADPEGIARTTKWKAPLEIGGEYDYPGIAQSLDDLVPAET
LLSALKNTSHQLSGLKERLEARGIPQQILNMPAISFSFIPEKLRRWGLL

Download         Length: 1350 bp

>T238157 NZ_LR890240:1886593-1886695 [Klebsiella pneumoniae]
GCAAGGCGGCTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 158 a.a.        Molecular weight: 17587.18 Da        Isoelectric Point: 10.9653

>AT238157 WP_013578106.1 NZ_CP093330:543653-544126 [Rahnella aceris]
MKEPEIAANSARNTIDKIRAKQNEANHVRRDAGQMLAQEETSSTGKKQAQRRVSNLTKPVSTNDRNQARLDIMRALLLGE
ITQGQALKALRITVLGLKQDAFGKLVTVSRKTLSEVENDKGNYTPDIINKLFRPFGLKVGLVPVSQQIFRTLFERSE

Download         Length: 474 bp

>AT238157 NZ_LR890240:c1886702-1886557 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGCCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB H8P0A1


Antitoxin

Source ID Structure
AlphaFold DB H8P0A0

References