Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeV-yfjZ/CbtA-CbeA
Location 1569816..1570537 Replicon chromosome
Accession NZ_CP093322
Organism Yersinia intermedia strain N6/293

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag MNQ97_RS07140 Protein ID WP_241916230.1
Coordinates 1570202..1570537 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag MNQ97_RS07135 Protein ID WP_241916229.1
Coordinates 1569816..1570163 (-) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNQ97_RS07115 (MNQ97_07115) 1565011..1566165 - 1155 WP_050085090.1 MFS transporter -
MNQ97_RS07120 (MNQ97_07120) 1567187..1568293 + 1107 WP_050132692.1 porin OmpC -
MNQ97_RS07130 (MNQ97_07130) 1568888..1569748 - 861 Protein_1391 DUF4942 domain-containing protein -
MNQ97_RS07135 (MNQ97_07135) 1569816..1570163 - 348 WP_241916229.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
MNQ97_RS07140 (MNQ97_07140) 1570202..1570537 - 336 WP_241916230.1 TA system toxin CbtA family protein Toxin
MNQ97_RS07145 (MNQ97_07145) 1570594..1570920 - 327 WP_241916231.1 DUF5983 family protein -
MNQ97_RS07150 (MNQ97_07150) 1571074..1571724 - 651 WP_241916232.1 hypothetical protein -
MNQ97_RS07155 (MNQ97_07155) 1571748..1572236 - 489 WP_241916233.1 DNA repair protein RadC -
MNQ97_RS07160 (MNQ97_07160) 1572257..1572688 - 432 WP_241916234.1 antirestriction protein -
MNQ97_RS07165 (MNQ97_07165) 1573049..1573870 - 822 WP_241916235.1 DUF932 domain-containing protein -
MNQ97_RS07170 (MNQ97_07170) 1573945..1574391 - 447 WP_241916236.1 hypothetical protein -
MNQ97_RS07175 (MNQ97_07175) 1574414..1574596 - 183 WP_241916237.1 hypothetical protein -
MNQ97_RS07180 (MNQ97_07180) 1574612..1575163 - 552 WP_241916238.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1569221..1590003 20782


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(5-101)

Antitoxin

Antitoxin CbeA

(9-108)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12194.01 Da        Isoelectric Point: 8.4876

>T238107 WP_241916230.1 NZ_CP093322:c1570537-1570202 [Yersinia intermedia]
MKPRATPPGTLPVSAIYQQLLAFLLKHHYGLSLNDTPYHDEQVIAQQIEQGISVGDTVNALVEQYALVRIGRTGFSALAQ
DPMLSKGDIARARQAAGLWRAHFPPTLLYPT

Download         Length: 336 bp

>T238107 NZ_LR890209:c4874174-4873257 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCCTATTATCGGCAGGTTGCTCTGTTAATGCAGGTTTTACCCTATGTTGCCGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACGGCAATCAATCTCTTTATCCGTGATTTCCCACGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAACGATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCTAATCTGCAACAACAG
GCAGGTATGAACGCTGTATTACAAGCTAATCGTTCCGATGAGATGCGTGTCGTTGTTACTACCGATAGCGCACAAATAAA
GATAGAGGTCTCACCGGTCGCACGGGGAACATTATATCCACCACAGGAGCGAGAGGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCGGTGGTTTCGTTGCCCGATCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGATGTGAAATTACTTCTTGATGCGCAGGAGCTTAACCGTCCCATTTTCAATGGGTTTATCGCGTA
TTTACTTAGCCATAATCGGCCTCTGGCTGAAGTGCTTAGTCCTCGCTGGAAAGATATTGCTGAACCCTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCTACAGGATGATTGATGCGTTAAAATCC
TGTTTCACGCAACAGGATATCGATTTTTTGCTGTCATTTAAACGAGGCGAACCAGACTGGCGGTTAGCGCCGGAAACACG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCGTTAG
ATAAACTGGAAAAGGTGTTGGCCGAGTGGCGCAGTTAG

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 12500.00 Da        Isoelectric Point: 4.9584

>AT238107 WP_241916229.1 NZ_CP093322:c1570163-1569816 [Yersinia intermedia]
MNNNTSTSPTWGLQCDITPRLGARLVQEGTHLHFLADRAGVVGTFAPDILQTLDTVFPVLIQHLEACLRSGELDQRCQHC
VTVQHGGFTCDADTLGSFGHLYIAVYQTTPSTDGE

Download         Length: 348 bp

>AT238107 NZ_LR890209:c4874938-4874180 [Klebsiella pneumoniae]
ATGTCATCAAAATTAAACTGGCTGCTGCAAAACAGTGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCGGCATGC
CATCTCTCCCTCTCTGGCCTTTAAATACACGCAAAGTGGCTGGTTAAAAAAACGAGGCAACGGCGTATACGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTAGCCGCTCCGGTGTATGTCGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGTCGTTCACACTATCTACAGCTCAAACAAAACCAGTGCTGGTTGAGTATGGAAAATAAAGCGCT
GCTGCCAAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGCAAAAACTGCCGGTGCTGGATGATA
AATACCGCGTAACGCTTGATGTAAAAGGGAAAAGACTCACCGGCAGTGCGCCGGAACTGGCTGCTTACGAGTTGTTGAGC
GCGGTACCGGGGACCCTCTCATTTAACCACGCGGCAGAGCTTTTCCAGGGACTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTGCTTTCTGTCAGCCAGTCCGTGCAGACCAAGCGTTTGTATCTCTTTTTCGCCAGTTTTTACGAGCATGGTTGGC
TCAGACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGTAAGCGGCAAATCGTGGTAAATGGCAAGTTCAATGCTCAA
TACCAAATCACTGTGCCTGAACGCTTTCAAAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References