Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4630539..4631158 Replicon chromosome
Accession NZ_CP093276
Organism Raoultella sp. HC6

Toxin (Protein)


Gene name Hha Uniprot ID A0A8B4Z516
Locus tag MMW58_RS22410 Protein ID WP_041144355.1
Coordinates 4630940..4631158 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A8B4Z4D4
Locus tag MMW58_RS22405 Protein ID WP_041144356.1
Coordinates 4630539..4630913 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MMW58_RS22395 4625701..4626882 + 1182 WP_133596460.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
MMW58_RS22400 4626917..4630063 + 3147 WP_133596458.1 multidrug efflux RND transporter permease subunit AcrB -
MMW58_RS22405 4630539..4630913 + 375 WP_041144356.1 Hha toxicity modulator TomB Antitoxin
MMW58_RS22410 4630940..4631158 + 219 WP_041144355.1 HHA domain-containing protein Toxin
MMW58_RS22415 4631308..4631874 + 567 WP_241722136.1 maltose O-acetyltransferase -
MMW58_RS22420 4631973..4632440 + 468 WP_133596456.1 YlaC family protein -
MMW58_RS22425 4632412..4633869 - 1458 WP_241722137.1 PLP-dependent aminotransferase family protein -
MMW58_RS22430 4633971..4634681 + 711 WP_241722138.1 GNAT family protein -
MMW58_RS22435 4634678..4634818 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
MMW58_RS22440 4634818..4635081 - 264 WP_133596451.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8580.94 Da        Isoelectric Point: 7.9907

>T237981 WP_041144355.1 NZ_CP093276:4630940-4631158 [Raoultella sp. HC6]
MSGEPLTKTDYLMRLRRCQTIDTLERVIEKNKYELPDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T237981 NZ_LR883965:c676327-676151 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14397.16 Da        Isoelectric Point: 4.8886

>AT237981 WP_041144356.1 NZ_CP093276:4630539-4630913 [Raoultella sp. HC6]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIDHIATFALNYKIKYAEDNKLIAQLDEYL
DDTFMLFSSYGINSVDLQKWRKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT237981 NZ_LR883965:c676105-675689 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTGACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4Z516

Antitoxin

Source ID Structure
AlphaFold DB A0A8B4Z4D4

References