Detailed information of TA system TA238133

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 3903974..3904527
• Replicon: chromosome
• Accession: NZ_CP093323
• Organism: Serratia plymuthica strain B37/06

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: S4YH80
• Locus tag: MNO11_RS17970
• Protein ID: WP_020438747.1
• Coordinates: 3903974..3904288 (-)
• Length: 105 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: S4YG56
• Locus tag: MNO11_RS17975
• Protein ID: WP_020438746.1
• Coordinates: 3904291..3904527 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MNO11_RS17950 (MNO11_17950)	3899742..3900899	-	1158	WP_197927875.1	YbfB/YjiJ family MFS transporter	-
MNO11_RS17955 (MNO11_17955)	3901007..3901924	+	918	WP_063199956.1	LysR family transcriptional regulator	-
MNO11_RS17960 (MNO11_17960)	3901953..3903080	+	1128	WP_062870249.1	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase	-
MNO11_RS17965 (MNO11_17965)	3903095..3903937	+	843	WP_004942338.1	S-formylglutathione hydrolase	-
MNO11_RS17970 (MNO11_17970)	3903974..3904288	-	315	WP_020438747.1	CcdB family protein	Toxin
MNO11_RS17975 (MNO11_17975)	3904291..3904527	-	237	WP_020438746.1	type II toxin-antitoxin system CcdA family antitoxin	Antitoxin
MNO11_RS17980 (MNO11_17980)	3904672..3905580	-	909	WP_201087296.1	glutathione ABC transporter permease GsiD	-
MNO11_RS17985 (MNO11_17985)	3905590..3906510	-	921	WP_241921036.1	glutathione ABC transporter permease GsiC	-
MNO11_RS17990 (MNO11_17990)	3906563..3908101	-	1539	WP_004942332.1	glutathione ABC transporter substrate-binding protein GsiB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin CcdB (2-103)

Antitoxin

• Post-segregation antitoxin CcdA (9-78)

Sequences

Toxin

Protein

• Length: 105 a.a.
• Molecular weight: 11685.58 Da
• Isoelectric Point: 5.8036

>T238133 WP_020438747.1 NZ_CP093323:c3904288-3903974 [Serratia plymuthica]
MQFTVYANTGKSAVYPLLLDVTSDIIGQLNRRVVIPLLPIEKYPASTRPERLNPLVRLVDDNEYAVMTHEMASIPVRILG
AEFCDASQYRTKVKAAIDFLFDGI

Nucleotide

• Length: 315 bp

>T238133 NZ_LR890230:2369863-2370180 [Klebsiella pneumoniae]
ATGTTGACTTTTATTGAACTACAAGGTTTCAGTAAGCGACGCCAGGTGCTGTTGCAGGATGATGAATTTCGGGCCTTTCA
GGAAATCCTTATAAACGATCCCGAGGCTGGGGACACAATTTCGGGAACCGGTGGTTTTCGTAAAATTCGCTGGAGTCGTC
CCGGGATGGGGAAGCGCGGCGGTGTACGAGTGATTTACTATAATGTAACGAAAAAGGGAAGAATTTACCTGGCGCTCATC
TATCCTAAAAATGAACAGGATGAGTTAAATCAGGAGCAAAAAAAGATGTTGAGACAAGTGGCTGATTTAATAAACTAG

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 9078.16 Da
• Isoelectric Point: 6.7184

>AT238133 WP_020438746.1 NZ_CP093323:c3904527-3904291 [Serratia plymuthica]
MPVKQRTTQSVTMAVERSLLSRAREAGINLSATLNAALDAELRQHEMRKWKEENREAIDALNRFHDEHGCFSDEYRTF

Nucleotide

• Length: 237 bp

>AT238133 NZ_LR890230:2370256-2370552 [Klebsiella pneumoniae]
ATGAAAGACGAATTGTTTGCCGATCTGCTGGCGAGTGCAGAAGAAATGGTCAGGATCGAGAAAGGTGAACAAATGCCGAT
GGAGCAGCACGTTCATACCTTCAGCGAAATTGACGTGAAAGCGATACGTGAAGCCACAGGTTTAAAACAGCAGGACTTTG
CAGCGGCCGTTGGCGTTAGCTACGAGTTGGTTAAAAGCTGGGAAACGAAACGACGTCAGCCAACCGGTGCAGCCAGAAAA
CTGCTTTTATTGCTTCAGGGTAATCCATTGATTATCAACTTGTTGAAGGTTGTTTGA

Structures

Toxin

• AlphaFold DB: S4YH80

Antitoxin

• AlphaFold DB: S4YG56