Detailed information of TA system TA238042

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 2047764..2049334
• Replicon: chromosome
• Accession: NZ_CP093313
• Organism: Occallatibacter riparius strain DSM 25168

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: MOP44_RS08070
• Protein ID: WP_260795501.1
• Coordinates: 2047764..2049086 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: MOP44_RS08075
• Protein ID: WP_260795502.1
• Coordinates: 2049086..2049334 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MOP44_RS08040 (MOP44_08015)	2043876..2044262	-	387	WP_260795496.1	hypothetical protein	-
MOP44_RS08050 (MOP44_08025)	2044958..2045719	-	762	WP_260795497.1	hypothetical protein	-
MOP44_RS08055 (MOP44_08030)	2045872..2046306	+	435	WP_260795498.1	dUTP diphosphatase	-
MOP44_RS08060 (MOP44_08035)	2046379..2046807	+	429	WP_260795499.1	DUF3291 domain-containing protein	-
MOP44_RS08065 (MOP44_08040)	2046829..2047761	+	933	WP_260795500.1	NAD-dependent epimerase/dehydratase family protein	-
MOP44_RS08070 (MOP44_08045)	2047764..2049086	-	1323	WP_260795501.1	type II toxin-antitoxin system HipA family toxin	Toxin
MOP44_RS08075 (MOP44_08050)	2049086..2049334	-	249	WP_260795502.1	helix-turn-helix domain-containing protein	Antitoxin
MOP44_RS08080 (MOP44_08055)	2049473..2050873	-	1401	WP_260795504.1	tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (9-108)

Antitoxin

• Cro/C1-type helix-turn-helix domain (12-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49071.11 Da
• Isoelectric Point: 7.0990

>T238042 WP_260795501.1 NZ_CP093313:c2049086-2047764 [Occallatibacter riparius]
MPRTRYEPLNVFLNSRLVGQLRRDVSGAISFKYDQSWLEWEFVMPVSLSLPLRAQTYSGAPVIAVFDNLLPDNDDLRRQI
AARTHAEGTDAYSLLGAIGHDCVGALQFLPQNIEPLPAGSVQGDPVSNDEIALIIENLAAAPLGISEDESFRISIAGAQE
KTAFLYRDRKWYKPRGTTATTHIFKPSIGMLPNGMDLTSSVENEYFCLKVVAALGIEAAQPQIMTFGKRTVLVVERFDRR
WTADERLLRLPQEDCCQALSISPTRKYQAHGGPGIVQILQLLRGSDDAPADQRAFLKANIIFWLMGATDGHAKNFSVFLR
PGGRFRLTPLYDVISAQPSVDSKQLLWKNFSLAMSFGTKPHYKMRQIAPRHFFQTADEAGMGKEVVPSIIEELRAEAERE
IDRVNADLPQNFPVAVADSISNGIRRRLRILEEGVEKKSS

Nucleotide

• Length: 1323 bp

>T238042 NZ_LR890193:71569-72054 [Klebsiella pneumoniae]
GTGGGATATGTAACATCACCAGAACCGTTGTCTTCTTTTCATCAGGTGGCGGAGTTTATCAGCGGTGAAGCCGTGCTTGA
TGACTGGTTAAAGCAGAGGAGCCTCAAAAACCAGGCGACTGGAGCGGCCCGAACGTTTGTGGTGTGTAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGGAGCGTCAATCATACAGAAGCGACAGGCAATCTTCGGCGTAACATG
CCAGATCCCATTCCTGTCATTATACTTGCCAGGCTTGCCGTCGATGTATCGTTCCGTGGAAAAGGGCTTGGTGCTGATTT
GCTTCATGACGCAGTGCTTCGTTGCTTTCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCACGCGCTTACGG
AAGAAGCCAAAAACTTCTATATTCATCATGGTTTCAAACCATCACAAAGTCAGCCACGGACATTGTTCCTCAGACTCCCT
CAGTAA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9099.47 Da
• Isoelectric Point: 10.7279

>AT238042 WP_260795502.1 NZ_CP093313:c2049334-2049086 [Occallatibacter riparius]
MDTIARTPLQLGNAIRESRRKLRWTQEQLAAKVGVRQKTVSDIENAGAGRLDTLLRALGALDLELVIRPRTKSSADDIEA
IF

Nucleotide

• Length: 249 bp

>AT238042 NZ_LR890193:71315-71581 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTTAACCTCAGAGCCAAGGAATCCCAGCGAGCACTCATTGATGCTGCTGCTGAAATCCTTCA
CAAATCACGAACAGATTTCATTCTGGAAATGGCCTGTAAGGCTGCCGAGGATGTCATCCTTGACCGCCGCGTCTTTAATT
TTAACGATGAGCAATACGCCGAGTTCATCGATATGATTGATGCGCCGGTTGCAGATGATCCTGCTATCGAAAAACTGCTG
GCAAGGAAACCTCAGTGGGATATGTAA