Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /DUF1778(antitoxin) |
| Location | 3127282..3128081 | Replicon | chromosome |
| Accession | NC_012691 | ||
| Organism | Tolumonas auensis DSM 9187 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | C4LCD6 |
| Locus tag | TOLA_RS14595 | Protein ID | WP_015879889.1 |
| Coordinates | 3127282..3127815 (-) | Length | 178 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | C4LCD7 |
| Locus tag | TOLA_RS14600 | Protein ID | WP_015879890.1 |
| Coordinates | 3127812..3128081 (-) | Length | 90 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| TOLA_RS14565 | 3123617..3124438 | - | 822 | WP_015879883.1 | hypothetical protein | - |
| TOLA_RS14570 | 3124573..3125739 | - | 1167 | WP_015879884.1 | nucleotide sugar dehydrogenase | - |
| TOLA_RS14575 | 3125994..3126257 | - | 264 | WP_015879885.1 | Txe/YoeB family addiction module toxin | - |
| TOLA_RS14580 | 3126254..3126496 | - | 243 | WP_015879886.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| TOLA_RS14585 | 3126599..3126901 | - | 303 | WP_015879887.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| TOLA_RS14590 | 3126889..3127146 | - | 258 | WP_015879888.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| TOLA_RS14595 | 3127282..3127815 | - | 534 | WP_015879889.1 | GNAT family N-acetyltransferase | Toxin |
| TOLA_RS14600 | 3127812..3128081 | - | 270 | WP_015879890.1 | DUF1778 domain-containing protein | Antitoxin |
| TOLA_RS14605 | 3128333..3128581 | + | 249 | WP_015879891.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| TOLA_RS14610 | 3128571..3128861 | + | 291 | WP_015879892.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| TOLA_RS16720 | 3129086..3129304 | - | 219 | WP_015879893.1 | hypothetical protein | - |
| TOLA_RS14615 | 3129451..3129915 | - | 465 | WP_015879894.1 | hypothetical protein | - |
| TOLA_RS14620 | 3129919..3130323 | - | 405 | WP_015879895.1 | helix-turn-helix transcriptional regulator | - |
| TOLA_RS16725 | 3130326..3130715 | - | 390 | WP_148210457.1 | hypothetical protein | - |
| TOLA_RS14630 | 3131020..3132357 | - | 1338 | WP_015879896.1 | phosphoglucosamine mutase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 3126254..3142214 | 15960 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 178 a.a. Molecular weight: 20116.31 Da Isoelectric Point: 8.3243
>T23809 WP_015879889.1 NC_012691:c3127815-3127282 [Tolumonas auensis DSM 9187]
VNWSDQFVELDKSTHDRDSFDCGETELNELIQKFAAKHMHAGISRTMVLPATTALPDNKNPICAFYTIAPSSIRRESLPE
