Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 6615856..6616471 Replicon chromosome
Accession NZ_CP093280
Organism Pseudomonas sp. T1-3-2

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LZ023_RS29970 Protein ID WP_268144255.1
Coordinates 6616289..6616471 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LZ023_RS29965 Protein ID WP_176572362.1
Coordinates 6615856..6616257 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZ023_RS29950 (LZ023_29910) 6610963..6614343 + 3381 WP_268144250.1 ATP-binding protein -
LZ023_RS29955 (LZ023_29915) 6614340..6615530 + 1191 WP_268144251.1 DUF3322 domain-containing protein -
LZ023_RS29960 (LZ023_29920) 6615611..6615853 + 243 WP_268144253.1 hypothetical protein -
LZ023_RS29965 (LZ023_29925) 6615856..6616257 - 402 WP_176572362.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LZ023_RS29970 (LZ023_29930) 6616289..6616471 - 183 WP_268144255.1 type II toxin-antitoxin system HicA family toxin Toxin
LZ023_RS29975 (LZ023_29935) 6616586..6617389 - 804 WP_268144257.1 IclR family transcriptional regulator -
LZ023_RS29980 (LZ023_29940) 6617452..6618762 - 1311 WP_268144259.1 MFS transporter -
LZ023_RS29985 (LZ023_29945) 6618932..6620080 - 1149 WP_176570218.1 galactonate dehydratase -
LZ023_RS29990 (LZ023_29950) 6620114..6620734 - 621 WP_268144261.1 2-dehydro-3-deoxy-6-phosphogalactonate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6849.02 Da        Isoelectric Point: 11.3631

>T237991 WP_268144255.1 NZ_CP093280:c6616471-6616289 [Pseudomonas sp. T1-3-2]
MRSREMIRLIMQDGWFLVAVNGSHHQYKHPRKSGRVTIKHPDGDLPKGTINSILKQAGLK

Download         Length: 183 bp

>T237991 NZ_LR883965:3256034-3256309 [Escherichia coli]
ATGAGAACCAAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATATTTAAAACTCCTGTTCCTCAAGG
GATCAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGTAAGT
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14640.52 Da        Isoelectric Point: 4.5232

>AT237991 WP_176572362.1 NZ_CP093280:c6616257-6615856 [Pseudomonas sp. T1-3-2]
MKFAVVLHKDEDSEYGVIVPDVPGCFSAGTTVTEALESVEQALAFHFEGLVVDGEVLPNPKCIDEHMNNPDYAGGVWAVV
EIDITPYFGKSVRFNATLPEHLLDRIDQTVSRDRRYKSRSGFLAAAALRELSA

Download         Length: 402 bp

>AT237991 NZ_LR883965:3256306-3256665 [Escherichia coli]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCTGCAGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCTAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References