Detailed information of TA system TA023803

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1984329..1984889
• Replicon: chromosome
• Accession: NC_012691
• Organism: Tolumonas auensis DSM 9187

Toxin (Protein)

• Gene name: relE
• Uniprot ID: C4LFQ5
• Locus tag: TOLA_RS09210
• Protein ID: WP_015878893.1
• Coordinates: 1984329..1984607 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: C4LFQ6
• Locus tag: TOLA_RS09215
• Protein ID: WP_015878894.1
• Coordinates: 1984611..1984889 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TOLA_RS09190	1979492..1981525	-	2034	WP_015878889.1	glycoside hydrolase family 3 protein	-
TOLA_RS09195	1981974..1982633	+	660	WP_015878890.1	NYN domain-containing protein	-
TOLA_RS09200	1982931..1983479	+	549	WP_041609821.1	hypothetical protein	-
TOLA_RS09205	1983593..1984174	+	582	WP_041609505.1	hypothetical protein	-
TOLA_RS09210	1984329..1984607	-	279	WP_015878893.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
TOLA_RS09215	1984611..1984889	-	279	WP_015878894.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
TOLA_RS09220	1985048..1985686	+	639	WP_015878895.1	NAD(P)H-dependent oxidoreductase	-
TOLA_RS09225	1986118..1986426	-	309	WP_015878896.1	copper-binding protein	-
TOLA_RS16680	1986825..1986971	+	147	WP_148210440.1	PAAR domain-containing protein	-
TOLA_RS09230	1986978..1987310	+	333	WP_015878897.1	type II toxin-antitoxin system RelE/ParE family toxin	-
TOLA_RS09235	1987297..1987611	+	315	WP_015878898.1	DNA-binding transcriptional regulator	-
TOLA_RS09240	1987734..1988165	+	432	WP_015878899.1	DedA family protein	-
TOLA_RS09245	1988170..1988517	-	348	WP_015878900.1	hypothetical protein	-
TOLA_RS09250	1988685..1989149	+	465	WP_015878901.1	Rrf2 family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (1-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-74)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10962.70 Da
• Isoelectric Point: 4.5593

>T23803 WP_015878893.1 NC_012691:c1984607-1984329 [Tolumonas auensis DSM 9187]
MIYWEEEALNDREKIFEFLYEFNPVAAEKTDEIIDAKVENLLEQPLMGVRRSGLRGRLLIIPEVSMIVSYRFDDADIYVM
RVLHQKQKFPIQ

Nucleotide

• Length: 279 bp

>T23803 NC_012691:c1984607-1984329 [Tolumonas auensis DSM 9187]
ATGATTTATTGGGAAGAAGAAGCTCTGAATGATCGGGAAAAAATTTTTGAGTTTCTTTATGAGTTTAACCCTGTTGCAGC
CGAAAAGACGGACGAAATAATAGATGCAAAAGTTGAAAATCTGCTGGAGCAGCCCTTGATGGGCGTCAGACGTAGTGGCC
TAAGGGGCCGGCTGCTGATCATCCCGGAGGTATCAATGATAGTGTCTTACCGATTTGATGATGCAGATATCTATGTCATG
CGAGTGCTTCACCAGAAACAGAAATTCCCGATTCAATAA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10689.11 Da
• Isoelectric Point: 7.2806

>AT23803 WP_015878894.1 NC_012691:c1984889-1984611 [Tolumonas auensis DSM 9187]
MDTRIQFRIDEETKHLAQLMAESQGRTLSDACRQLTEQLADEQRKIMAHDAWLTEQVNMAFEKLDSGNAVFLTHEQAQKR
MAERKAKIRSRG

Nucleotide

• Length: 279 bp

>AT23803 NC_012691:c1984889-1984611 [Tolumonas auensis DSM 9187]
ATGGATACCAGAATTCAATTTCGTATTGATGAAGAAACGAAACATCTGGCACAGCTTATGGCTGAAAGCCAGGGGCGTAC
ATTAAGTGATGCCTGCCGTCAGTTAACAGAACAACTCGCTGACGAACAAAGAAAAATCATGGCACACGATGCATGGCTAA
CAGAGCAAGTGAATATGGCGTTTGAAAAACTGGATTCAGGAAACGCTGTGTTTCTAACGCATGAACAAGCTCAAAAACGA
ATGGCAGAACGTAAAGCAAAAATTCGCAGCAGAGGCTAA

Structures

Toxin

• AlphaFold DB: C4LFQ5

Antitoxin

• AlphaFold DB: C4LFQ6