MLAKKLPRYPIPVFLLAQLAVHERYQGSGLGKIALIKALEYLWQVNGYLRAYAVVVDCLNEKAAQFYCKYGFELLCENNG
RKRMYLSMKTIGQLFSS
VNWSDQFVELDKSTHDRDSFDCGETELNELIQKFAAKHMHAGISRTMVLPATTALPDNKNPICAFYTIAPSSIRRESLPE
MLAKKLPRYPIPVFLLAQLAVHERYQGSGLGKIALIKALEYLWQVNGYLRAYAVVVDCLNEKAAQFYCKYGFELLCENNG
RKRMYLSMKTIGQLFSS
Download Length: 534 bp
>T23809 NC_012691:c3127815-3127282 [Tolumonas auensis DSM 9187]
GTGAACTGGTCTGATCAATTTGTTGAACTCGATAAATCGACTCACGACAGAGACTCTTTTGATTGTGGCGAAACCGAATT
AAATGAGCTCATTCAAAAATTTGCCGCGAAGCATATGCATGCGGGTATCAGCAGAACCATGGTGTTACCCGCAACAACGG
CGTTACCTGACAACAAAAATCCGATTTGTGCTTTTTATACTATTGCGCCAAGTTCCATTCGTCGTGAATCATTACCCGAG
ATGTTGGCTAAAAAATTACCACGTTATCCGATCCCTGTATTTTTACTGGCACAACTGGCTGTGCACGAACGTTATCAGGG
CAGTGGTTTAGGTAAAATTGCGCTCATCAAAGCGCTCGAATACTTGTGGCAGGTTAATGGCTATCTACGAGCCTATGCGG
TAGTTGTTGATTGCTTAAATGAGAAAGCTGCACAGTTTTACTGCAAATATGGTTTTGAATTGCTGTGTGAAAATAACGGC
AGAAAACGCATGTATCTTTCCATGAAAACCATCGGCCAACTGTTCAGCTCATAA
GTGAACTGGTCTGATCAATTTGTTGAACTCGATAAATCGACTCACGACAGAGACTCTTTTGATTGTGGCGAAACCGAATT
AAATGAGCTCATTCAAAAATTTGCCGCGAAGCATATGCATGCGGGTATCAGCAGAACCATGGTGTTACCCGCAACAACGG
CGTTACCTGACAACAAAAATCCGATTTGTGCTTTTTATACTATTGCGCCAAGTTCCATTCGTCGTGAATCATTACCCGAG
ATGTTGGCTAAAAAATTACCACGTTATCCGATCCCTGTATTTTTACTGGCACAACTGGCTGTGCACGAACGTTATCAGGG
CAGTGGTTTAGGTAAAATTGCGCTCATCAAAGCGCTCGAATACTTGTGGCAGGTTAATGGCTATCTACGAGCCTATGCGG
TAGTTGTTGATTGCTTAAATGAGAAAGCTGCACAGTTTTACTGCAAATATGGTTTTGAATTGCTGTGTGAAAATAACGGC
AGAAAACGCATGTATCTTTCCATGAAAACCATCGGCCAACTGTTCAGCTCATAA
Antitoxin
Download Length: 90 a.a. Molecular weight: 9844.22 Da Isoelectric Point: 4.6794
>AT23809 WP_015879890.1 NC_012691:c3128081-3127812 [Tolumonas auensis DSM 9187]
MATARLDLRIDEEVKAKAEKASALLGLKSLTEYVVRLMDENASKVISEHESITVNDDIFDQFMAACETAKEPNAALKNAL
SFTREQGIK
MATARLDLRIDEEVKAKAEKASALLGLKSLTEYVVRLMDENASKVISEHESITVNDDIFDQFMAACETAKEPNAALKNAL
SFTREQGIK
Download Length: 270 bp
>AT23809 NC_012691:c3128081-3127812 [Tolumonas auensis DSM 9187]
ATGGCTACTGCCCGATTAGATTTACGCATTGATGAAGAAGTCAAAGCTAAGGCCGAAAAAGCATCTGCTTTGCTTGGTCT
TAAAAGCTTAACTGAATATGTTGTTCGCCTTATGGATGAAAACGCCAGTAAAGTCATTTCCGAACACGAAAGCATTACAG
TTAATGATGACATTTTTGATCAATTCATGGCTGCATGTGAAACAGCTAAAGAGCCTAATGCCGCATTGAAAAATGCCCTC
TCCTTTACTCGGGAGCAAGGGATCAAGTGA
ATGGCTACTGCCCGATTAGATTTACGCATTGATGAAGAAGTCAAAGCTAAGGCCGAAAAAGCATCTGCTTTGCTTGGTCT
TAAAAGCTTAACTGAATATGTTGTTCGCCTTATGGATGAAAACGCCAGTAAAGTCATTTCCGAACACGAAAGCATTACAG
TTAATGATGACATTTTTGATCAATTCATGGCTGCATGTGAAACAGCTAAAGAGCCTAATGCCGCATTGAAAAATGCCCTC
TCCTTTACTCGGGAGCAAGGGATCAAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|