Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 3073788..3075376 Replicon chromosome
Accession NZ_CP093276
Organism Raoultella sp. HC6

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag MMW58_RS14980 Protein ID WP_241721502.1
Coordinates 3073788..3075107 (-) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag MMW58_RS14985 Protein ID WP_115193957.1
Coordinates 3075107..3075376 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MMW58_RS14955 3069309..3070595 + 1287 WP_166646188.1 glycoside hydrolase family 10 protein -
MMW58_RS14960 3070786..3071358 + 573 WP_041145490.1 peroxiredoxin -
MMW58_RS14965 3071374..3072606 + 1233 WP_241721501.1 thioredoxin family protein -
MMW58_RS14970 3072621..3073175 + 555 WP_159237755.1 sigma-70 family RNA polymerase sigma factor -
MMW58_RS14975 3073162..3073791 + 630 WP_159237754.1 NrsF family protein -
MMW58_RS14980 3073788..3075107 - 1320 WP_241721502.1 type II toxin-antitoxin system HipA family toxin Toxin
MMW58_RS14985 3075107..3075376 - 270 WP_115193957.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
MMW58_RS14990 3075572..3076132 - 561 WP_241721503.1 RNA polymerase sigma factor -
MMW58_RS14995 3076138..3076572 - 435 WP_241721504.1 hypothetical protein -
MMW58_RS15000 3076712..3077668 - 957 WP_241721505.1 hypothetical protein -
MMW58_RS15005 3077779..3079017 - 1239 WP_241721506.1 sensor domain-containing diguanylate cyclase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-401)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-67)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 48548.70 Da        Isoelectric Point: 6.8432

>T237980 WP_241721502.1 NZ_CP093276:c3075107-3073788 [Raoultella sp. HC6]
MATLVTWMNNERVGELVKLANGAHQFRYDPRWLQNPRARPLSLSLPLQFGNITSDAVFNYFDNLLPDSPLVRDRIVKRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPEGAAPATGALTWEALDDARLDALLTAYRADIPLGMINGQEAFRISVAGAQEKTAL
LKMDDRWCIPTATTPTTHIIKLPIGEIRQPDAVLDLSESVDNEYLCLALARALGFAVPDAEIITTRSIRALAVERFDRRW
AQENTRLLRLPQEDLCQAFGIPSSMKYESDGGPGIASIMAFLLGSSEALRDRADFMKFIVFQWLIGATDGHAKNFSIFLQ
PGGSYRLTPFYDIISAFPVLGGAGLHISDLKLSMSLKASKGRKTEIQTIYPRHFLATAKEVGFAQQQMLEILRYFADNLP
RAVDAVSASLPEDFSPTVYQAIISHTLRNHARLQSGLAG

Download         Length: 1320 bp

>T237980 NZ_CP093276:c3075107-3073788 [Raoultella sp. HC6]
ATGGCGACGCTCGTGACGTGGATGAACAATGAACGCGTCGGGGAGCTGGTCAAGCTGGCCAACGGCGCGCATCAGTTCCG
CTACGACCCGCGCTGGCTGCAAAACCCGCGCGCCCGCCCGCTCTCCCTGTCGCTGCCGCTGCAGTTCGGCAACATCACTT
CGGATGCGGTGTTTAACTACTTCGACAACCTGCTGCCCGACAGTCCGCTGGTGCGTGACCGCATTGTTAAGCGCTATCAG
GCCCGCTCGAAGCAGCCCTTCGATCTGCTGGCCGAGGTGGGGCGCGACAGCGTCGGGGCGGTCACTCTTCTGCCCGAGGG
CGCCGCTCCGGCCACCGGTGCCCTGACCTGGGAAGCGCTCGACGACGCCCGGCTTGACGCGCTGCTGACGGCCTACCGTG
CGGATATTCCGCTGGGCATGATTAACGGCCAGGAGGCGTTCAGAATATCGGTCGCCGGTGCCCAGGAGAAAACGGCGCTG
CTGAAGATGGACGACCGCTGGTGCATACCGACGGCAACAACGCCGACGACGCATATTATTAAGCTGCCGATCGGCGAGAT
ACGGCAGCCGGACGCGGTGCTGGATCTCAGCGAAAGCGTCGATAACGAATATCTCTGTCTGGCCCTCGCGCGGGCGCTGG
GCTTTGCCGTGCCGGATGCGGAAATTATCACCACCCGCAGCATCCGGGCGCTGGCCGTTGAGCGCTTTGACCGCCGCTGG
GCGCAGGAAAACACGCGGCTGCTGCGCCTGCCGCAGGAGGATCTATGCCAGGCGTTCGGCATTCCTTCCTCAATGAAGTA
CGAGTCGGACGGCGGGCCGGGGATCGCCAGCATCATGGCGTTTCTGCTCGGCTCCAGCGAGGCGCTGAGGGATCGCGCCG
ATTTTATGAAGTTCATCGTTTTTCAATGGCTGATCGGCGCCACCGACGGTCATGCGAAGAATTTTTCCATTTTCCTGCAG
CCCGGCGGCAGCTACCGTCTGACGCCGTTCTACGACATTATCTCGGCGTTTCCTGTGCTGGGGGGCGCGGGTTTGCATAT
CAGCGACCTTAAGCTGTCGATGAGCCTGAAAGCGTCGAAAGGGCGGAAAACGGAGATTCAGACCATCTATCCGCGCCATT
TCCTCGCCACGGCAAAAGAGGTGGGATTTGCGCAGCAGCAGATGCTGGAGATCCTGCGCTATTTTGCCGATAACCTGCCG
CGGGCGGTCGATGCGGTCAGCGCCTCGCTGCCGGAGGATTTTTCCCCGACGGTTTACCAGGCCATTATCTCGCATACCCT
CAGAAACCATGCCCGCCTGCAGAGCGGGCTAGCGGGTTAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10137.54 Da        Isoelectric Point: 8.0441

>AT237980 WP_115193957.1 NZ_CP093276:c3075376-3075107 [Raoultella sp. HC6]
ITPPTIYSPAQLANHIKLVRQKNQWTQSDLARRIGIKQATISNFENHPDKTTLTTLFKILQSLEMTMVVCEKGATSGPEQ
QDSQRDLEW

Download         Length: 270 bp

>AT237980 NZ_CP093276:c3075376-3075107 [Raoultella sp. HC6]
ATAACGCCCCCGACGATCTACAGCCCGGCCCAGCTGGCAAACCATATCAAGCTGGTGCGGCAAAAAAACCAGTGGACGCA
AAGCGATCTGGCCCGCCGGATAGGTATTAAGCAGGCGACGATCTCGAACTTCGAAAACCATCCGGACAAAACCACCCTCA
CCACGCTGTTCAAGATTTTACAATCTCTTGAAATGACGATGGTGGTGTGCGAAAAGGGCGCGACGTCGGGTCCTGAGCAA
CAGGATAGCCAACGGGATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References