Detailed information of TA system TA238041

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 1486500..1488057
• Replicon: chromosome
• Accession: NZ_CP093311
• Organism: Thermomonas paludicola strain IMCC34681

Toxin (Protein)

• Gene name: HipA1
• Uniprot ID: -
• Locus tag: LIW09_RS06910
• Protein ID: WP_256644924.1
• Coordinates: 1486500..1487807 (-)
• Length: 436 a.a.

Antitoxin (Protein)

• Gene name: HipB1
• Uniprot ID: -
• Locus tag: LIW09_RS06915
• Protein ID: WP_256644925.1
• Coordinates: 1487797..1488057 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LIW09_RS06900	1484030..1485136	-	1107	WP_256644922.1	alpha/beta hydrolase	-
LIW09_RS06905	1485232..1486107	+	876	WP_256644923.1	helix-turn-helix domain-containing protein	-
LIW09_RS06910	1486500..1487807	-	1308	WP_256644924.1	type II toxin-antitoxin system HipA family toxin	Toxin
LIW09_RS06915	1487797..1488057	-	261	WP_256644925.1	helix-turn-helix transcriptional regulator	Antitoxin
LIW09_RS06920	1488278..1489387	-	1110	WP_256644926.1	MFS transporter	-
LIW09_RS06925	1489500..1489814	-	315	Protein_1355	YnfA family protein	-
LIW09_RS06930	1489811..1490794	-	984	WP_256644927.1	CDF family Co(II)/Ni(II) efflux transporter DmeF	-
LIW09_RS06935	1490879..1491043	+	165	WP_256644928.1	hypothetical protein	-
LIW09_RS06940	1491174..1491395	+	222	WP_256644929.1	metal/formaldehyde-sensitive transcriptional repressor	-
LIW09_RS06945	1491533..1491778	+	246	WP_256644930.1	hypothetical protein	-
LIW09_RS06955	1492289..1492861	-	573	Protein_1360	OmpA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (5-102)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-65)

Sequences

Toxin

Protein

• Length: 436 a.a.
• Molecular weight: 47858.99 Da
• Isoelectric Point: 6.7158

>T238041 WP_256644924.1 NZ_CP093311:c1487807-1486500 [Thermomonas paludicola]
MAHELEVWLFADRVGTLALVDGRLNFCYAPDWLSHKDAVALSASLPLQAEPFDDRKTRPFFAGLLPEGQMRRLIAQQFQV
SGQNDFALLDHIGGECAGAVTFLEPGQALPVPTRTDDVQWLSDDEVVAILDELPRRPMLAGKDGLRLSLAGAQDKLPVVF
DGTRIGLPLNGTPSSHILKPAIHAVEDSVINEGFCMVLAEAMQLKPAKSKVHWVLDRSFLLVERYDRLIDAQGHRQRLHQ
EDLCQALGVVPEMKYQNEGGPDLAQCFALVRSATRPSAPQVLRLLDCVIFNALIGNHDAHAKNFSLLYLDGKSGTAPVLA
PFYDTLSTAVYPTLTQKMAMKIGSKYKFSEVQARHWEQFAEGVGFTKAQAKRRILELAKLLPATARKLQSDPGRRFAGNA
VVEQINTLIEQRCALTIRRLTDPAAGNDAAAEPSV

Nucleotide

• Length: 1308 bp

>T238041 NZ_LR890193:c39404-38988 [Klebsiella pneumoniae]
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9058.33 Da
• Isoelectric Point: 9.0010

>AT238041 WP_256644925.1 NZ_CP093311:c1488057-1487797 [Thermomonas paludicola]
MTSIRSPQQLGDALRAARKQLGLTQPRLALAAGVGVRFIVDLEAGKPTLRLENVLRVVDALGGEIQLSGLPSSVTDDQRE
GGNHGT

Nucleotide

• Length: 261 bp

>AT238041 NZ_LR890193:c39631-39401 [Klebsiella pneumoniae]
ATGAGAACTGTATCCATTTTTAAAAACGGCAATAACCGCGCCATTCGTCTGCCCCGCGATCTGGATTTTGAGGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATTATTTTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGTTCG
AGAAGGCAGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA