Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH
Location 836581..837280 Replicon plasmid p1
Accession NZ_CP093281
Organism Pseudomonas sp. T1-3-2

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag LZ023_RS39965 Protein ID WP_268152297.1
Coordinates 836900..837280 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A9E8WGG5
Locus tag LZ023_RS39960 Protein ID WP_058960952.1
Coordinates 836581..836907 (-) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZ023_RS39935 (LZ023_39760) 832409..833371 + 963 WP_268152294.1 AraC family transcriptional regulator -
LZ023_RS39940 (LZ023_39765) 833474..833975 - 502 Protein_1051 GNAT family N-acetyltransferase -
LZ023_RS39945 (LZ023_39770) 834031..834608 + 578 Protein_1052 helix-turn-helix transcriptional regulator -
LZ023_RS39950 (LZ023_39775) 834612..835548 - 937 Protein_1053 AraC family transcriptional regulator -
LZ023_RS39955 (LZ023_39780) 835657..836489 + 833 Protein_1054 oxidoreductase -
LZ023_RS39960 (LZ023_39785) 836581..836907 - 327 WP_058960952.1 helix-turn-helix domain-containing protein Antitoxin
LZ023_RS39965 (LZ023_39790) 836900..837280 - 381 WP_268152297.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LZ023_RS39970 (LZ023_39795) 837960..838145 + 186 WP_268152299.1 hypothetical protein -
LZ023_RS39975 (LZ023_39800) 838333..838563 - 231 WP_268152301.1 chorismate mutase -
LZ023_RS39980 (LZ023_39805) 838693..838923 - 231 WP_268152303.1 hypothetical protein -
LZ023_RS39985 (LZ023_39810) 838991..839122 - 132 WP_268153169.1 hypothetical protein -
LZ023_RS39990 (LZ023_39815) 839266..840026 - 761 Protein_1061 AraC family transcriptional regulator -
LZ023_RS39995 (LZ023_39820) 840399..840892 + 494 Protein_1062 cysteine hydrolase family protein -
LZ023_RS40000 (LZ023_39825) 841058..841408 - 351 WP_034824206.1 DUF3147 family protein -
LZ023_RS40005 (LZ023_39830) 841418..841692 - 275 Protein_1064 metal/formaldehyde-sensitive transcriptional repressor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - clpV/tssH / clpV/tssH / vipB/tssC / vipB/tssC / vipA/tssB / iroN / cheD 1..952764 952764


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-122)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-95)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14014.39 Da        Isoelectric Point: 10.2477

>T237992 WP_268152297.1 NZ_CP093281:c837280-836900 [Pseudomonas sp. T1-3-2]
MAIYVLKPFDRNTKADGIDDGKLCIAALEVIAGRYEANLGGVYKKRIPLTKGKSSGARAVIAFKIDKHLFFVNGYAKSAV
KSTIREMTETELLLYKQVAKELFNLTTEQARRAIRAGKMREVQCDG

Download         Length: 381 bp

>T237992 NZ_LR883965:3283381-3283908 [Escherichia coli]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCGTT
AAATCTCTTTCTGACGACACATCTCGTTCGTCAACATCGCAACAAAATTCTGCGAGCGTATATCCTTTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATGCGGCAGTTGTTTTGAACGAGCCGCATTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTTACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTCGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATAAAAAAGCCCATACGTTTTATCAATCGCTGGGCTTTATCCCGTTGGTCGGAGAAAACGAAAATGCGTTA
TTTTTCCCAACCAAATCCATCGAACTGCTTTTCACACAGAGCGATTAA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12198.36 Da        Isoelectric Point: 9.0957

>AT237992 WP_058960952.1 NZ_CP093281:c836907-836581 [Pseudomonas sp. T1-3-2]
MVNYLKDLQEIAHDFNEIGVISDDLKEKIDSRVRLRELRATLPVLPMMSGQAIRELRERLGLSQAMLAACVGMSVATVIK
WEREEKKPNGAALRLLNIIDRKGLSVLQ

Download         Length: 327 bp

>AT237992 NZ_LR883965:3283108-3283374 [Escherichia coli]
ATGTCTGCTGTTAAAAAGCAGCGTATCGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGGGCTGCGGAAGTGATTGAACAGCATCGGCGGG
TGATCCTCAATGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCTGGTGAAAAGCTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References