Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeV-yfjZ/CbtA-CbeA
Location 921073..921773 Replicon chromosome
Accession NZ_CP093322
Organism Yersinia intermedia strain N6/293

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag MNQ97_RS04170 Protein ID WP_241916132.1
Coordinates 921073..921444 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag MNQ97_RS04175 Protein ID WP_241916133.1
Coordinates 921441..921773 (+) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNQ97_RS04140 (MNQ97_04140) 916886..917440 + 555 WP_241916128.1 hypothetical protein -
MNQ97_RS04145 (MNQ97_04145) 917443..917934 + 492 WP_226721534.1 hypothetical protein -
MNQ97_RS04150 (MNQ97_04150) 918074..918340 + 267 WP_080608082.1 hypothetical protein -
MNQ97_RS04155 (MNQ97_04155) 918834..919655 + 822 WP_241916129.1 DUF932 domain-containing protein -
MNQ97_RS04160 (MNQ97_04160) 920016..920447 + 432 WP_241916130.1 antirestriction protein -
MNQ97_RS04165 (MNQ97_04165) 920467..920955 + 489 WP_241916131.1 DNA repair protein RadC -
MNQ97_RS04170 (MNQ97_04170) 921073..921444 + 372 WP_241916132.1 TA system toxin CbtA family protein Toxin
MNQ97_RS04175 (MNQ97_04175) 921441..921773 + 333 WP_241916133.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
MNQ97_RS04180 (MNQ97_04180) 921858..922706 + 849 WP_241916134.1 DUF4942 domain-containing protein -
MNQ97_RS04185 (MNQ97_04185) 923480..923995 - 516 WP_050135163.1 ClbS/DfsB family four-helix bundle protein -
MNQ97_RS04190 (MNQ97_04190) 924507..925751 + 1245 WP_050086361.1 sensor domain-containing diguanylate cyclase -
MNQ97_RS04195 (MNQ97_04195) 925834..926304 - 471 WP_241916135.1 Lrp/AsnC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(12-101)

Antitoxin

Antitoxin CbeA

(9-108)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13643.72 Da        Isoelectric Point: 6.8778

>T238104 WP_241916132.1 NZ_CP093322:921073-921444 [Yersinia intermedia]
MKPRPTPPGALPVPVIYQQLLAFLLEHHYGLSLNDTPYHDEQVIAQQIEQGISVGDTINTLVEKYALVRIGRNGFSALAQ
DPMLSKGDIARARQAAGLWRAHFPPTLLYPTEPLDPIPQRPLT

Download         Length: 372 bp

>T238104 NZ_LR890209:1869884-1869986 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12156.88 Da        Isoelectric Point: 7.4738

>AT238104 WP_241916133.1 NZ_CP093322:921441-921773 [Yersinia intermedia]
MNNHMTTSPTWGLKRDITPRLGARLIQEGTHLHFLSDRAHIVGTFSLEATQALDAAFPALITKLESQLLSGALDPRRQQG
ITVRHGEFVCEADTLGSHGYLYIAVYQKLA

Download         Length: 333 bp

>AT238104 NZ_LR890209:c1869993-1869848 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References