Detailed information of TA system TA238137

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 5343242..5343715
• Replicon: chromosome
• Accession: NZ_CP093323
• Organism: Serratia plymuthica strain B37/06

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: MNO11_RS25000
• Protein ID: WP_063202450.1
• Coordinates: 5343242..5343517 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A2X4TR66
• Locus tag: MNO11_RS25005
• Protein ID: WP_062869225.1
• Coordinates: 5343518..5343715 (-)
• Length: 66 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MNO11_RS24985 (MNO11_24985)	5338286..5338663	-	378	WP_241921432.1	AprI/Inh family metalloprotease inhibitor	-
MNO11_RS24990 (MNO11_24990)	5338719..5340182	-	1464	WP_241921433.1	serralysin family metalloprotease	-
MNO11_RS24995 (MNO11_24995)	5340866..5343181	+	2316	WP_241921434.1	zinc/cadmium/mercury/lead-transporting ATPase	-
MNO11_RS25000 (MNO11_25000)	5343242..5343517	-	276	WP_063202450.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
MNO11_RS25005 (MNO11_25005)	5343518..5343715	-	198	WP_062869225.1	hypothetical protein	Antitoxin
MNO11_RS25010 (MNO11_25010)	5343776..5344021	-	246	WP_004950955.1	sulfurtransferase TusA	-
MNO11_RS25015 (MNO11_25015)	5344242..5344907	+	666	WP_006323048.1	7-cyano-7-deazaguanine/7-aminomethyl-7- deazaguanine transporter	-
MNO11_RS25020 (MNO11_25020)	5344950..5345384	+	435	WP_241921435.1	GNAT family N-acetyltransferase	-
MNO11_RS25025 (MNO11_25025)	5345465..5346028	+	564	WP_004950949.1	DcrB family lipoprotein	-
MNO11_RS25030 (MNO11_25030)	5346077..5347276	-	1200	WP_241921436.1	anaerobic glycerol-3-phosphate dehydrogenase subunit GlpC	-
MNO11_RS25035 (MNO11_25035)	5347273..5348544	-	1272	WP_241922301.1	glycerol-3-phosphate dehydrogenase subunit GlpB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10660.56 Da
• Isoelectric Point: 11.2606

>T238137 WP_063202450.1 NZ_CP093323:c5343517-5343242 [Serratia plymuthica]
MLVIEWSRSARQDLADILLFIANDNPRAARKMKVLISEAILPAAEHPHIFRRGRVDGTHEIIVHPNYLLIYQVVADRIRV
MRVLHARRRYP

Nucleotide

• Length: 276 bp

>T238137 NZ_LR890230:c4672106-4671822 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Protein

• Length: 66 a.a.
• Molecular weight: 7580.65 Da
• Isoelectric Point: 4.4488

>AT238137 WP_062869225.1 NZ_CP093323:c5343715-5343518 [Serratia plymuthica]
MVILRSPVVSEYETQEQTEIYDRWFREKVREAMDDPLPGISHDEVMAEMDALIAVAEARKKTKQV

Nucleotide

• Length: 198 bp

>AT238137 NZ_LR890230:c4672338-4672096 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Structures

Antitoxin

• AlphaFold DB: A0A2X4TR66