Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /COG5642-COG5654
Location 2411493..2412483 Replicon chromosome
Accession NZ_CP093322
Organism Yersinia intermedia strain N6/293

Toxin (Protein)


Gene name - Uniprot ID A0A209A434
Locus tag MNQ97_RS11035 Protein ID WP_050085270.1
Coordinates 2411493..2411951 (-) Length 153 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0T9M4Z0
Locus tag MNQ97_RS11040 Protein ID WP_005184401.1
Coordinates 2412037..2412483 (-) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNQ97_RS11005 (MNQ97_11005) 2407275..2407940 + 666 WP_005184417.1 phage shock protein PspA -
MNQ97_RS11010 (MNQ97_11010) 2408082..2408309 + 228 WP_032906081.1 envelope stress response membrane protein PspB -
MNQ97_RS11015 (MNQ97_11015) 2408309..2408683 + 375 WP_050085264.1 envelope stress response membrane protein PspC -
MNQ97_RS11020 (MNQ97_11020) 2408792..2409031 + 240 WP_050085265.1 phage shock protein PspD -
MNQ97_RS11025 (MNQ97_11025) 2409012..2410409 + 1398 WP_032906079.1 YcjX family protein -
MNQ97_RS11030 (MNQ97_11030) 2410406..2411467 + 1062 WP_241916419.1 YcjF family protein -
MNQ97_RS11035 (MNQ97_11035) 2411493..2411951 - 459 WP_050085270.1 RES family NAD+ phosphorylase Toxin
MNQ97_RS11040 (MNQ97_11040) 2412037..2412483 - 447 WP_005184401.1 DUF2384 domain-containing protein Antitoxin
MNQ97_RS11045 (MNQ97_11045) 2412801..2414378 + 1578 WP_042569805.1 transcriptional regulator TyrR -
MNQ97_RS11050 (MNQ97_11050) 2414491..2414994 - 504 WP_050085272.1 thiol peroxidase -
MNQ97_RS11055 (MNQ97_11055) 2415148..2416119 + 972 WP_087815719.1 L-Ala-D/L-Glu epimerase -
MNQ97_RS11060 (MNQ97_11060) 2416116..2416823 - 708 WP_050312149.1 murein tripeptide amidase MpaA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-146)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(94-145)


Sequences

Toxin        


Download         Length: 153 a.a.        Molecular weight: 17219.67 Da        Isoelectric Point: 4.8938

>T238116 WP_050085270.1 NZ_CP093322:c2411951-2411493 [Yersinia intermedia]
MMFYRIVMRRYLASTWTGYGAEIYGGRWNHKGHAAIYLASSVSLAMLETLVHIQDSSTLSEFELFQIEIDDSNIMLLQPQ
DWPLDWRNDPAPAATMDIGTEWLESESSIGLLVPSTLVPSEHNMLVNPRHKDFQACLSTAKALAFAFDPRLK

Download         Length: 459 bp

>T238116 NZ_LR890217:351315-351662 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCTTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTCCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16256.70 Da        Isoelectric Point: 9.1234

>AT238116 WP_005184401.1 NZ_CP093322:c2412483-2412037 [Yersinia intermedia]
MRAYQPTPTTKAGALWREIGLPASRGTVLVDSIKLGFSVDVIDSIHLWASMPKSEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAIVWMSTPIKGLGHRSPDSLLETETGALEICDLIGRLEHGVFS

Download         Length: 447 bp

>AT238116 NZ_LR890217:351662-351961 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGAAAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGACTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A209A434

Antitoxin

Source ID Structure
AlphaFold DB A0A0T9M4Z0

References