Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeV-yfjZ/CbtA-CbeA
Location 4310759..4311465 Replicon chromosome
Accession NZ_CP093322
Organism Yersinia intermedia strain N6/293

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag MNQ97_RS19610 Protein ID WP_241915900.1
Coordinates 4311130..4311465 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag MNQ97_RS19605 Protein ID WP_241915899.1
Coordinates 4310759..4311091 (-) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNQ97_RS19585 (MNQ97_19585) 4305961..4306317 + 357 WP_241915895.1 hypothetical protein -
MNQ97_RS19590 (MNQ97_19590) 4306461..4307915 - 1455 WP_241915896.1 hypothetical protein -
MNQ97_RS19595 (MNQ97_19595) 4308387..4309472 + 1086 WP_241915897.1 endonuclease NucS -
MNQ97_RS19600 (MNQ97_19600) 4309814..4310674 - 861 WP_241915898.1 DUF4942 domain-containing protein -
MNQ97_RS19605 (MNQ97_19605) 4310759..4311091 - 333 WP_241915899.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
MNQ97_RS19610 (MNQ97_19610) 4311130..4311465 - 336 WP_241915900.1 TA system toxin CbtA family protein Toxin
MNQ97_RS19615 (MNQ97_19615) 4311547..4311627 - 81 WP_241916467.1 hypothetical protein -
MNQ97_RS19620 (MNQ97_19620) 4311627..4312112 - 486 WP_241915901.1 DNA repair protein RadC -
MNQ97_RS19625 (MNQ97_19625) 4312132..4312563 - 432 WP_241915902.1 antirestriction protein -
MNQ97_RS19630 (MNQ97_19630) 4312924..4313745 - 822 WP_241915903.1 DUF932 domain-containing protein -
MNQ97_RS19635 (MNQ97_19635) 4313894..4314385 - 492 WP_241915904.1 hypothetical protein -
MNQ97_RS19640 (MNQ97_19640) 4314388..4314942 - 555 WP_241915905.1 hypothetical protein -
MNQ97_RS19645 (MNQ97_19645) 4315252..4316157 - 906 WP_241915906.1 50S ribosome-binding GTPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4296654..4319208 22554


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(9-101)

Antitoxin

Antitoxin CbeA

(9-108)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12118.84 Da        Isoelectric Point: 7.4644

>T238118 WP_241915900.1 NZ_CP093322:c4311465-4311130 [Yersinia intermedia]
MKPHPTAAGALPVSAIYQQLLAFLLEHHYGLSLNDTPYHDEQVIAQQIEQGISVGDTVNTLVEKYALVRIGRTGFSALAQ
NPTLSKGDIARARQAAGLWRAHFPPTLLYPT

Download         Length: 336 bp

>T238118 NZ_LR890217:1905727-1905829 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12045.67 Da        Isoelectric Point: 7.4212

>AT238118 WP_241915899.1 NZ_CP093322:c4311091-4310759 [Yersinia intermedia]
MNNNTSTSPAWGLKRDITPRLGARLVQEGTHLHFLSDRAHIVGTFSLEATQALDAAFPALITKLESQLLSGALDPRRQQG
ITVRHGEFVCEADTLGSHGYLYIAVYQKLA

Download         Length: 333 bp

>AT238118 NZ_LR890217:c1905836-1905691 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References