Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1457148..1457803 Replicon chromosome
Accession NZ_CP093323
Organism Serratia plymuthica strain B37/06

Toxin (Protein)


Gene name vapC Uniprot ID A0A1B1KUT7
Locus tag MNO11_RS06595 Protein ID WP_006318241.1
Coordinates 1457414..1457803 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1B1KUW5
Locus tag MNO11_RS06590 Protein ID WP_006318240.1
Coordinates 1457148..1457411 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNO11_RS06575 (MNO11_06575) 1453485..1454384 - 900 WP_006327236.1 lipid kinase YegS -
MNO11_RS06580 (MNO11_06580) 1454872..1456224 - 1353 WP_241921833.1 tRNA 5-hydroxyuridine modification protein YegQ -
MNO11_RS06585 (MNO11_06585) 1456460..1456798 - 339 WP_004951963.1 YegP family protein -
MNO11_RS06590 (MNO11_06590) 1457148..1457411 + 264 WP_006318240.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
MNO11_RS06595 (MNO11_06595) 1457414..1457803 + 390 WP_006318241.1 type II toxin-antitoxin system VapC family toxin Toxin
MNO11_RS06600 (MNO11_06600) 1457798..1458514 - 717 WP_004951961.1 two-component system response regulator BaeR -
MNO11_RS06605 (MNO11_06605) 1458514..1459896 - 1383 WP_062868259.1 two-component system sensor histidine kinase BaeS -
MNO11_RS06610 (MNO11_06610) 1459893..1461326 - 1434 WP_241921834.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14048.36 Da        Isoelectric Point: 7.8817

>T238122 WP_006318241.1 NZ_CP093323:1457414-1457803 [Serratia plymuthica]
MYMFDTNTVSHLFRRHPGLLSAMEKVPPSTVCISSITEAELLFGVAKRQSKALKAMVTAFLAAVTVYDWDSEAARCYGVM
RASMEKKGKVLGALDQLIAAHALSRGATMVTSDRAFGMVSGLDVEDWTL

Download         Length: 390 bp

>T238122 NZ_LR890217:c4533186-4532653 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGACAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10140.43 Da        Isoelectric Point: 4.8950

>AT238122 WP_006318240.1 NZ_CP093323:1457148-1457411 [Serratia plymuthica]
MERIAKLFKNGRNQAVRLPVEFEFDTDRVYIRRDREGNVILSKYPAKPDSWEPLLNIIAKTPVPHDFLGADERQQGIADR
DPFAEEE

Download         Length: 264 bp

>AT238122 NZ_LR890217:c4533463-4533197 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B1KUT7

Antitoxin

Source ID Structure
AlphaFold DB A0A1B1KUW5

References