Detailed information of TA system TA237979

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 3058197..3059098
• Replicon: chromosome
• Accession: NZ_CP093276
• Organism: Raoultella sp. HC6

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: MMW58_RS14900
• Protein ID: WP_133599790.1
• Coordinates: 3058637..3059098 (+)
• Length: 154 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A8B4Z103
• Locus tag: MMW58_RS14895
• Protein ID: WP_045855354.1
• Coordinates: 3058197..3058640 (+)
• Length: 148 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MMW58_RS14875	3054859..3055734	-	876	WP_241721495.1	AraC family transcriptional regulator	-
MMW58_RS14880	3055893..3056648	+	756	WP_241721496.1	SDR family oxidoreductase	-
MMW58_RS14885	3056678..3057271	-	594	WP_241721497.1	TetR/AcrR family transcriptional regulator	-
MMW58_RS14890	3057345..3058058	+	714	WP_133599789.1	SDR family oxidoreductase	-
MMW58_RS14895	3058197..3058640	+	444	WP_045855354.1	DUF2384 domain-containing protein	Antitoxin
MMW58_RS14900	3058637..3059098	+	462	WP_133599790.1	RES family NAD+ phosphorylase	Toxin
MMW58_RS14905	3059156..3059401	-	246	WP_133599791.1	DUF2543 family protein	-
MMW58_RS14910	3059576..3060067	-	492	WP_159237760.1	GNAT family N-acetyltransferase	-
MMW58_RS14915	3060163..3060840	-	678	WP_241721498.1	transporter substrate-binding domain-containing protein	-
MMW58_RS14920	3061215..3062159	+	945	WP_241721499.1	DHH family phosphoesterase	-
MMW58_RS14925	3062200..3063483	-	1284	WP_133599795.1	citrate synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-147)

Antitoxin

• Antitoxin Xre-like, helix-turn-helix domain (32-89)

Sequences

Toxin

Protein

• Length: 154 a.a.
• Molecular weight: 16891.25 Da
• Isoelectric Point: 5.6376

>T237979 WP_133599790.1 NZ_CP093276:3058637-3059098 [Raoultella sp. HC6]
VILYRLTKTRFLTTAWSGFGAKEAGGRWNSVGTAMVYLSEAASLTMLETLVHINAPQLLDDFTLLSIDVPDDQVLTVDPH
SLPADWAREDAPARLARYGDEWAASAASAALRVPSALSPVEYNYLFNPQHPAVFDLLASVKRIPFRFDTRLKA

Nucleotide

• Length: 462 bp

>T237979 NZ_LR883965:258442-258545 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 148 a.a.
• Molecular weight: 16310.57 Da
• Isoelectric Point: 6.7345

>AT237979 WP_045855354.1 NZ_CP093276:3058197-3058640 [Raoultella sp. HC6]
MKVYSPTESAEKNLSPWHAIGLDAEDGIALMGKISHGLEGSVARQISAWAEITPAELRKMSGIANTTFNRSIKSRFSADQ
SERLVRILRVIERAVELFEGDKEAAQKWMNEPNRALGWKTPAEVVSSETGALEVMRLITRVEHGVYS

Nucleotide

• Length: 444 bp

>AT237979 NZ_LR883965:c258583-258312 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Structures

Antitoxin

• AlphaFold DB: A0A8B4Z103