Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3779347..3779966 Replicon chromosome
Accession NZ_CP093314
Organism Klebsiella pneumoniae strain HUM7199

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag MLA24_RS18565 Protein ID WP_002892050.1
Coordinates 3779748..3779966 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag MLA24_RS18560 Protein ID WP_002892066.1
Coordinates 3779347..3779721 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MLA24_RS18550 (3774499) 3774499..3775692 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
MLA24_RS18555 (3775715) 3775715..3778861 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
MLA24_RS18560 (3779347) 3779347..3779721 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
MLA24_RS18565 (3779748) 3779748..3779966 + 219 WP_002892050.1 HHA domain-containing protein Toxin
MLA24_RS18570 (3780125) 3780125..3780691 + 567 WP_002892030.1 maltose O-acetyltransferase -
MLA24_RS18575 (3780663) 3780663..3780803 - 141 WP_004147370.1 hypothetical protein -
MLA24_RS18580 (3780824) 3780824..3781294 + 471 WP_002892026.1 YlaC family protein -
MLA24_RS18585 (3781269) 3781269..3782720 - 1452 WP_032435563.1 PLP-dependent aminotransferase family protein -
MLA24_RS18590 (3782821) 3782821..3783519 + 699 WP_032435564.1 GNAT family protein -
MLA24_RS18595 (3783516) 3783516..3783656 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
MLA24_RS18600 (3783656) 3783656..3783919 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T238061 WP_002892050.1 NZ_CP093314:3779748-3779966 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T238061 NZ_LR890198:4268489-4268827 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCTCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CTGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGAAGAGAGCAAA
CTGATGCAGTCACTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAAGCAGGTGCAGGAGTTTATTGGGGTGATTAG
TAGCAAAACGCCACGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT238061 WP_002892066.1 NZ_CP093314:3779347-3779721 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT238061 NZ_LR890198:c4268471-4268418 [Escherichia coli]
AATAGGGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References