Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 542307..544126 Replicon plasmid p2
Accession NZ_CP093330
Organism Rahnella aceris strain S2-A69

Toxin (Protein)


Gene name hipA Uniprot ID H8P0A1
Locus tag MNO10_RS24970 Protein ID WP_013578107.1
Coordinates 542307..543656 (+) Length 450 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID H8P0A0
Locus tag MNO10_RS24975 Protein ID WP_013578106.1
Coordinates 543653..544126 (+) Length 158 a.a.

Genomic Context

MNO10_RS24945MNO10_RS24950MNO10_RS24955MNO10_RS24960MNO10_RS24965MNO10_RS24970MNO10_RS24975MNO10_RS24935MNO10_RS24940MNO10_RS24980MNO10_RS24985MNO10_RS24990MNO10_RS24995MNO10_RS25000
Location: 538791..539165 (375 bp)
Type: Others
Protein ID: WP_051930969.1
Location: 539278..540603 (1326 bp)
Type: Others
Protein ID: WP_168444347.1
Location: 540581..541102 (522 bp)
Type: Others
Protein ID: WP_241917389.1
Location: 541099..541722 (624 bp)
Type: Others
Protein ID: WP_014416649.1
Location: 541890..542111 (222 bp)
Type: Others
Protein ID: WP_014416648.1
Location: 542307..543656 (1350 bp)
Type: Toxin
Protein ID: WP_013578107.1
Location: 543653..544126 (474 bp)
Type: Antitoxin
Protein ID: WP_013578106.1
Location: 537736..538035 (300 bp)
Type: Others
Protein ID: Protein_509
Location: 538194..538412 (219 bp)
Type: Others
Protein ID: WP_013578112.1
Location: 544187..544507 (321 bp)
Type: Others
Protein ID: WP_013578105.1
Location: 544623..545477 (855 bp)
Type: Others
Protein ID: WP_014416647.1
Location: 545565..546278 (714 bp)
Type: Others
Protein ID: WP_112151437.1
Location: 546318..546887 (570 bp)
Type: Others
Protein ID: WP_121019887.1
Location: 546947..548446 (1500 bp)
Type: Others
Protein ID: WP_013578103.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
MNO10_RS24935 (MNO10_24935)537736..538035-300Protein_509iron dicitrate ABC transporter ATP-binding protein-
MNO10_RS24940 (MNO10_24940)538194..538412-219WP_013578112.1YgdI/YgdR family lipoprotein-
MNO10_RS24945 (MNO10_24945)538791..539165+375WP_051930969.1hypothetical protein-
MNO10_RS24950 (MNO10_24950)539278..540603+1326WP_168444347.1heme anaerobic degradation radical SAM methyltransferase ChuW/HutW-
MNO10_RS24955 (MNO10_24955)540581..541102+522WP_241917389.1heme utilization cystosolic carrier protein HutX-
MNO10_RS24960 (MNO10_24960)541099..541722+624WP_014416649.1NAD(P)H-binding protein-
MNO10_RS24965 (MNO10_24965)541890..542111+222WP_014416648.1DUF1471 domain-containing protein-
MNO10_RS24970 (MNO10_24970)542307..543656+1350WP_013578107.1HipA domain-containing proteinToxin
MNO10_RS24975 (MNO10_24975)543653..544126+474WP_013578106.1helix-turn-helix transcriptional regulatorAntitoxin
MNO10_RS24980 (MNO10_24980)544187..544507-321WP_013578105.1multidrug efflux SMR transporter-
MNO10_RS24985 (MNO10_24985)544623..545477-855WP_014416647.1LysR family transcriptional regulator-
MNO10_RS24990 (MNO10_24990)545565..546278-714WP_112151437.1DUF554 domain-containing protein-
MNO10_RS24995 (MNO10_24995)546318..546887-570WP_121019887.1UbiX family flavin prenyltransferase-
MNO10_RS25000 (MNO10_25000)546947..548446-1500WP_013578103.1UbiD family decarboxylase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-381)

Antitoxin

Cro/C1-type helix-turn-helix domain

(84-139)


Sequences

Toxin        


Download         Length: 450 a.a.        Molecular weight: 51261.71 Da        Isoelectric Point: 4.7025

>T238157 WP_013578107.1 NZ_CP093330:542307-543656 [Rahnella aceris]
MEFLTLQAFLNNTWVDIANITFPGSEQNNYRLTELNYHSDYAIDNLDRDDNHAASLNHPVSLFFDGDDERGWLKFLDDII
PSGSSRRYWANYLDLEGLTADQQNFILLKHGTLSPVGNLRIKESLPEYNPLAEKLFFTIEDVKNRAGDFLDYAQQRGAAA
GGATGAGGEAPKLLLRCSQEQQIWIDTYQNDTANRDIPYLVKYPRGARTEVDCNILRAEFYFYHELEAMGFDTIPTQNMR
LEEGLTYPSLWLPRFDISFEEEGLIRRFGMESVYSLLRKAPGVTLYHEETLRALIDKISHSHMVTEQGFDFDIPGFVTEW
VRRDLLNIIFGNSDNHGRNTSFLKDERSIRLAPIYDFAPMKADPEGIARTTKWKAPLEIGGEYDYPGIAQSLDDLVPAET
LLSALKNTSHQLSGLKERLEARGIPQQILNMPAISFSFIPEKLRRWGLL

Download         Length: 1350 bp

>T238157 NZ_LR890240:1886593-1886695 [Klebsiella pneumoniae]
GCAAGGCGGCTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 158 a.a.        Molecular weight: 17587.18 Da        Isoelectric Point: 10.9653

>AT238157 WP_013578106.1 NZ_CP093330:543653-544126 [Rahnella aceris]
MKEPEIAANSARNTIDKIRAKQNEANHVRRDAGQMLAQEETSSTGKKQAQRRVSNLTKPVSTNDRNQARLDIMRALLLGE
ITQGQALKALRITVLGLKQDAFGKLVTVSRKTLSEVENDKGNYTPDIINKLFRPFGLKVGLVPVSQQIFRTLFERSE

Download         Length: 474 bp

>AT238157 NZ_LR890240:c1886702-1886557 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGCCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBH8P0A1

Antitoxin

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Source
ID
Structure
AlphaFold DBH8P0A0

References