Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hicAB/- |
Location | 2134013..2134602 | Replicon | chromosome |
Accession | NZ_CP093280 | ||
Organism | Pseudomonas sp. T1-3-2 |
Toxin (Protein)
Gene name | hicA | Uniprot ID | - |
Locus tag | LZ023_RS09965 | Protein ID | WP_268148609.1 |
Coordinates | 2134013..2134219 (+) | Length | 69 a.a. |
Antitoxin (Protein)
Gene name | hicB | Uniprot ID | - |
Locus tag | LZ023_RS09970 | Protein ID | WP_268148611.1 |
Coordinates | 2134261..2134602 (+) | Length | 114 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LZ023_RS09935 (LZ023_09940) | 2129150..2130034 | + | 885 | WP_268148597.1 | acyl-CoA dehydrogenase family protein | - |
LZ023_RS09940 (LZ023_09945) | 2130157..2131248 | + | 1092 | WP_268148599.1 | serine hydrolase | - |
LZ023_RS09945 (LZ023_09950) | 2131245..2131544 | + | 300 | WP_268148601.1 | amidase | - |
LZ023_RS09950 (LZ023_09955) | 2131729..2132886 | + | 1158 | WP_268148603.1 | phosphatidylserine/phosphatidylglycerophosphate/ cardiolipin synthase family protein | - |
LZ023_RS09955 (LZ023_09960) | 2132988..2133569 | + | 582 | WP_268148605.1 | DJ-1/PfpI family protein | - |
LZ023_RS09960 (LZ023_09965) | 2133580..2133915 | + | 336 | WP_268148607.1 | ribbon-helix-helix domain-containing protein | - |
LZ023_RS09965 (LZ023_09970) | 2134013..2134219 | + | 207 | WP_268148609.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
LZ023_RS09970 (LZ023_09975) | 2134261..2134602 | + | 342 | WP_268148611.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
LZ023_RS09975 (LZ023_09980) | 2134812..2136335 | - | 1524 | WP_268148613.1 | fumarate hydratase | - |
LZ023_RS09980 (LZ023_09985) | 2136672..2137778 | + | 1107 | WP_268151355.1 | GGDEF domain-containing protein | - |
LZ023_RS09985 (LZ023_09990) | 2137771..2138727 | + | 957 | WP_268148615.1 | iron-sulfur-binding ferredoxin reductase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 69 a.a. Molecular weight: 7653.91 Da Isoelectric Point: 10.0490
>T237989 WP_268148609.1 NZ_CP093280:2134013-2134219 [Pseudomonas sp. T1-3-2]
MSKQEKLLAKLLNKQGSFTWQELVTLLRGLGYDQVEGVGSRVKFDNGNPMAMINLHKPHPGNELKAYL
MSKQEKLLAKLLNKQGSFTWQELVTLLRGLGYDQVEGVGSRVKFDNGNPMAMINLHKPHPGNELKAYL
Download Length: 207 bp
>T237989 NZ_LR883965:3180930-3181037 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGTATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGTATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA
Antitoxin
Download Length: 114 a.a. Molecular weight: 12485.04 Da Isoelectric Point: 5.5421
>AT237989 WP_268148611.1 NZ_CP093280:2134261-2134602 [Pseudomonas sp. T1-3-2]
MSKLLQHRGYFGSIEASPEDNCLFGKLQFIRALVSYEGETVAELSQAFRDAVDDYLATCDSLNQNPEIPCKGSFNVRVGH
DLHLAATVAALKQSISLNDLTRQALREYLGNHA
MSKLLQHRGYFGSIEASPEDNCLFGKLQFIRALVSYEGETVAELSQAFRDAVDDYLATCDSLNQNPEIPCKGSFNVRVGH
DLHLAATVAALKQSISLNDLTRQALREYLGNHA
Download Length: 342 bp
>AT237989 NZ_LR883965:c3180872-3180816 [Escherichia coli]
CAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT
CAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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