Detailed information of TA system TA238136

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 5045525..5047148
• Replicon: chromosome
• Accession: NZ_CP093323
• Organism: Serratia plymuthica strain B37/06

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: MNO11_RS23520
• Protein ID: WP_241921360.1
• Coordinates: 5045525..5046847 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: MNO11_RS23525
• Protein ID: WP_241921361.1
• Coordinates: 5046852..5047148 (-)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MNO11_RS23500 (MNO11_23500)	5040674..5041147	+	474	WP_241921356.1	DNA mismatch endonuclease Vsr	-
MNO11_RS23505 (MNO11_23505)	5041307..5042533	+	1227	WP_241921357.1	type II restriction endonuclease	-
MNO11_RS23510 (MNO11_23510)	5042552..5043637	+	1086	WP_241921358.1	hypothetical protein	-
MNO11_RS23515 (MNO11_23515)	5043709..5045283	+	1575	WP_241921359.1	DUF262 domain-containing protein	-
MNO11_RS23520 (MNO11_23520)	5045525..5046847	-	1323	WP_241921360.1	type II toxin-antitoxin system HipA family toxin	Toxin
MNO11_RS23525 (MNO11_23525)	5046852..5047148	-	297	WP_241921361.1	helix-turn-helix transcriptional regulator	Antitoxin
MNO11_RS23530 (MNO11_23530)	5047447..5047827	-	381	WP_241921362.1	hypothetical protein	-
MNO11_RS23535 (MNO11_23535)	5048009..5048389	-	381	WP_241921363.1	hypothetical protein	-
MNO11_RS23540 (MNO11_23540)	5048386..5048907	-	522	WP_241921364.1	type IV secretion protein Rhs	-
MNO11_RS23545 (MNO11_23545)	5049326..5049568	-	243	WP_241921365.1	contact-dependent growth inhibition system immunity protein	-
MNO11_RS23550 (MNO11_23550)	5049565..5049702	-	138	WP_197931114.1	hypothetical protein	-
MNO11_RS23555 (MNO11_23555)	5050010..5050645	-	636	WP_241921366.1	carbonic anhydrase	-
MNO11_RS23560 (MNO11_23560)	5050776..5051024	-	249	WP_241921367.1	ribbon-helix-helix domain-containing protein	-
MNO11_RS23565 (MNO11_23565)	5051039..5051530	-	492	WP_241921368.1	hypothetical protein	-
MNO11_RS23570 (MNO11_23570)	5051771..5052034	+	264	WP_241921369.1	DUF1819 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	5019360..5056857	37497

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (154-403)

Antitoxin

• Cro/C1-type helix-turn-helix domain (20-70)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 50172.20 Da
• Isoelectric Point: 6.6335

>T238136 WP_241921360.1 NZ_CP093323:c5046847-5045525 [Serratia plymuthica]
MRRSQQRLAIWMNGIPVGYWEKRKGEDRLEYLPDWIADSQGRPLSLSLPFTPGNQPYRGSVVRDYFDNLLPDSEGIRRRL
AMRYRAESLDPFDLLAELGRDCVGAIQLLDIDEQPSHIFSIRQRPFSEAQIAERLRNAATMLPGRQGQDDDLRLSIAGAQ
EKTALLWHDDQWCLPEGNTPTTHIFKLALGLVGNMRADMSTSIENEWLCSLILEHYGVPVARTHIAQFEDQKALIVERFD
RKLSSDRQWWIRLPQEDMCQALGVSPLKKYQSDGGPGITDIMEILSRSDQAETDRRHFFKAQIIFWLLAATDGHAKNFSL
AHLPQNRYHLTPLYDVLSAWPLIGPGNSQIAWQKCKLAMAVRGSSNYYHISQIRRRHWIKHGEITGLGQQEVESIIEELL
AATPGVIERVAGLLPEQFPPELAACIFDGIRQQCSRLEGK

Nucleotide

• Length: 1323 bp

>T238136 NZ_LR890230:c4568429-4567896 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCAGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 11015.53 Da
• Isoelectric Point: 8.0100

>AT238136 WP_241921361.1 NZ_CP093323:c5047148-5046852 [Serratia plymuthica]
MNTVYPLKTLSQLRPLLVGFRKAKGLTQKDVSERLGVTQQTYARLESNPASASMERLFRVFNVLGIEVVFSSELTSPGCE
TEETATTHIDSPARREQW

Nucleotide

• Length: 297 bp

>AT238136 NZ_LR890230:c4568706-4568440 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA