Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemK-mazE/MazF(toxin)
Location 2591325..2591958 Replicon chromosome
Accession NZ_CP093301
Organism Evansella sp. LMS18

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag MM300_RS12245 Protein ID WP_078592678.1
Coordinates 2591608..2591958 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag MM300_RS12240 Protein ID WP_078592679.1
Coordinates 2591325..2591603 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MM300_RS12220 (MM300_12180) 2586751..2588277 + 1527 WP_255241242.1 NAD(P)H-hydrate dehydratase -
MM300_RS12225 (MM300_12185) 2588327..2589358 + 1032 WP_255241243.1 outer membrane lipoprotein carrier protein LolA -
MM300_RS12230 (MM300_12190) 2589433..2589639 + 207 WP_255241244.1 hypothetical protein -
MM300_RS12235 (MM300_12195) 2589904..2591070 + 1167 WP_255241245.1 alanine racemase -
MM300_RS12240 (MM300_12200) 2591325..2591603 + 279 WP_078592679.1 antitoxin Antitoxin
MM300_RS12245 (MM300_12205) 2591608..2591958 + 351 WP_078592678.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MM300_RS12250 (MM300_12210) 2592125..2593255 + 1131 WP_255241246.1 zinc-dependent alcohol dehydrogenase -
MM300_RS12255 (MM300_12215) 2593594..2594427 + 834 WP_255241247.1 RsbT co-antagonist protein RsbRA -
MM300_RS12260 (MM300_12220) 2594443..2594799 + 357 WP_078592675.1 STAS domain-containing protein -
MM300_RS12265 (MM300_12225) 2594802..2595203 + 402 WP_078592674.1 anti-sigma regulatory factor -
MM300_RS12270 (MM300_12230) 2595239..2596231 + 993 WP_255245302.1 PP2C family protein-serine/threonine phosphatase -
MM300_RS12275 (MM300_12235) 2596295..2596624 + 330 WP_078592672.1 STAS domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12979.07 Da        Isoelectric Point: 6.4662

>T238037 WP_078592678.1 NZ_CP093301:2591608-2591958 [Evansella sp. LMS18]
MIVKRGDVYFADLSPVVGSEQGGIRPVLIIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEINAKRYGFDRDSVILLEQV
RTIDKQRLTDKITHLDDDMMTRVNDALMISLGLIDF

Download         Length: 351 bp

>T238037 NZ_LR890189:c4834881-4833964 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGCGTA
TTTACTGAGCCATAATCGGCCTCTGGTTGAAGTGCTGAGTCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10629.11 Da        Isoelectric Point: 4.6865

>AT238037 WP_078592679.1 NZ_CP093301:2591325-2591603 [Evansella sp. LMS18]
VSEENTKKIMVSLPQHLVNELDGLLEQQNINRNEVIHQATKMYLKEQKKQQIRETMQQGYMEMAKINLNIATEAFLAEEE
AENTLDRLVSGV

Download         Length: 279 bp

>AT238037 NZ_LR890189:c4835645-4834887 [Klebsiella pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGGCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References