Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/HTH_IclR(antitoxin) |
| Location | 1071033..1072726 | Replicon | chromosome |
| Accession | NZ_CP093280 | ||
| Organism | Pseudomonas sp. T1-3-2 | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | - |
| Locus tag | LZ023_RS04860 | Protein ID | WP_268146986.1 |
| Coordinates | 1071854..1072726 (-) | Length | 291 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | - |
| Locus tag | LZ023_RS04855 | Protein ID | WP_268146984.1 |
| Coordinates | 1071033..1071857 (-) | Length | 275 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LZ023_RS04835 (LZ023_04835) | 1066239..1067735 | - | 1497 | WP_268146975.1 | aldehyde dehydrogenase | - |
| LZ023_RS04840 (LZ023_04840) | 1067745..1068548 | - | 804 | WP_268146977.1 | aspartate dehydrogenase | - |
| LZ023_RS04845 (LZ023_04845) | 1068559..1070241 | - | 1683 | WP_268146979.1 | thiamine pyrophosphate-binding protein | - |
| LZ023_RS04850 (LZ023_04850) | 1070234..1071031 | - | 798 | WP_268146981.1 | SDR family oxidoreductase | - |
| LZ023_RS04855 (LZ023_04855) | 1071033..1071857 | - | 825 | WP_268146984.1 | IclR family transcriptional regulator | Antitoxin |
| LZ023_RS04860 (LZ023_04860) | 1071854..1072726 | - | 873 | WP_268146986.1 | alpha/beta hydrolase | Toxin |
| LZ023_RS04865 (LZ023_04865) | 1072733..1073272 | - | 540 | WP_268146988.1 | cupin domain-containing protein | - |
| LZ023_RS04870 (LZ023_04870) | 1073286..1074050 | - | 765 | WP_268151270.1 | SDR family oxidoreductase | - |
| LZ023_RS04875 (LZ023_04875) | 1074050..1074826 | - | 777 | WP_268146990.1 | ABC transporter permease | - |
| LZ023_RS04880 (LZ023_04880) | 1074856..1075245 | - | 390 | WP_268151272.1 | ABC transporter substrate-binding protein | - |
| LZ023_RS04885 (LZ023_04885) | 1075267..1075905 | - | 639 | Protein_951 | ABC transporter permease | - |
| LZ023_RS04890 (LZ023_04890) | 1075935..1076324 | - | 390 | WP_268151272.1 | ABC transporter substrate-binding protein | - |
| LZ023_RS04895 (LZ023_04895) | 1076346..1076984 | - | 639 | Protein_953 | ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | algB | 836547..1225028 | 388481 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 291 a.a. Molecular weight: 31035.48 Da Isoelectric Point: 7.4617
>T237987 WP_268146986.1 NZ_CP093280:c1072726-1071854 [Pseudomonas sp. T1-3-2]
MHATESLDPCTELQTLLANRFAQRLLDVAGDQQAIREAGRGAAIVLLHGIGSGAGSWLEVALQLGQHARVVAWDAPGYGD
STPLRPAAPRAEDYAERLLHTLDALTIERCVLVGHSLGAITAAAFSRLYPQRVSRLVLLSPARGYGDPAREVQRQQVRGQ
RLTTLEQLGVAQMAAQRSSAMLSPRPTAKALAWVRWNMARLNQQGYRQAIELLCGDDLLRHAPLPVPCEVHCGEADAITA
PETCLTLAKALGASFNLIADAGHASPIEQPHVVAGRLAHALKESLTGSAQ
MHATESLDPCTELQTLLANRFAQRLLDVAGDQQAIREAGRGAAIVLLHGIGSGAGSWLEVALQLGQHARVVAWDAPGYGD
STPLRPAAPRAEDYAERLLHTLDALTIERCVLVGHSLGAITAAAFSRLYPQRVSRLVLLSPARGYGDPAREVQRQQVRGQ
RLTTLEQLGVAQMAAQRSSAMLSPRPTAKALAWVRWNMARLNQQGYRQAIELLCGDDLLRHAPLPVPCEVHCGEADAITA
PETCLTLAKALGASFNLIADAGHASPIEQPHVVAGRLAHALKESLTGSAQ
Download Length: 873 bp
>T237987 NZ_LR883965:c2782884-2782573 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTTTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTATTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTTTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTATTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA
Antitoxin
Download Length: 275 a.a. Molecular weight: 30480.92 Da Isoelectric Point: 6.4979
>AT237987 WP_268146984.1 NZ_CP093280:c1071857-1071033 [Pseudomonas sp. T1-3-2]
MTDTDLTKDAQDKYIVPGLERGLLLLCEFSRQNRTLTAPELARRLELPRSTIFRLLTTLETMGFVTRSGNEYRLGMSVLR
LGFEYLASLELTELGQPLLARLCDKLNYPSNLVVRDGRSIVYVAKVSPPSVFSSAVNVGTRLPAHATVLGRILLEDLSLA
ELRELYPEEHLEQHSLCTPKTVLELFDLVQGDRQRGYVSGEGFFESAISTVAAPVRDHSGRIVAALGVTIPTTQIGHVNF
EETLAQVRRNADELSRLLNYTPSHGSRVTALMRD
MTDTDLTKDAQDKYIVPGLERGLLLLCEFSRQNRTLTAPELARRLELPRSTIFRLLTTLETMGFVTRSGNEYRLGMSVLR
LGFEYLASLELTELGQPLLARLCDKLNYPSNLVVRDGRSIVYVAKVSPPSVFSSAVNVGTRLPAHATVLGRILLEDLSLA
ELRELYPEEHLEQHSLCTPKTVLELFDLVQGDRQRGYVSGEGFFESAISTVAAPVRDHSGRIVAALGVTIPTTQIGHVNF
EETLAQVRRNADELSRLLNYTPSHGSRVTALMRD
Download Length: 825 bp
>AT237987 NZ_LR883965:c2782572-2782282 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
GCGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCTGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
GCGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCTGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|