Detailed information of TA system TA238119

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-parD/-
• Location: 369083..369647
• Replicon: chromosome
• Accession: NZ_CP093323
• Organism: Serratia plymuthica strain B37/06

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: MNO11_RS01630
• Protein ID: WP_241921586.1
• Coordinates: 369083..369322 (-)
• Length: 80 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A2X4VH61
• Locus tag: MNO11_RS01635
• Protein ID: WP_062868918.1
• Coordinates: 369378..369647 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MNO11_RS01610 (MNO11_01610)	365248..365586	-	339	WP_041416656.1	PTS lactose/cellobiose transporter subunit IIA	-
MNO11_RS01615 (MNO11_01615)	365943..366512	+	570	WP_062868920.1	peptidylprolyl isomerase A	-
MNO11_RS01620 (MNO11_01620)	366672..368357	+	1686	WP_037433755.1	sensor histidine kinase	-
MNO11_RS01625 (MNO11_01625)	368357..369082	+	726	WP_063200586.1	two-component system response regulator BtsR	-
MNO11_RS01630 (MNO11_01630)	369083..369322	-	240	WP_241921586.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MNO11_RS01635 (MNO11_01635)	369378..369647	-	270	WP_062868918.1	hypothetical protein	Antitoxin
MNO11_RS01640 (MNO11_01640)	369877..371403	+	1527	WP_241921587.1	DUF853 family protein	-
MNO11_RS01645 (MNO11_01645)	371509..372084	+	576	WP_006328493.1	aminodeoxychorismate synthase component II	-
MNO11_RS01650 (MNO11_01650)	372216..373433	+	1218	WP_062868917.1	aspartate aminotransferase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-76)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 80 a.a.
• Molecular weight: 8730.08 Da
• Isoelectric Point: 7.3990

>T238119 WP_241921586.1 NZ_CP093323:c369322-369083 [Serratia plymuthica]
MAIYDYLETKNPAAAIEIDSLISAAATRLSQNPSSGKPGRVPGTHEMVIHHSYFLVYELINGLIIMLAVVHARRQWPAN

Nucleotide

• Length: 240 bp

>T238119 NZ_LR890217:c2659864-2658542 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
CAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCTGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10352.65 Da
• Isoelectric Point: 7.0169

>AT238119 WP_062868918.1 NZ_CP093323:c369647-369378 [Serratia plymuthica]
MSESTVVIRVDEELKIAFASAAKAADRTASQLLRDFMRDFVSRQTHQKEYEQWLQEKVDLSRKALNEGKITDNEAVEAYF
AERRSKLTR

Nucleotide

• Length: 270 bp

>AT238119 NZ_LR890217:c2660130-2659864 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A2X4VH61