Detailed information of TA system TA238120

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 1046671..1047340
• Replicon: chromosome
• Accession: NZ_CP093323
• Organism: Serratia plymuthica strain B37/06

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: S4YKD8
• Locus tag: MNO11_RS04675
• Protein ID: WP_006327725.1
• Coordinates: 1046918..1047340 (+)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: S4YS10
• Locus tag: MNO11_RS04670
• Protein ID: WP_004952428.1
• Coordinates: 1046671..1046937 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MNO11_RS04645 (MNO11_04645)	1041795..1043120	+	1326	WP_241921734.1	MFS transporter	-
MNO11_RS04650 (MNO11_04650)	1043170..1043778	-	609	WP_241921735.1	HD domain-containing protein	-
MNO11_RS04655 (MNO11_04655)	1043969..1044646	+	678	WP_062868500.1	hemolysin III family protein	-
MNO11_RS04660 (MNO11_04660)	1044809..1045306	+	498	WP_063200127.1	DUF2165 domain-containing protein	-
MNO11_RS04665 (MNO11_04665)	1045360..1046346	-	987	WP_006327726.1	tRNA-modifying protein YgfZ	-
MNO11_RS04670 (MNO11_04670)	1046671..1046937	+	267	WP_004952428.1	FAD assembly factor SdhE	Antitoxin
MNO11_RS04675 (MNO11_04675)	1046918..1047340	+	423	WP_006327725.1	protein YgfX	Toxin
MNO11_RS04680 (MNO11_04680)	1047340..1048035	+	696	WP_062868495.1	two-component system response regulator CreB	-
MNO11_RS04685 (MNO11_04685)	1048032..1049450	+	1419	WP_241921736.1	two-component system sensor histidine kinase CreC	-
MNO11_RS04690 (MNO11_04690)	1049535..1050899	+	1365	WP_063200135.1	cell envelope integrity protein CreD	-
MNO11_RS04695 (MNO11_04695)	1050937..1051455	-	519	WP_004952413.1	flavodoxin FldB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 16461.41 Da
• Isoelectric Point: 11.0260

>T238120 WP_006327725.1 NZ_CP093323:1046918-1047340 [Serratia plymuthica]
VAQWRCNVRISWRTQLLSLLTHGVLILLILISPWPEGYGPIWLVLLTLVVFECIRSQKRIASRQGELRLLANKRLSWHGQ
EWLLAKQPWMPRYGILLTLQPTQGKKRRRLWLASDSMGKAEWRHLRQLLLHPSADDDEEP

Nucleotide

• Length: 423 bp

>T238120 NZ_LR890217:c3800306-3799989 [Klebsiella pneumoniae]
ATGTTCAGATTGGTTGTGCATGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGCCCATTGTCCAGGCGAAGATGATCCG
GCAATTAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGACAGTAAACCGCTGGGGCAGGGGCTATTTGAAA
TTCGTGCGTTAGGTTCGGTACAGGGGCGAGGGATCTACGTTTTTCAGCAAGGCAAGACGCTCTTGCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACCCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10446.90 Da
• Isoelectric Point: 5.0843

>AT238120 WP_004952428.1 NZ_CP093323:1046671-1046937 [Serratia plymuthica]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDQLNDTDKALFIRLLESDDPDLFNWLMNHGAPQDSELQRMVTLIQTRN
KDRGPVAM

Nucleotide

• Length: 267 bp

>AT238120 NZ_LR890217:c3799996-3799709 [Klebsiella pneumoniae]
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACAGAACTGCTTGGCCAGCCTGAGGTTCAGGCTGCATTCGATGC
GCAAGAACGTCAACAGCGATTACGTACTATGCTGGCGCAATGGCGCGAGCAGGCGGGGCTAACCCGAGCCCAGGTGGCGC
AGAGGATGGGGGTGAGTGCGCCGACGGTCTCCAGAATGGAAGCCAATATCACCCGCGCCAGTCTGGATACCTTAACGCGA
TACGCGTTAGCCTGCGGTATAAAGCACCCGCAAGTTTTACTTTACTAA

Structures

Toxin

• AlphaFold DB: S4YKD8

Antitoxin

• AlphaFold DB: S4YS10