Detailed information of TA system TA023798

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 4329236..4330020
• Replicon: chromosome
• Accession: NC_012669
• Organism: Beutenbergia cavernae DSM 12333

Toxin (Protein)

• Gene name: tacT
• Uniprot ID: C5C4M5
• Locus tag: BCAV_RS19680
• Protein ID: WP_015884386.1
• Coordinates: 4329236..4329742 (-)
• Length: 169 a.a.

Antitoxin (Protein)

• Gene name: tacA
• Uniprot ID: C5C4M6
• Locus tag: BCAV_RS19685
• Protein ID: WP_015884387.1
• Coordinates: 4329739..4330020 (-)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BCAV_RS19670	4325071..4325790	+	720	WP_015884384.1	alpha/beta hydrolase	-
BCAV_RS19675	4325841..4329134	-	3294	WP_015884385.1	type I restriction endonuclease subunit R	-
BCAV_RS19680	4329236..4329742	-	507	WP_015884386.1	GNAT family N-acetyltransferase	Toxin
BCAV_RS19685	4329739..4330020	-	282	WP_015884387.1	DUF1778 domain-containing protein	Antitoxin
BCAV_RS19690	4330100..4331368	-	1269	WP_015884388.1	hypothetical protein	-
BCAV_RS19700	4331738..4332139	-	402	WP_043347595.1	helix-turn-helix domain-containing protein	-
BCAV_RS19705	4332123..4332635	-	513	WP_015884390.1	hypothetical protein	-
BCAV_RS19710	4332675..4333409	-	735	WP_015884391.1	hypothetical protein	-
BCAV_RS21885	4333406..4334623	-	1218	WP_015884392.1	restriction endonuclease subunit S	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (49-144)

Antitoxin

• Vibrio phage ICP1, Orf50 (10-85)

Sequences

Toxin

Protein

• Length: 169 a.a.
• Molecular weight: 18481.19 Da
• Isoelectric Point: 7.9529

>T23798 WP_015884386.1 NC_012669:c4329742-4329236 [Beutenbergia cavernae DSM 12333]
VSVFFAPEPLADHHRVDEFTCGVSSLDDWLKRRALSNATSGASQTFVVADPSDAVVAYYSLSTGSIMRGDLPRGRRHGTP
QPVPVLLIGRFAVDVAHHGAGIGRSLLQDALQRCLRLTSQIGFMFVLVHPVNDAADGFWRKYGFVDAPTEQPMLLLPLDQ
LRRMRLPS

Nucleotide

• Length: 507 bp

>T23798 NC_012669:c4329742-4329236 [Beutenbergia cavernae DSM 12333]
GTGAGCGTCTTCTTCGCCCCGGAACCGCTCGCGGATCACCACCGCGTCGATGAGTTCACCTGCGGTGTCTCCTCCCTCGA
CGACTGGCTGAAGCGCCGAGCGCTCTCGAATGCGACGAGCGGGGCGTCCCAGACGTTCGTCGTCGCTGATCCATCGGACG
CGGTCGTGGCGTACTACTCGCTCTCCACGGGCTCCATCATGCGCGGCGACCTGCCGCGCGGTCGTCGACACGGCACCCCC
CAGCCGGTCCCAGTCCTGCTCATCGGTCGCTTCGCAGTCGACGTCGCGCACCATGGTGCGGGGATCGGGCGATCCCTGCT
CCAGGACGCGCTCCAGCGATGCCTTCGGCTGACGAGTCAGATCGGTTTCATGTTCGTCCTGGTGCATCCCGTGAATGACG
CCGCCGACGGGTTCTGGCGCAAGTACGGGTTCGTCGACGCGCCTACCGAGCAACCCATGCTCTTGCTTCCCCTCGACCAA
CTCAGGCGGATGCGTCTGCCGTCGTAA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10321.85 Da
• Isoelectric Point: 5.8651

>AT23798 WP_015884387.1 NC_012669:c4330020-4329739 [Beutenbergia cavernae DSM 12333]
MATKTPKAERIALRVTHRQKETIAAAAELLGRSVTDFAVQVAVEKADEVIAAQRTFQVPADKWAEFERLMKDPIEPNPGL
VDLFSEPSVFTAR

Nucleotide

• Length: 282 bp

>AT23798 NC_012669:c4330020-4329739 [Beutenbergia cavernae DSM 12333]
ATGGCAACCAAGACCCCGAAGGCCGAGCGGATCGCGCTTCGCGTCACGCACCGGCAGAAGGAGACGATCGCCGCAGCCGC
CGAGCTGCTCGGCCGATCCGTCACCGACTTCGCCGTCCAGGTTGCGGTCGAGAAGGCTGATGAGGTGATCGCCGCCCAAC
GCACCTTCCAGGTCCCCGCCGACAAGTGGGCCGAGTTCGAGCGTTTGATGAAGGACCCCATCGAGCCGAACCCCGGTCTC
GTAGACCTCTTCTCCGAGCCGTCCGTGTTCACCGCTCGGTGA

Structures

Toxin

• AlphaFold DB: C5C4M5

Antitoxin

• AlphaFold DB: C5C4M6