Detailed information of TA system TA238103

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 885548..886223
• Replicon: chromosome
• Accession: NZ_CP093322
• Organism: Yersinia intermedia strain N6/293

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: A0A208ZYD5
• Locus tag: MNQ97_RS03965
• Protein ID: WP_050086374.1
• Coordinates: 885795..886223 (+)
• Length: 143 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: -
• Locus tag: MNQ97_RS03960
• Protein ID: WP_050086375.1
• Coordinates: 885548..885814 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MNQ97_RS03940 (MNQ97_03940)	881672..882421	+	750	WP_050312389.1	SDR family oxidoreductase	-
MNQ97_RS03945 (MNQ97_03945)	882483..883091	-	609	WP_050086377.1	HD domain-containing protein	-
MNQ97_RS03950 (MNQ97_03950)	883482..884132	+	651	WP_226717746.1	hemolysin III family protein	-
MNQ97_RS03955 (MNQ97_03955)	884190..885182	-	993	WP_050086376.1	tRNA-modifying protein YgfZ	-
MNQ97_RS03960 (MNQ97_03960)	885548..885814	+	267	WP_050086375.1	FAD assembly factor SdhE	Antitoxin
MNQ97_RS03965 (MNQ97_03965)	885795..886223	+	429	WP_050086374.1	protein YgfX	Toxin
MNQ97_RS03970 (MNQ97_03970)	886220..886915	+	696	WP_050086373.1	two-component system response regulator CreB	-
MNQ97_RS03975 (MNQ97_03975)	886943..888370	+	1428	WP_241916110.1	two-component system sensor histidine kinase CreC	-
MNQ97_RS03980 (MNQ97_03980)	888463..889869	+	1407	WP_050086371.1	cell envelope integrity protein CreD	-
MNQ97_RS03985 (MNQ97_03985)	889920..890438	-	519	WP_005185992.1	flavodoxin FldB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-133)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 143 a.a.
• Molecular weight: 16578.41 Da
• Isoelectric Point: 10.3815

>T238103 WP_050086374.1 NZ_CP093322:885795-886223 [Yersinia intermedia]
VAQWRCDLRVSWHTQLFSLLSHGVLVILTLVAPWPQGYTALWLVLLTLVVFECIRSQKNITSCQGEIRLKPGNLVLWKRF
EWIVVKQPWITRYGVLLNLQQSSSRSARKRLWLAADSMSEDEWRQLCQLLRHSFGSDKGMNQ

Nucleotide

• Length: 429 bp

>T238103 NZ_LR890209:801625-802035 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTCCACGGCGTTGTGGCGGC
GCTGGTGCTGTTGGTTCCCTGGCCGCTAAGCTACACCCCGATCTGGCTGCTGCTGTTGTCGCTGGTAGTGTTTGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGAGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGCACGCCGTGGGTCATCAATAGCGGTATGCTGCTGCGTTTACGTCATGTCGATACCCGGCGCGG
GCAGCATCTGTGGCTGGCGGCGGATAGCATGGATGCCGGAGAATGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10489.98 Da
• Isoelectric Point: 5.1405

>AT238103 WP_050086375.1 NZ_CP093322:885548-885814 [Yersinia intermedia]
MEIDNKARIHWACRRGMRELDISIMPFFEHEYDGLSDNEKQAFIRLLECDDPDLFNWLMNHGEPQDNELRQMVKLIQTRN
KARGPVAM

Nucleotide

• Length: 267 bp

>AT238103 NZ_LR890209:801378-801644 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Toxin

• AlphaFold DB: A0A208ZYD5