Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 457226..458855 Replicon chromosome
Accession NZ_CP093322
Organism Yersinia intermedia strain N6/293

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag MNQ97_RS01975 Protein ID WP_050312663.1
Coordinates 457226..458554 (-) Length 443 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag MNQ97_RS01980 Protein ID WP_050312664.1
Coordinates 458556..458855 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNQ97_RS01960 (MNQ97_01960) 452815..453168 + 354 WP_032907677.1 MmcQ/YjbR family DNA-binding protein -
MNQ97_RS01965 (MNQ97_01965) 453307..456138 - 2832 WP_005191457.1 excinuclease ABC subunit UvrA -
MNQ97_RS01970 (MNQ97_01970) 456539..457087 + 549 WP_005191456.1 single-stranded DNA-binding protein SSB1 -
MNQ97_RS01975 (MNQ97_01975) 457226..458554 - 1329 WP_050312663.1 type II toxin-antitoxin system HipA family toxin Toxin
MNQ97_RS01980 (MNQ97_01980) 458556..458855 - 300 WP_050312664.1 helix-turn-helix transcriptional regulator Antitoxin
MNQ97_RS01985 (MNQ97_01985) 459125..459793 + 669 WP_005191448.1 glutathione S-transferase -
MNQ97_RS01990 (MNQ97_01990) 460268..461635 + 1368 WP_005191447.1 NCS2 family permease -
MNQ97_RS01995 (MNQ97_01995) 461853..463502 + 1650 WP_005191446.1 Na+/H+ antiporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(155-405)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-66)


Sequences

Toxin        


Download         Length: 443 a.a.        Molecular weight: 50205.16 Da        Isoelectric Point: 7.2905

>T238101 WP_050312663.1 NZ_CP093322:c458554-457226 [Yersinia intermedia]
MTRRIKRLNIWMNGQYVGYWEKTRGEESLVYAQEWIENAQGRPLSLSLPFTANNQVYRGNIVRDYFDNLLPDSDDIRRRL
ATRYHADSINPFDLLFELGRDCVGAIQLLANDTPPADLFSIQQQPLTEHDVARILRNSWSDNTFVRPEHNEDLRLSIAGA
QEKTALLFHDDRWCLPLGSTPTTHIFKLPLGLVGNMQADMRTSVENEWLCAKILASYNLPVARSEIGQFEDQKALIVERF
DRRLSRDNRWIVRLPQEDMCQASGTSPLKKYQIDGGPSITTIMGILSGSDNASEDRNLFFKTQIIFWLLAATDGHAKNFS
IAHLPRNSYHLTPLYDVLSTHPIIGSSHNQIAIQKAKLAMAVRGSKNYYLINQIQRRHWRKQAELVGLGAYLADSIIDEV
ITATPRVIAQIQAQLPANFPTDLAESILTGLHRQCDKIAAMP

Download         Length: 1329 bp

>T238101 NZ_LR890209:334952-335320 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGACCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCACCTGCTGGCGATTTCTCGCGGCCATATTTTCAATGATGGAAATAAGCGTACGGCACTGTTT
ATTACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAACCCGGACTTCGTCGGCATGAGCGTCGAGGCGGC
AGCGGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGCGGATGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11284.08 Da        Isoelectric Point: 8.9297

>AT238101 WP_050312664.1 NZ_CP093322:c458855-458556 [Yersinia intermedia]
MDYPIKILSQLRPTLIGFRKQKGLTQASLAQLLGITQQSYAKLEADPASASIERLFKVLQLLDVELILCEKKNVRLYSSK
THQPEESQTLNLPSKQEDW

Download         Length: 300 bp

>AT238101 NZ_LR890209:334734-334955 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGACAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCGGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATTATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References