Detailed information of TA system TA238152

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 2829573..2830272
• Replicon: chromosome
• Accession: NZ_CP093328
• Organism: Rahnella aceris strain S2-A69

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: MNO10_RS12995
• Protein ID: WP_112198031.1
• Coordinates: 2829573..2830025 (-)
• Length: 151 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: -
• Locus tag: MNO10_RS13000
• Protein ID: WP_037035260.1
• Coordinates: 2830006..2830272 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MNO10_RS12975 (MNO10_12975)	2825465..2827198	-	1734	WP_013574113.1	single-stranded-DNA-specific exonuclease RecJ	-
MNO10_RS12980 (MNO10_12980)	2827205..2827924	-	720	WP_013574112.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
MNO10_RS12985 (MNO10_12985)	2827950..2828807	-	858	WP_049796146.1	site-specific tyrosine recombinase XerD	-
MNO10_RS12990 (MNO10_12990)	2829009..2829527	+	519	WP_013574110.1	flavodoxin FldB	-
MNO10_RS12995 (MNO10_12995)	2829573..2830025	-	453	WP_112198031.1	protein YgfX	Toxin
MNO10_RS13000 (MNO10_13000)	2830006..2830272	-	267	WP_037035260.1	FAD assembly factor SdhE	Antitoxin
MNO10_RS13005 (MNO10_13005)	2830551..2831543	+	993	WP_112152336.1	tRNA-modifying protein YgfZ	-
MNO10_RS13010 (MNO10_13010)	2831592..2832122	-	531	WP_013574106.1	class IV adenylate cyclase	-
MNO10_RS13015 (MNO10_13015)	2832307..2833251	+	945	WP_112152335.1	6-phosphofructokinase II	-
MNO10_RS13020 (MNO10_13020)	2833411..2833851	+	441	WP_013574104.1	DUF1198 domain-containing protein	-
MNO10_RS13025 (MNO10_13025)	2833978..2834865	+	888	WP_121020180.1	AraC family transcriptional regulator	-
MNO10_RS13030 (MNO10_13030)	2834930..2835265	-	336	WP_013574102.1	DUF2002 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-140)

Antitoxin

• Flavinator of succinate dehydrogenase (8-79)

Sequences

Toxin

Protein

• Length: 151 a.a.
• Molecular weight: 17574.91 Da
• Isoelectric Point: 11.6835

>T238152 WP_112198031.1 NZ_CP093328:c2830025-2829573 [Rahnella aceris]
VALWRCDLRVSWRSQLISLGCYGAVMLLILLAPWPAGYWPVWMTLLLLVLFECIRSQRRITARTGEMILLEDDRLLWRGH
EWQIKQPVWMISHGVLLSLRREKRKGGLAQAMRSSRQRLWLASDSMSLEEWRRLRQILLSGTPRSPVKPG

Nucleotide

• Length: 453 bp

>T238152 NZ_LR890236:24005-24475 [Klebsiella pneumoniae]
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
CTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACGGCATCACTAACGATGCTGGAGACGCTGGTACACCTGC
ATGCGGCACAGATAATGGACACTTTCACGCTACTGAGTATCGATGTGCCTGATGAACTGATCCAAAGCGCAAACATGGAT
GAATTACCGGACAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCTTGGTCATTTACCAGGAG
CTCGGTTGCTCTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAACTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10464.97 Da
• Isoelectric Point: 5.1236

>AT238152 WP_037035260.1 NZ_CP093328:c2830272-2830006 [Rahnella aceris]
MDINNRSRVHWACRRGMRELDISIMPFFEYEYDSLSETDKEVFVRLLTCDDPDLFNWLMNHGEPKDTELQRMVALIQTRN
KARGPVAM

Nucleotide

• Length: 267 bp

>AT238152 NZ_LR890236:23565-24008 [Klebsiella pneumoniae]
ATGAAAACATTTAGTTTGTCCTCAACTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
CGTAGCGCTTCTGGGCCAAATCAATGAAGGCTTGGACGGGAAGGTGGCGAACCGGATCACTGACTGGGCCAGAATAACCC
AGAATGACCTGAGAAAAATGTCCGGTATCCCGTCGACCACGTTTAGCCGCAGTGTGAAGGCACGTTTTAACCCGGAACAA
AGTGAACGTCTGGTTCGGATTATCCGCGTCATTGATCGGGCGGTAGATTTGTTTGAAGGTGACAAGGAAGCCGCACAGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATGGCATCCGAGACAGGAGCGTATGAGG
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA