Detailed information of TA system TA238098

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 4398124..4398586
• Replicon: chromosome
• Accession: NZ_CP093321
• Organism: Pseudomonas syringae CC440

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: N023_RS18985
• Protein ID: WP_080272594.1
• Coordinates: 4398305..4398586 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A3M3EVK6
• Locus tag: N023_RS18980
• Protein ID: WP_003319671.1
• Coordinates: 4398124..4398315 (+)
• Length: 64 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
N023_RS18960 (N023_18960)	4393204..4394466	-	1263	WP_024664883.1	MFS transporter	-
N023_RS18965 (N023_18965)	4394572..4395465	+	894	WP_003425485.1	LysR family transcriptional regulator	-
N023_RS18970 (N023_18970)	4395479..4396591	-	1113	WP_024664884.1	hypothetical protein	-
N023_RS18975 (N023_18975)	4396751..4398061	+	1311	WP_032623838.1	mechanosensitive ion channel family protein	-
N023_RS18980 (N023_18980)	4398124..4398315	+	192	WP_003319671.1	hypothetical protein	Antitoxin
N023_RS18985 (N023_18985)	4398305..4398586	+	282	WP_080272594.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
N023_RS18990 (N023_18990)	4398847..4399926	+	1080	WP_235202837.1	hypothetical protein	-
N023_RS18995 (N023_18995)	4400404..4401099	-	696	WP_152533119.1	hypothetical protein	-
N023_RS19000 (N023_19000)	4401839..4403503	+	1665	WP_024664888.1	DUF262 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-88)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10427.10 Da
• Isoelectric Point: 9.3696

>T238098 WP_080272594.1 NZ_CP093321:4398305-4398586 [Pseudomonas syringae CC440]
MLVEWRPAARMNLKQILSYIADRTVRATSELGMAIEVATSALPQHPYLYRHGLAPGTREIVVHPNYLVAYKVTDRIEVLA
VLHARQAYPTDAG

Nucleotide

• Length: 282 bp

>T238098 NZ_LR890205:53790-54272 [Klebsiella pneumoniae]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin

Protein

• Length: 64 a.a.
• Molecular weight: 7007.75 Da
• Isoelectric Point: 4.2322

>AT238098 WP_003319671.1 NZ_CP093321:4398124-4398315 [Pseudomonas syringae CC440]
MSARISPIVSEFETEEQAASYDKWFRAQVQASINDPAPNISHDQVMAEMRALLESKQPPSDAS

Nucleotide

• Length: 192 bp

>AT238098 NZ_LR890205:53536-53802 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Structures

Antitoxin

• AlphaFold DB: A0A3M3EVK6