Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 4318494..4319113 Replicon chromosome
Accession NZ_CP093313
Organism Occallatibacter riparius strain DSM 25168

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MOP44_RS17525 Protein ID WP_260791542.1
Coordinates 4318721..4319113 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MOP44_RS17520 Protein ID WP_260791541.1
Coordinates 4318494..4318724 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOP44_RS17505 (MOP44_17465) 4315278..4316123 + 846 WP_260791538.1 CPBP family intramembrane metalloprotease -
MOP44_RS17510 (MOP44_17470) 4316480..4317907 + 1428 WP_260791539.1 transporter substrate-binding domain-containing protein -
MOP44_RS17515 (MOP44_17475) 4317986..4318420 + 435 WP_260791540.1 hypothetical protein -
MOP44_RS17520 (MOP44_17480) 4318494..4318724 + 231 WP_260791541.1 hypothetical protein Antitoxin
MOP44_RS17525 (MOP44_17485) 4318721..4319113 + 393 WP_260791542.1 type II toxin-antitoxin system VapC family toxin Toxin
MOP44_RS17530 (MOP44_17490) 4319120..4319530 - 411 WP_260791543.1 large conductance mechanosensitive channel protein MscL -
MOP44_RS17535 (MOP44_17495) 4319594..4319887 - 294 WP_260791544.1 permease -
MOP44_RS17540 (MOP44_17500) 4319984..4320439 + 456 WP_260791545.1 VOC family protein -
MOP44_RS17545 (MOP44_17505) 4320529..4322223 + 1695 WP_260791546.1 serine/threonine-protein kinase -
MOP44_RS17550 (MOP44_17510) 4322368..4323417 - 1050 WP_260791547.1 S-methyl-5-thioribose-1-phosphate isomerase -
MOP44_RS17555 (MOP44_17515) 4323455..4323859 - 405 WP_260791548.1 response regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(3-116)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14772.14 Da        Isoelectric Point: 8.5513

>T238045 WP_260791542.1 NZ_CP093313:4318721-4319113 [Occallatibacter riparius]
MIVLDASAAVDWLLRTTAGQRIEQRIYQQPETLHTLHLLDVEFVQVLRRLVREGTLAPKRAQEAIEDLAALRITRYAPVL
LLQRIWRLRQNLSAYDASYVALAEELRAPLITRDHRIAAAPGHAAAVEIF

Download         Length: 393 bp

>T238045 NZ_LR890198:c816935-816561 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGAAACGATGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8608.87 Da        Isoelectric Point: 8.8113

>AT238045 WP_260791541.1 NZ_CP093313:4318494-4318724 [Occallatibacter riparius]
MERMIQVRNVPETLHRALKTRAASAGMSLSDYLLGELREIAERPNLAEFRERLHTRRPISATLDTAALLHEERAAG

Download         Length: 231 bp

>AT238045 NZ_LR890198:c817393-817025 [Escherichia coli]
GTGTCAGACGCACTCTCCGGGACAATGCTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGTCTGACCTGCAAAGCTGACACTCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References