Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 6162532..6163124 Replicon chromosome
Accession NZ_CP093313
Organism Occallatibacter riparius strain DSM 25168

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag MOP44_RS25165 Protein ID WP_260793275.1
Coordinates 6162532..6162882 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag MOP44_RS25170 Protein ID WP_260793277.1
Coordinates 6162876..6163124 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOP44_RS25145 (MOP44_25080) 6157932..6158114 + 183 Protein_4983 hypothetical protein -
MOP44_RS25150 (MOP44_25085) 6158316..6159200 + 885 WP_260796728.1 hypothetical protein -
MOP44_RS25155 (MOP44_25090) 6159451..6161778 + 2328 WP_260793272.1 glycoside hydrolase family 3 C-terminal domain-containing protein -
MOP44_RS25160 (MOP44_25095) 6161819..6162430 - 612 WP_260793273.1 hypothetical protein -
MOP44_RS25165 (MOP44_25100) 6162532..6162882 - 351 WP_260793275.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MOP44_RS25170 (MOP44_25105) 6162876..6163124 - 249 WP_260793277.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
MOP44_RS25175 (MOP44_25110) 6163255..6163665 + 411 WP_260793279.1 hypothetical protein -
MOP44_RS25180 (MOP44_25115) 6163721..6165256 - 1536 WP_260793281.1 hypothetical protein -
MOP44_RS25185 (MOP44_25120) 6165350..6166258 - 909 WP_260793282.1 DMT family transporter -
MOP44_RS25190 (MOP44_25125) 6166581..6167537 + 957 WP_260793284.1 aldo/keto reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(9-109)

Antitoxin

Antitoxin PemI-like

(1-80)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12629.85 Da        Isoelectric Point: 10.2270

>T238047 WP_260793275.1 NZ_CP093313:c6162882-6162532 [Occallatibacter riparius]
VVKPYVPDAGDIVMLDFDPQVGREQAKRRPALVLTDVRYNRASGLAVVCPLTSKRKPYPFALPINVGGVEGAVLADQLKS
LDWAGRHADFHSKVAPAMLTKVRQYVAVLLAIPVKP

Download         Length: 351 bp

>T238047 NZ_LR890198:1148938-1149273 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATACGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTCTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTGCTGATTGGGTAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8936.16 Da        Isoelectric Point: 4.7499

>AT238047 WP_260793277.1 NZ_CP093313:c6163124-6162876 [Occallatibacter riparius]
MRAQILKWGNSLAVRIPKPIAEQASLSEGDPIEIEVSGQGSLQLHRGGKIPTLAQLVAQITPENRYEEIGTGPEFGKEAV
EW

Download         Length: 249 bp

>AT238047 NZ_LR890198:1148690-1148938 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGGGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References