238124

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2311287..2311912 Replicon chromosome
Accession NZ_CP093323
Organism Serratia plymuthica strain B37/06

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag MNO11_RS10515 Protein ID WP_063201925.1
Coordinates 2311730..2311912 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag MNO11_RS10510 Protein ID WP_063201920.1
Coordinates 2311287..2311700 (-) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNO11_RS10480 (MNO11_10480) 2306515..2307237 + 723 WP_004945948.1 RNA polymerase sigma factor FliA -
MNO11_RS10485 (MNO11_10485) 2307294..2307803 + 510 WP_063201911.1 flagella biosynthesis regulatory protein FliZ -
MNO11_RS10490 (MNO11_10490) 2307929..2308921 + 993 WP_063201914.1 D-cysteine desulfhydrase -
MNO11_RS10495 (MNO11_10495) 2309036..2309836 + 801 WP_197930767.1 cystine ABC transporter substrate-binding protein -
MNO11_RS10500 (MNO11_10500) 2309836..2310498 + 663 WP_006321381.1 cystine ABC transporter permease -
MNO11_RS10505 (MNO11_10505) 2310502..2311254 + 753 WP_062871168.1 L-cystine ABC transporter ATP-binding protein TcyN -
MNO11_RS10510 (MNO11_10510) 2311287..2311700 - 414 WP_063201920.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
MNO11_RS10515 (MNO11_10515) 2311730..2311912 - 183 WP_063201925.1 type II toxin-antitoxin system HicA family toxin Toxin
MNO11_RS10520 (MNO11_10520) 2312079..2316050 - 3972 WP_241922120.1 trifunctional transcriptional regulator/proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6893.14 Da        Isoelectric Point: 11.0382

>T238124 WP_063201925.1 NZ_CP093323:c2311912-2311730 [Serratia plymuthica]
VKSSELIRLLEREGWVLERIKGSHHQFKHPGSRLVITVPHPRKDLKPGTLRQIMKDAGLC

Download         Length: 183 bp

>T238124 NZ_LR890217:c4659660-4659376 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCTGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15092.85 Da        Isoelectric Point: 4.6961

>AT238124 WP_063201920.1 NZ_CP093323:c2311700-2311287 [Serratia plymuthica]
MFYPAYVHSDLDGSASGFFPDVPGCYFAGDTLDKAFEDAKGALDAHFELLSEDNQAIPRPQAVSFHLAQENDTLNGGQWL
LVDINMDKFDGRAERINITLPHRLLNRIDSLVQQHPGYGSRSAFLAAAARNELLKVG

Download         Length: 414 bp

>AT238124 NZ_LR890217:c4659892-4659650 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGTCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References