Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | pmenTA/darT(toxin) |
| Location | 596975..598698 | Replicon | chromosome |
| Accession | NZ_CP093280 | ||
| Organism | Pseudomonas sp. T1-3-2 | ||
Toxin (Protein)
| Gene name | pmenT | Uniprot ID | - |
| Locus tag | LZ023_RS02600 | Protein ID | WP_268146196.1 |
| Coordinates | 596975..597616 (+) | Length | 214 a.a. |
Antitoxin (Protein)
| Gene name | pmenA | Uniprot ID | - |
| Locus tag | LZ023_RS02605 | Protein ID | WP_268146198.1 |
| Coordinates | 597616..598698 (+) | Length | 361 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LZ023_RS02565 (LZ023_02565) | 592404..592613 | + | 210 | WP_268146182.1 | KTSC domain-containing protein | - |
| LZ023_RS02570 (LZ023_02570) | 593146..593385 | - | 240 | WP_268146184.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
| LZ023_RS02575 (LZ023_02575) | 593710..594021 | + | 312 | WP_268146186.1 | hypothetical protein | - |
| LZ023_RS02580 (LZ023_02580) | 594577..594966 | - | 390 | WP_268146188.1 | hypothetical protein | - |
| LZ023_RS02585 (LZ023_02585) | 595193..595555 | - | 363 | WP_268146190.1 | hypothetical protein | - |
| LZ023_RS02590 (LZ023_02590) | 595588..596166 | - | 579 | WP_268146192.1 | hypothetical protein | - |
| LZ023_RS02595 (LZ023_02595) | 596397..596978 | + | 582 | WP_268146194.1 | DarT ssDNA thymidine ADP-ribosyltransferase family protein | - |
| LZ023_RS02600 (LZ023_02600) | 596975..597616 | + | 642 | WP_268146196.1 | DUF4433 domain-containing protein | Toxin |
| LZ023_RS02605 (LZ023_02605) | 597616..598698 | + | 1083 | WP_268146198.1 | macro domain-containing protein | Antitoxin |
| LZ023_RS02610 (LZ023_02610) | 598737..599618 | - | 882 | Protein_504 | sensor domain-containing diguanylate cyclase | - |
| LZ023_RS02615 (LZ023_02615) | 599879..600298 | + | 420 | WP_268146200.1 | PH domain-containing protein | - |
| LZ023_RS02620 (LZ023_02620) | 600417..600860 | + | 444 | WP_268146202.1 | DUF3828 domain-containing protein | - |
| LZ023_RS02625 (LZ023_02625) | 600935..601522 | - | 588 | WP_268146204.1 | hypothetical protein | - |
| LZ023_RS02630 (LZ023_02630) | 601690..602595 | + | 906 | WP_268146206.1 | glycosyltransferase family 2 protein | - |
| LZ023_RS02635 (LZ023_02635) | 602615..603244 | + | 630 | WP_268146208.1 | CatB-related O-acetyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 586071..598698 | 12627 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 214 a.a. Molecular weight: 24575.37 Da Isoelectric Point: 7.8976
>T237986 WP_268146196.1 NZ_CP093280:596975-597616 [Pseudomonas sp. T1-3-2]
MIYGRLNPDKALIWRVVHRDNLPWILDHGLHCENSERKAPAYVNIGNAELIDKRRTRCVPVHPGGVLSDYVPFYFTPFSV
MMKNIHSGRSVQKRGNEEIVVLVSSLHLISSLGLPFVFTNAHAYPDWTSYYTDLSSLDQIDWVILQRRDFKRDPDDPKKM
ERYQAEALIHQHLPMAGLLGIMCYTEAMKTSIELELTARGLTLPVHVRPGWYF
MIYGRLNPDKALIWRVVHRDNLPWILDHGLHCENSERKAPAYVNIGNAELIDKRRTRCVPVHPGGVLSDYVPFYFTPFSV
MMKNIHSGRSVQKRGNEEIVVLVSSLHLISSLGLPFVFTNAHAYPDWTSYYTDLSSLDQIDWVILQRRDFKRDPDDPKKM
ERYQAEALIHQHLPMAGLLGIMCYTEAMKTSIELELTARGLTLPVHVRPGWYF
Download Length: 642 bp
>T237986 NZ_LR883965:c2505892-2505719 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG
Antitoxin
Download Length: 361 a.a. Molecular weight: 40025.21 Da Isoelectric Point: 6.0030
>AT237986 WP_268146198.1 NZ_CP093280:597616-598698 [Pseudomonas sp. T1-3-2]
MIRFTQGNLLEAKAEALVNTVNTVGVMGKGIALMFKERFAQNYRLYAAACKAGAVETGKVFVTDVAELDGPRWLVNFPTK
RHWRSPSQMAWITEGLQDLRRFILANDVKSIAIPPLGAGNGGLEWADVRKEIVAAMDGLEADILVFEPTSRYLNVAKRSG
VEKLTPARALIAELVRRYWVLGMECSLLEIQKLAWFLERMIERLPGTENPLDLKFVAHIYGPYANRLEHLLDNLDGSYLH
CDKRISDAGITDVIWFDEERKNFLQAYLKTEGKAFSEALEATARLIDGFESPFGMELLATVDWLISQEGIAPSVPHVLDA
LGKWPGGTGAAARKVKIFDEQAVGIALARLDDSPLRPTCH
MIRFTQGNLLEAKAEALVNTVNTVGVMGKGIALMFKERFAQNYRLYAAACKAGAVETGKVFVTDVAELDGPRWLVNFPTK
RHWRSPSQMAWITEGLQDLRRFILANDVKSIAIPPLGAGNGGLEWADVRKEIVAAMDGLEADILVFEPTSRYLNVAKRSG
VEKLTPARALIAELVRRYWVLGMECSLLEIQKLAWFLERMIERLPGTENPLDLKFVAHIYGPYANRLEHLLDNLDGSYLH
CDKRISDAGITDVIWFDEERKNFLQAYLKTEGKAFSEALEATARLIDGFESPFGMELLATVDWLISQEGIAPSVPHVLDA
LGKWPGGTGAAARKVKIFDEQAVGIALARLDDSPLRPTCH
Download Length: 1083 bp
>AT237986 NZ_LR883965:c2506216-2505920 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|