Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1502846..1503313 Replicon chromosome
Accession NZ_CP093323
Organism Serratia plymuthica strain B37/06

Toxin (Protein)


Gene name relE Uniprot ID A0A1B1KUP0
Locus tag MNO11_RS06750 Protein ID WP_006316908.1
Coordinates 1503044..1503313 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7U3Z4H1
Locus tag MNO11_RS06745 Protein ID WP_013814083.1
Coordinates 1502846..1503040 (+) Length 65 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNO11_RS06720 (MNO11_06720) 1498069..1498548 + 480 Protein_1313 DUF637 domain-containing protein -
MNO11_RS06725 (MNO11_06725) 1498997..1499809 + 813 WP_241921846.1 hypothetical protein -
MNO11_RS06730 (MNO11_06730) 1499884..1500375 - 492 WP_241921847.1 TIR domain-containing protein -
MNO11_RS06735 (MNO11_06735) 1500372..1501826 - 1455 WP_241921848.1 SIR2 family protein -
MNO11_RS06740 (MNO11_06740) 1502148..1502699 - 552 WP_004951898.1 spermidine N1-acetyltransferase -
MNO11_RS06745 (MNO11_06745) 1502846..1503040 + 195 WP_013814083.1 hypothetical protein Antitoxin
MNO11_RS06750 (MNO11_06750) 1503044..1503313 + 270 WP_006316908.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MNO11_RS06755 (MNO11_06755) 1503367..1504005 - 639 WP_037433480.1 phosphoribosylglycinamide formyltransferase -
MNO11_RS06760 (MNO11_06760) 1504005..1505042 - 1038 WP_006316901.1 phosphoribosylformylglycinamidine cyclo-ligase -
MNO11_RS06765 (MNO11_06765) 1505298..1505924 + 627 WP_006327216.1 uracil phosphoribosyltransferase -
MNO11_RS06770 (MNO11_06770) 1506125..1507414 + 1290 WP_063197301.1 uracil permease -
MNO11_RS06775 (MNO11_06775) 1507464..1507712 - 249 WP_004951888.1 GlsB/YeaQ/YmgE family stress response membrane protein -
MNO11_RS06780 (MNO11_06780) 1507751..1508266 - 516 WP_006327215.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-88)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10611.19 Da        Isoelectric Point: 6.0726

>T238123 WP_006316908.1 NZ_CP093323:1503044-1503313 [Serratia plymuthica]
MRIEWSREAQEELWNIIDYIDDRNPQAALILQREIETAVHSLSLNPFMYRLGRVDNTREIVVHPNYLIVYRIIGHIEVLG
VIHAKREYP

Download         Length: 270 bp

>T238123 NZ_LR890217:c4572704-4572363 [Klebsiella pneumoniae]
ATGAAAACTCTACCTGCAACAAATCCGCAGGCGGCGACGCTATATCTGTCGCCTGTGGCAGTCTGGCAAATGCTGCTTGC
ACGCCTGCTGGAACAACATTATGGCCTGACTCTCAACGACACACCATTCAGTGATGAAACGGTAATTCAGGAACATATCG
ATGCCGGTATATCTTTGGCCGATGCCGTTAATTTTCTGGTGGAAAAGTACGGGCTGGTTCGTATTGATCGCAGGGGATTC
GACTGGCAAGAACAGTCCCCATATCTGCGGGCAGTCGATATTATGCGGGCGCGACAGGCAACTGGTTTATTGAAAAGAAA
TCGTATTAGCGCGGCACGGTGA

Antitoxin


Download         Length: 65 a.a.        Molecular weight: 7443.65 Da        Isoelectric Point: 10.2045

>AT238123 WP_013814083.1 NZ_CP093323:1502846-1503040 [Serratia plymuthica]
MVIKTSLSTQPTAEVAEQGESYDRWFRAKIEAAINSEKPRIPHEQVMNEMQIRLAAKKKIRKME

Download         Length: 195 bp

>AT238123 NZ_LR890217:c4573066-4572725 [Klebsiella pneumoniae]
ATGAAATCTACTGACTCAGAGAACGATTCATTTTTAAAATGGGGACTGAATTGTAATATGACACCTTGCTTTGGTGCTCG
TCTGGTACAGGAGGGAAACCGGCTGCACTATCTGGCTGATCGGGCCTGCATTACCGGTGAATTCAGTAACGCAGAATCTT
TGAAGTTGGATGAAGTATTCACACGTTTTATCCGCCAAATGGAATCGATGCTGACCACTGGTGAAATGAATCCTCGCCAT
GCCCACAGTGTCACCCTGTACCACAACGGTTTCACCTGCGAAGCCGATACCCTTGGCAGTTGCGGCTACGTATACATCGC
CGTTTACCCCACTCATCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B1KUP0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U3Z4H1

References