Detailed information of TA system TA237988

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PP_4151-4152/excise(antitoxin)
• Location: 1934964..1936003
• Replicon: chromosome
• Accession: NZ_CP093280
• Organism: Pseudomonas sp. T1-3-2

Toxin (Protein)

• Gene name: PP_4152
• Uniprot ID: -
• Locus tag: LZ023_RS09040
• Protein ID: WP_268148326.1
• Coordinates: 1935428..1936003 (+)
• Length: 192 a.a.

Antitoxin (Protein)

• Gene name: PP_4151
• Uniprot ID: -
• Locus tag: LZ023_RS09035
• Protein ID: WP_268148324.1
• Coordinates: 1934964..1935428 (+)
• Length: 155 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LZ023_RS09005 (LZ023_09010)	1930377..1931597	-	1221	WP_268148318.1	type II secretion system F family protein	-
LZ023_RS09010 (LZ023_09015)	1931601..1933298	-	1698	WP_268148320.1	type IV-A pilus assembly ATPase PilB	-
LZ023_RS09015 (LZ023_09020)	1933525..1933941	+	417	WP_268148322.1	pilin	-
LZ023_RS09020 (LZ023_09025)	1934012..1934125	+	114	Protein_1763	prepilin-type N-terminal cleavage/methylation domain-containing protein	-
LZ023_RS09025 (LZ023_09030)	1934126..1934425	+	300	WP_268151337.1	pilin	-
LZ023_RS09035 (LZ023_09040)	1934964..1935428	+	465	WP_268148324.1	helix-turn-helix domain-containing protein	Antitoxin
LZ023_RS09040 (LZ023_09045)	1935428..1936003	+	576	WP_268148326.1	PIN domain-containing protein	Toxin
LZ023_RS09045 (LZ023_09050)	1936320..1937093	+	774	WP_268148328.1	EAL domain-containing protein	-
LZ023_RS09050 (LZ023_09055)	1937221..1937484	-	264	WP_268148330.1	hypothetical protein	-
LZ023_RS09055 (LZ023_09060)	1937528..1938376	-	849	WP_268148332.1	carboxylating nicotinate-nucleotide diphosphorylase	-
LZ023_RS09060 (LZ023_09065)	1938743..1940962	+	2220	WP_268148334.1	DUF1631 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (8-115)

Antitoxin

• Helix-turn-helix domain, group 17 (84-131)

Sequences

Toxin

Protein

• Length: 192 a.a.
• Molecular weight: 21906.27 Da
• Isoelectric Point: 6.1427

>T237988 WP_268148326.1 NZ_CP093280:1935428-1936003 [Pseudomonas sp. T1-3-2]
MRHSPFTVIYDACVLYPAPLRDLLMHLALTGVYRARWSGQIHDEWTRNVLKNRSDLTKAQLHRTVEAMNRAVPDCLVSDY
EPLMPGLDLPDEDDRHVLAAAIKCGATVIVTYNLKDFPAEILKRFEIEALHPDVFLSDVWDLDQAAVLEAVQKQRASLKN
PRYTARELLDTLLTQRLPEIVKHLSSYELFI

Nucleotide

• Length: 576 bp

>T237988 NZ_LR883965:3180447-3180554 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAG

Antitoxin

Protein

• Length: 155 a.a.
• Molecular weight: 16951.30 Da
• Isoelectric Point: 5.2576

>AT237988 WP_268148324.1 NZ_CP093280:1934964-1935428 [Pseudomonas sp. T1-3-2]
MTTADLARSVLPDERAIAAATESSRQIAAFVSTKLDTQRIELIDEAQQRQAVELPTFALRLLGEILSELALGNTVKVVPI
HAELTTQEGADMLNVSRPHLVKLLDDGQIPHTKTGSHRRIKFTDIMAYKADRDRASQAAMEELAAQAQELNMGY

Nucleotide

• Length: 465 bp

>AT237988 NZ_LR883965:c3180399-3180333 [Escherichia coli]
GGTCTAGATGCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT