Detailed information of TA system TA238105

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 1310928..1311463
• Replicon: chromosome
• Accession: NZ_CP093322
• Organism: Yersinia intermedia strain N6/293

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: MNQ97_RS05980
• Protein ID: WP_050133155.1
• Coordinates: 1311176..1311463 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A209ACY9
• Locus tag: MNQ97_RS05975
• Protein ID: WP_050084811.1
• Coordinates: 1310928..1311179 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MNQ97_RS05950 (MNQ97_05950)	1306355..1306858	+	504	WP_050084806.1	ferredoxin-type protein NapF	-
MNQ97_RS05955 (MNQ97_05955)	1306848..1307114	+	267	WP_032905977.1	chaperone NapD	-
MNQ97_RS05960 (MNQ97_05960)	1307111..1309606	+	2496	WP_050133149.1	nitrate reductase catalytic subunit NapA	-
MNQ97_RS05965 (MNQ97_05965)	1309702..1310169	+	468	WP_050084809.1	nitrate reductase cytochrome c-type subunit	-
MNQ97_RS05970 (MNQ97_05970)	1310198..1310797	+	600	WP_042568393.1	cytochrome c-type protein NapC	-
MNQ97_RS05975 (MNQ97_05975)	1310928..1311179	+	252	WP_050084811.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MNQ97_RS05980 (MNQ97_05980)	1311176..1311463	+	288	WP_050133155.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MNQ97_RS05985 (MNQ97_05985)	1311493..1312068	+	576	WP_050084918.1	GDP-mannose pyrophosphatase NudK	-
MNQ97_RS05990 (MNQ97_05990)	1312404..1314683	+	2280	WP_005183822.1	NADP-dependent oxaloacetate-decarboxylating malate dehydrogenase	-
MNQ97_RS05995 (MNQ97_05995)	1314862..1315320	-	459	WP_050084816.1	YaiI/YqxD family protein	-
MNQ97_RS06000 (MNQ97_06000)	1315320..1316246	-	927	WP_226715690.1	oxygen-dependent coproporphyrinogen oxidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11115.04 Da
• Isoelectric Point: 10.4702

>T238105 WP_050133155.1 NZ_CP093322:1311176-1311463 [Yersinia intermedia]
MTYAVKFREEALKEWHKLNKTIQQQFAKKLKKCSDNPHIESAKLRGMKNCYKIKLRSSGFRLVYEVIDDVLIVAVVAVGK
RDRSEVYNLASDRLR

Nucleotide

• Length: 288 bp

>T238105 NZ_LR890209:c2629113-2627791 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGCACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCGCTGCCGCTGCAGTATGGCAATATCACCG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTACCCGACAGCCCGCAGGTCCGCGATCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTGGGACGGGATAGCGTAGGGGCGGTGACTCTGCTACCGCCGGG
GGAAGAGGCGCACCTCGAGGGGTTGCGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCCTACCAGT
CGGATATCCCTCTCGGGATGATTACCGGCCAGGATGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGGGCACTGGTGTATTCCGCAGGGCACCACGCCGACCACGCATATCATTAAACTGCCCATCGGCGAGAT
AAAGCAGCCTAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAACGAGTTTCTGTGCCTGGCACTGGCCAGGGAACTGG
GCCTGGCGGTGCCGGAGGCAGAGATTATCACCACGCCGCGGATCCGCGCGCTGGCGGTGACCCGCTTTGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCCTTTGGCATCCCGTCGTCGATGAAATA
TGAATCTGACGGCGGGCCGGGTATTGCGGCAATCATGGCCTTTCTGCTGGGCTCCAGTGAAGCCCTGAAAGATCGCGCAG
ACTTTATGAAATTCATGGTTTTTCAGTGGCTGGTTGGGGCAACGGACGGGCATGCGAAGAACTTCTCGCTCTTTTTGCTG
CCCGGTGGCAGCTACCGTCTAACGCCGTTCTACGACATCATTTCGGCGTTTCCGGTGCTGGGAGGCACGGGACTGCATCT
GCGCGACCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGGAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCAACCGCCAAAGCGGTGAACTTTCCTGGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCTATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCACCCACGTCTGGCGGGCCATTACGGAGAATATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTACAGGCGTTATAG

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9283.62 Da
• Isoelectric Point: 4.3287

>AT238105 WP_050084811.1 NZ_CP093322:1310928-1311179 [Yersinia intermedia]
MPSIILTDTSASVSELKKNPMATVNAGAGFPVAILNRNQPVFYCVPAELYEQIMEALDDHELAELVNRRRHQPLLDIDLD
SYL

Nucleotide

• Length: 252 bp

>AT238105 NZ_LR890209:c2629379-2629113 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTATCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACACTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTAGGGGTGGTGATGACGCTGAACGCCAAAGCCACAGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A209ACY9