Detailed information of TA system TA237970

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 919309..919966
• Replicon: chromosome
• Accession: NZ_CP093276
• Organism: Raoultella sp. HC6

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: MMW58_RS04520
• Protein ID: WP_133600550.1
• Coordinates: 919556..919966 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A8B4YXS2
• Locus tag: MMW58_RS04515
• Protein ID: WP_045857153.1
• Coordinates: 919309..919575 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MMW58_RS04490	914385..915818	-	1434	WP_241722788.1	6-phospho-beta-glucosidase	-
MMW58_RS04495	915939..916667	-	729	WP_045857150.1	MurR/RpiR family transcriptional regulator	-
MMW58_RS04500	916717..917028	+	312	WP_133600553.1	N(4)-acetylcytidine aminohydrolase	-
MMW58_RS04505	917189..917848	+	660	WP_133600552.1	hemolysin III family protein	-
MMW58_RS04510	917955..918938	-	984	WP_241722789.1	tRNA-modifying protein YgfZ	-
MMW58_RS04515	919309..919575	+	267	WP_045857153.1	FAD assembly factor SdhE	Antitoxin
MMW58_RS04520	919556..919966	+	411	WP_133600550.1	protein YgfX	Toxin
MMW58_RS04525	919997..920518	-	522	WP_045857157.1	flavodoxin FldB	-
MMW58_RS04530	920677..921573	+	897	WP_133600549.1	site-specific tyrosine recombinase XerD	-
MMW58_RS04535	921597..922310	+	714	WP_045857161.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
MMW58_RS04540	922316..924049	+	1734	WP_241722790.1	single-stranded-DNA-specific exonuclease RecJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 16121.02 Da
• Isoelectric Point: 11.0696

>T237970 WP_133600550.1 NZ_CP093276:919556-919966 [Raoultella sp. HC6]
VVLWQSDLRISWRSQWFSLLLHGVVAAIVLLMPWPLSYTPLWLLLLSLVVFDCVRSQRRIHACQGEIKLLTDSRLRWQKA
EWEIVGMPWVINSGMLLRLRHTQTRRSQHLWVAADSMDAKEWRDLRRLVLNKPAQD

Nucleotide

• Length: 411 bp

>T237970 NZ_LR883050:c4392487-4392314 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10569.04 Da
• Isoelectric Point: 4.8432

>AT237970 WP_045857153.1 NZ_CP093276:919309-919575 [Raoultella sp. HC6]
MDITNKARIHWACRRGMRELDISIMPFFEYEYDTLSDEDKQLFIRLLENDDPDLFNWLMNHGEPSDAQLQRMVKLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT237970 NZ_LR883050:c4392811-4392515 [Escherichia coli]
ATGGAAGGTAAAAACAGGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCTTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Structures

Antitoxin

• AlphaFold DB: A0A8B4YXS2