Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2134013..2134602 Replicon chromosome
Accession NZ_CP093280
Organism Pseudomonas sp. T1-3-2

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LZ023_RS09965 Protein ID WP_268148609.1
Coordinates 2134013..2134219 (+) Length 69 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LZ023_RS09970 Protein ID WP_268148611.1
Coordinates 2134261..2134602 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZ023_RS09935 (LZ023_09940) 2129150..2130034 + 885 WP_268148597.1 acyl-CoA dehydrogenase family protein -
LZ023_RS09940 (LZ023_09945) 2130157..2131248 + 1092 WP_268148599.1 serine hydrolase -
LZ023_RS09945 (LZ023_09950) 2131245..2131544 + 300 WP_268148601.1 amidase -
LZ023_RS09950 (LZ023_09955) 2131729..2132886 + 1158 WP_268148603.1 phosphatidylserine/phosphatidylglycerophosphate/ cardiolipin synthase family protein -
LZ023_RS09955 (LZ023_09960) 2132988..2133569 + 582 WP_268148605.1 DJ-1/PfpI family protein -
LZ023_RS09960 (LZ023_09965) 2133580..2133915 + 336 WP_268148607.1 ribbon-helix-helix domain-containing protein -
LZ023_RS09965 (LZ023_09970) 2134013..2134219 + 207 WP_268148609.1 type II toxin-antitoxin system HicA family toxin Toxin
LZ023_RS09970 (LZ023_09975) 2134261..2134602 + 342 WP_268148611.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LZ023_RS09975 (LZ023_09980) 2134812..2136335 - 1524 WP_268148613.1 fumarate hydratase -
LZ023_RS09980 (LZ023_09985) 2136672..2137778 + 1107 WP_268151355.1 GGDEF domain-containing protein -
LZ023_RS09985 (LZ023_09990) 2137771..2138727 + 957 WP_268148615.1 iron-sulfur-binding ferredoxin reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-68)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 7653.91 Da        Isoelectric Point: 10.0490

>T237989 WP_268148609.1 NZ_CP093280:2134013-2134219 [Pseudomonas sp. T1-3-2]
MSKQEKLLAKLLNKQGSFTWQELVTLLRGLGYDQVEGVGSRVKFDNGNPMAMINLHKPHPGNELKAYL

Download         Length: 207 bp

>T237989 NZ_LR883965:3180930-3181037 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGTATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12485.04 Da        Isoelectric Point: 5.5421

>AT237989 WP_268148611.1 NZ_CP093280:2134261-2134602 [Pseudomonas sp. T1-3-2]
MSKLLQHRGYFGSIEASPEDNCLFGKLQFIRALVSYEGETVAELSQAFRDAVDDYLATCDSLNQNPEIPCKGSFNVRVGH
DLHLAATVAALKQSISLNDLTRQALREYLGNHA

Download         Length: 342 bp

>AT237989 NZ_LR883965:c3180872-3180816 [Escherichia coli]
CAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References