Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 245526..246176 Replicon chromosome
Accession NZ_CP093300
Organism Alkalihalobacillus sp. LMS39

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag MM271_RS01345 Protein ID WP_026675763.1
Coordinates 245826..246176 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag MM271_RS01340 Protein ID WP_279390783.1
Coordinates 245526..245822 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MM271_RS01320 (MM271_01320) 241117..241869 - 753 WP_243530657.1 rhomboid family intramembrane serine protease -
MM271_RS01325 (MM271_01325) 241977..242330 + 354 WP_243530660.1 holo-ACP synthase -
MM271_RS01330 (MM271_01330) 242878..243903 + 1026 WP_243530663.1 outer membrane lipoprotein carrier protein LolA -
MM271_RS01335 (MM271_01335) 244255..245430 + 1176 WP_243530665.1 alanine racemase -
MM271_RS01340 (MM271_01340) 245526..245822 + 297 WP_279390783.1 antitoxin Antitoxin
MM271_RS01345 (MM271_01345) 245826..246176 + 351 WP_026675763.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MM271_RS01350 (MM271_01350) 246323..247141 + 819 WP_243530669.1 RsbT co-antagonist protein RsbRA -
MM271_RS01355 (MM271_01355) 247157..247513 + 357 WP_026675765.1 STAS domain-containing protein -
MM271_RS01360 (MM271_01360) 247518..247928 + 411 WP_026675766.1 anti-sigma regulatory factor -
MM271_RS01365 (MM271_01365) 247940..248965 + 1026 WP_279390784.1 PP2C family protein-serine/threonine phosphatase -
MM271_RS01370 (MM271_01370) 249020..249361 + 342 WP_243530671.1 STAS domain-containing protein -
MM271_RS01375 (MM271_01375) 249358..249840 + 483 WP_243530674.1 anti-sigma B factor RsbW -
MM271_RS01380 (MM271_01380) 249803..250588 + 786 WP_243530676.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12961.98 Da        Isoelectric Point: 6.4662

>T238036 WP_026675763.1 NZ_CP093300:245826-246176 [Alkalihalobacillus sp. LMS39]
MIVKRGDVYFADLSPVVGSEQGGVRPVLIIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEINAKRYGFDRDSVILLEQI
RTIDKQRLTDKITHLDDDMMSRVNDALQISLGLIDF

Download         Length: 351 bp

>T238036 NZ_LR890189:c4675785-4675501 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11407.14 Da        Isoelectric Point: 7.2033

>AT238036 WP_279390783.1 NZ_CP093300:245526-245822 [Alkalihalobacillus sp. LMS39]
MLGGFFVSENSTKRIMVNLPQHILNEVDGVIKQENVNRSEFIYQATKMYLRERKKRKIRETMQQGYMEMAKINLNIASEA
FLAEEEAEHTLDRLVSGV

Download         Length: 297 bp

>AT238036 NZ_LR890189:c4676017-4675775 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References