Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazEF/MazF(toxin) |
| Location | 1870910..1871547 | Replicon | chromosome |
| Accession | NZ_CP093298 | ||
| Organism | Bacillus amyloliquefaciens strain MN-13 | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | G4NU33 |
| Locus tag | MNY35_RS08845 | Protein ID | WP_003156187.1 |
| Coordinates | 1870910..1871260 (-) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | I2HMS5 |
| Locus tag | MNY35_RS08850 | Protein ID | WP_003156188.1 |
| Coordinates | 1871266..1871547 (-) | Length | 94 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MNY35_RS08805 (MNY35_08805) | 1865950..1866552 | - | 603 | WP_039252641.1 | PP2C family serine/threonine-protein phosphatase | - |
| MNY35_RS08810 (MNY35_08810) | 1866552..1867340 | - | 789 | WP_003156171.1 | RNA polymerase sigma factor SigB | - |
| MNY35_RS08815 (MNY35_08815) | 1867306..1867788 | - | 483 | WP_007609591.1 | anti-sigma B factor RsbW | - |
| MNY35_RS08820 (MNY35_08820) | 1867785..1868114 | - | 330 | WP_031378636.1 | anti-sigma factor antagonist | - |
| MNY35_RS08825 (MNY35_08825) | 1868178..1869185 | - | 1008 | WP_039252645.1 | PP2C family protein-serine/threonine phosphatase | - |
| MNY35_RS08830 (MNY35_08830) | 1869197..1869598 | - | 402 | WP_003156178.1 | anti-sigma regulatory factor | - |
| MNY35_RS08835 (MNY35_08835) | 1869601..1869966 | - | 366 | WP_003156180.1 | RsbT antagonist protein RsbS | - |
| MNY35_RS08840 (MNY35_08840) | 1869971..1870792 | - | 822 | WP_003156182.1 | STAS domain-containing protein | - |
| MNY35_RS08845 (MNY35_08845) | 1870910..1871260 | - | 351 | WP_003156187.1 | type II toxin-antitoxin system endoribonuclease NdoA | Toxin |
| MNY35_RS08850 (MNY35_08850) | 1871266..1871547 | - | 282 | WP_003156188.1 | type II toxin-antitoxin system antitoxin EndoAI | Antitoxin |
| MNY35_RS08855 (MNY35_08855) | 1871667..1872836 | - | 1170 | WP_039252648.1 | alanine racemase | - |
| MNY35_RS08860 (MNY35_08860) | 1872953..1873960 | - | 1008 | WP_007410230.1 | outer membrane lipoprotein carrier protein LolA | - |
| MNY35_RS08865 (MNY35_08865) | 1874125..1874490 | - | 366 | WP_007410229.1 | holo-ACP synthase | - |
| MNY35_RS08870 (MNY35_08870) | 1874583..1875182 | + | 600 | WP_003156193.1 | rhomboid family intramembrane serine protease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 12977.98 Da Isoelectric Point: 4.8781
>T238034 WP_003156187.1 NZ_CP093298:c1871260-1870910 [Bacillus amyloliquefaciens]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLALIDF
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLALIDF
Download Length: 351 bp
>T238034 NZ_LR890189:3971590-3971808 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA
Antitoxin
Download Length: 94 a.a. Molecular weight: 10562.92 Da Isoelectric Point: 6.4706
>AT238034 WP_003156188.1 NZ_CP093298:c1871547-1871266 [Bacillus amyloliquefaciens]
MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAYVSERTTRHNRDLMRRGYMEMAKINLNISSEAHYAEC
EAETTVERLVSGG
MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAYVSERTTRHNRDLMRRGYMEMAKINLNISSEAHYAEC
EAETTVERLVSGG
Download Length: 282 bp
>AT238034 NZ_LR890189:3971189-3971563 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAACTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAACTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|