Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RelE-HTH |
| Location | 836581..837280 | Replicon | plasmid p1 |
| Accession | NZ_CP093281 | ||
| Organism | Pseudomonas sp. T1-3-2 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | LZ023_RS39965 | Protein ID | WP_268152297.1 |
| Coordinates | 836900..837280 (-) | Length | 127 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | A0A9E8WGG5 |
| Locus tag | LZ023_RS39960 | Protein ID | WP_058960952.1 |
| Coordinates | 836581..836907 (-) | Length | 109 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LZ023_RS39935 (LZ023_39760) | 832409..833371 | + | 963 | WP_268152294.1 | AraC family transcriptional regulator | - |
| LZ023_RS39940 (LZ023_39765) | 833474..833975 | - | 502 | Protein_1051 | GNAT family N-acetyltransferase | - |
| LZ023_RS39945 (LZ023_39770) | 834031..834608 | + | 578 | Protein_1052 | helix-turn-helix transcriptional regulator | - |
| LZ023_RS39950 (LZ023_39775) | 834612..835548 | - | 937 | Protein_1053 | AraC family transcriptional regulator | - |
| LZ023_RS39955 (LZ023_39780) | 835657..836489 | + | 833 | Protein_1054 | oxidoreductase | - |
| LZ023_RS39960 (LZ023_39785) | 836581..836907 | - | 327 | WP_058960952.1 | helix-turn-helix domain-containing protein | Antitoxin |
| LZ023_RS39965 (LZ023_39790) | 836900..837280 | - | 381 | WP_268152297.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| LZ023_RS39970 (LZ023_39795) | 837960..838145 | + | 186 | WP_268152299.1 | hypothetical protein | - |
| LZ023_RS39975 (LZ023_39800) | 838333..838563 | - | 231 | WP_268152301.1 | chorismate mutase | - |
| LZ023_RS39980 (LZ023_39805) | 838693..838923 | - | 231 | WP_268152303.1 | hypothetical protein | - |
| LZ023_RS39985 (LZ023_39810) | 838991..839122 | - | 132 | WP_268153169.1 | hypothetical protein | - |
| LZ023_RS39990 (LZ023_39815) | 839266..840026 | - | 761 | Protein_1061 | AraC family transcriptional regulator | - |
| LZ023_RS39995 (LZ023_39820) | 840399..840892 | + | 494 | Protein_1062 | cysteine hydrolase family protein | - |
| LZ023_RS40000 (LZ023_39825) | 841058..841408 | - | 351 | WP_034824206.1 | DUF3147 family protein | - |
| LZ023_RS40005 (LZ023_39830) | 841418..841692 | - | 275 | Protein_1064 | metal/formaldehyde-sensitive transcriptional repressor | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | clpV/tssH / clpV/tssH / vipB/tssC / vipB/tssC / vipA/tssB / iroN / cheD | 1..952764 | 952764 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 127 a.a. Molecular weight: 14014.39 Da Isoelectric Point: 10.2477
>T237992 WP_268152297.1 NZ_CP093281:c837280-836900 [Pseudomonas sp. T1-3-2]
MAIYVLKPFDRNTKADGIDDGKLCIAALEVIAGRYEANLGGVYKKRIPLTKGKSSGARAVIAFKIDKHLFFVNGYAKSAV
KSTIREMTETELLLYKQVAKELFNLTTEQARRAIRAGKMREVQCDG
MAIYVLKPFDRNTKADGIDDGKLCIAALEVIAGRYEANLGGVYKKRIPLTKGKSSGARAVIAFKIDKHLFFVNGYAKSAV
KSTIREMTETELLLYKQVAKELFNLTTEQARRAIRAGKMREVQCDG
Download Length: 381 bp
>T237992 NZ_LR883965:3283381-3283908 [Escherichia coli]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCGTT
AAATCTCTTTCTGACGACACATCTCGTTCGTCAACATCGCAACAAAATTCTGCGAGCGTATATCCTTTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATGCGGCAGTTGTTTTGAACGAGCCGCATTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTTACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTCGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATAAAAAAGCCCATACGTTTTATCAATCGCTGGGCTTTATCCCGTTGGTCGGAGAAAACGAAAATGCGTTA
TTTTTCCCAACCAAATCCATCGAACTGCTTTTCACACAGAGCGATTAA
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCGTT
AAATCTCTTTCTGACGACACATCTCGTTCGTCAACATCGCAACAAAATTCTGCGAGCGTATATCCTTTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATGCGGCAGTTGTTTTGAACGAGCCGCATTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTTACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTCGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATAAAAAAGCCCATACGTTTTATCAATCGCTGGGCTTTATCCCGTTGGTCGGAGAAAACGAAAATGCGTTA
TTTTTCCCAACCAAATCCATCGAACTGCTTTTCACACAGAGCGATTAA
Antitoxin
Download Length: 109 a.a. Molecular weight: 12198.36 Da Isoelectric Point: 9.0957
>AT237992 WP_058960952.1 NZ_CP093281:c836907-836581 [Pseudomonas sp. T1-3-2]
MVNYLKDLQEIAHDFNEIGVISDDLKEKIDSRVRLRELRATLPVLPMMSGQAIRELRERLGLSQAMLAACVGMSVATVIK
WEREEKKPNGAALRLLNIIDRKGLSVLQ
MVNYLKDLQEIAHDFNEIGVISDDLKEKIDSRVRLRELRATLPVLPMMSGQAIRELRERLGLSQAMLAACVGMSVATVIK
WEREEKKPNGAALRLLNIIDRKGLSVLQ
Download Length: 327 bp
>AT237992 NZ_LR883965:3283108-3283374 [Escherichia coli]
ATGTCTGCTGTTAAAAAGCAGCGTATCGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGGGCTGCGGAAGTGATTGAACAGCATCGGCGGG
TGATCCTCAATGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCTGGTGAAAAGCTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA
ATGTCTGCTGTTAAAAAGCAGCGTATCGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGGGCTGCGGAAGTGATTGAACAGCATCGGCGGG
TGATCCTCAATGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCTGGTGAAAAGCTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|