Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 4639611..4640167 Replicon chromosome
Accession NZ_CP093323
Organism Serratia plymuthica strain B37/06

Toxin (Protein)


Gene name parE Uniprot ID A0A2X4UAE5
Locus tag MNO11_RS21610 Protein ID WP_063202630.1
Coordinates 4639877..4640167 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag MNO11_RS21605 Protein ID WP_166728990.1
Coordinates 4639611..4639889 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNO11_RS21580 (MNO11_21580) 4634952..4635791 - 840 WP_241921248.1 MurR/RpiR family transcriptional regulator -
MNO11_RS21585 (MNO11_21585) 4635936..4637522 + 1587 WP_241921249.1 gamma-glutamyltransferase -
MNO11_RS21590 (MNO11_21590) 4637547..4637738 + 192 WP_006322394.1 oxalurate catabolism protein HpxX -
MNO11_RS21595 (MNO11_21595) 4637735..4639135 + 1401 WP_197912129.1 AtzE family amidohydrolase -
MNO11_RS21600 (MNO11_21600) 4639139..4639525 + 387 WP_004949013.1 oxalurate catabolism protein HpxZ -
MNO11_RS21605 (MNO11_21605) 4639611..4639889 + 279 WP_166728990.1 CopG family ribbon-helix-helix protein Antitoxin
MNO11_RS21610 (MNO11_21610) 4639877..4640167 + 291 WP_063202630.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MNO11_RS21615 (MNO11_21615) 4640177..4641061 - 885 WP_063202632.1 siderophore-interacting protein -
MNO11_RS21620 (MNO11_21620) 4641067..4642290 - 1224 WP_241921250.1 MFS transporter -
MNO11_RS21625 (MNO11_21625) 4642428..4644173 + 1746 WP_241921251.1 IucA/IucC family protein -
MNO11_RS21630 (MNO11_21630) 4644170..4645120 + 951 WP_197928546.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-93)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10904.65 Da        Isoelectric Point: 9.5469

>T238135 WP_063202630.1 NZ_CP093323:4639877-4640167 [Serratia plymuthica]
VPQLIWTPAALLDVQQLYRFLAEKDLNSAKRAVATIRNCIKIIAHQPHIGRPAKDMAPEFREWPIDFGNSGYLVLYRFNG
VTAVILAIRHQSETGY

Download         Length: 291 bp

>T238135 NZ_LR890230:3968166-3968384 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10627.68 Da        Isoelectric Point: 4.9323

>AT238135 WP_166728990.1 NZ_CP093323:4639611-4639889 [Serratia plymuthica]
MATATSIKIDDELKQRVQHIAAAHQRSAHWIMREAIREYVEREEKREAVRNDALQAWETYQANGKHLTQDEADGWLSDLE
KGDDTEIPGCHN

Download         Length: 279 bp

>AT238135 NZ_LR890230:3967765-3968139 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAACTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2X4UAE5

Antitoxin

Source ID Structure

References