Detailed information of TA system TA238151

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 2142168..2142985
• Replicon: chromosome
• Accession: NZ_CP093328
• Organism: Rahnella aceris strain S2-A69

Toxin (Protein)

• Gene name: -
• Uniprot ID: H8NRM1
• Locus tag: MNO10_RS09850
• Protein ID: WP_013574722.1
• Coordinates: 2142527..2142985 (+)
• Length: 153 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: MNO10_RS09845
• Protein ID: WP_231576083.1
• Coordinates: 2142168..2142530 (+)
• Length: 121 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MNO10_RS09825 (MNO10_09825)	2138094..2138855	+	762	WP_013574726.1	molybdopterin-synthase adenylyltransferase MoeB	-
MNO10_RS09830 (MNO10_09830)	2139049..2140644	-	1596	WP_013574725.1	ABC-F family ATPase	-
MNO10_RS09835 (MNO10_09835)	2140831..2141718	-	888	WP_013574724.1	nucleoside-specific channel-forming protein Tsx	-
MNO10_RS09840 (MNO10_09840)	2142026..2142181	-	156	WP_238321212.1	hypothetical protein	-
MNO10_RS09845 (MNO10_09845)	2142168..2142530	+	363	WP_231576083.1	DUF2384 domain-containing protein	Antitoxin
MNO10_RS09850 (MNO10_09850)	2142527..2142985	+	459	WP_013574722.1	RES family NAD+ phosphorylase	Toxin
MNO10_RS09855 (MNO10_09855)	2143013..2143465	-	453	WP_013574721.1	DMT family transporter	-
MNO10_RS09860 (MNO10_09860)	2143469..2143903	-	435	WP_013574720.1	DMT family transporter	-
MNO10_RS09865 (MNO10_09865)	2144006..2144938	+	933	WP_119261419.1	LysR family transcriptional regulator	-
MNO10_RS09870 (MNO10_09870)	2145126..2145584	-	459	WP_119261418.1	GNAT family N-acetyltransferase	-
MNO10_RS09875 (MNO10_09875)	2145675..2147360	-	1686	WP_013574717.1	choline dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (2-136)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (66-117)

Sequences

Toxin

Protein

• Length: 153 a.a.
• Molecular weight: 16974.55 Da
• Isoelectric Point: 4.7091

>T238151 WP_013574722.1 NZ_CP093328:2142527-2142985 [Rahnella aceris]
MKLFRIVQTRHLATAWSGAGAQLYGGRWNPPGRPVVYVTTSISLAILEILVHLQNSMLMRSYTLLSIEVPEELLDTLEVS
ELAADWRSASVPDSTQRQGDVWLAEGEYVGLKVPSVIVPSEYNVLLNPLHPAFADLLSSVEREPMMFDPRLQ

Nucleotide

• Length: 459 bp

>T238151 NZ_LR890235:c5159805-5159422 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin

Protein

• Length: 121 a.a.
• Molecular weight: 13276.25 Da
• Isoelectric Point: 7.0189

>AT238151 WP_231576083.1 NZ_CP093328:2142168-2142530 [Rahnella aceris]
MINAIQKGFPVDSISRLNTELGWPKMVLLEIMGINERNYARRKAGNGLLKSEESERVARLVRIVDAATDLFEGDRVSALE
WFTRPAPALDGSRPLELLSSEAGAVEVSRLIGRLQHGVFS

Nucleotide

• Length: 363 bp

>AT238151 NZ_LR890235:c5160047-5159805 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTTCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Structures

Toxin

• AlphaFold DB: H8NRM1