Detailed information of TA system TA238060

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2648353..2649941
• Replicon: chromosome
• Accession: NZ_CP093314
• Organism: Klebsiella pneumoniae strain HUM7199

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A9J6RYF8
• Locus tag: MLA24_RS12980
• Protein ID: WP_004892016.1
• Coordinates: 2648353..2649675 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: MLA24_RS12985
• Protein ID: WP_004176198.1
• Coordinates: 2649675..2649941 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MLA24_RS12965 (2643409)	2643409..2645910	+	2502	WP_032435337.1	fimbria/pilus outer membrane usher protein	-
MLA24_RS12970 (2645898)	2645898..2646902	+	1005	WP_032435338.1	fimbrial protein	-
MLA24_RS12975 (2647044)	2647044..2648336	+	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
MLA24_RS12980 (2648353)	2648353..2649675	-	1323	WP_004892016.1	type II toxin-antitoxin system HipA family toxin	Toxin
MLA24_RS12985 (2649675)	2649675..2649941	-	267	WP_004176198.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
MLA24_RS12990 (2650328)	2650328..2650654	-	327	WP_004184023.1	hydroxyisourate hydrolase	-
MLA24_RS12995 (2650651)	2650651..2651151	-	501	WP_032435339.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
MLA24_RS13000 (2651129)	2651129..2652508	-	1380	WP_004184021.1	nucleobase:cation symporter-2 family protein	-
MLA24_RS13005 (2652854)	2652854..2654008	+	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
MLA24_RS13010 (2653989)	2653989..2654912	-	924	WP_008804925.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49141.44 Da
• Isoelectric Point: 7.5357

>T238060 WP_004892016.1 NZ_CP093314:c2649675-2648353 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T238060 NZ_LR890198:c4260549-4260262 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGCAAACAAGGCCAAAAGTAATCGGGTAAAACATGGCATCCGCTTTGAAGATGCGGT
GTTAGTGTTTGATGATCCACAACATTTGTCACAGCAAGATCGCATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9936.36 Da
• Isoelectric Point: 8.5912

>AT238060 WP_004176198.1 NZ_CP093314:c2649941-2649675 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT238060 NZ_LR890198:c4260275-4259973 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCGCTGGCGAA
CAAATTCGACGAGGATATTGATTACAGCGACATCCCATCTTCCAGCGATGAGCAATGGTCTAACGCCGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCTGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA