Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 758964..759717 | Replicon | chromosome |
| Accession | NZ_CP093276 | ||
| Organism | Raoultella sp. HC6 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | R8WN26 |
| Locus tag | MMW58_RS03700 | Protein ID | WP_016154457.1 |
| Coordinates | 758964..759341 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | - |
| Locus tag | MMW58_RS03705 | Protein ID | WP_162838704.1 |
| Coordinates | 759391..759717 (-) | Length | 109 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MMW58_RS03665 | 754821..755084 | - | 264 | WP_075912842.1 | immunity protein | - |
| MMW58_RS03670 | 755166..755309 | - | 144 | Protein_720 | tail fiber domain-containing protein | - |
| MMW58_RS03675 | 755909..756774 | - | 866 | Protein_721 | site-specific integrase | - |
| MMW58_RS03680 | 757069..757305 | - | 237 | WP_016154458.1 | hypothetical protein | - |
| MMW58_RS03685 | 757317..758162 | - | 846 | Protein_723 | DUF4942 domain-containing protein | - |
| MMW58_RS03690 | 758243..758446 | - | 204 | WP_009652505.1 | DUF957 domain-containing protein | - |
| MMW58_RS03695 | 758476..758967 | - | 492 | WP_009652438.1 | DUF5983 family protein | - |
| MMW58_RS03700 | 758964..759341 | - | 378 | WP_016154457.1 | TA system toxin CbtA family protein | Toxin |
| MMW58_RS03705 | 759391..759717 | - | 327 | WP_162838704.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| MMW58_RS03710 | 759774..759995 | - | 222 | WP_009652392.1 | DUF987 domain-containing protein | - |
| MMW58_RS03715 | 760009..760491 | - | 483 | WP_016154455.1 | DNA repair protein RadC | - |
| MMW58_RS03720 | 760503..760721 | - | 219 | WP_009652503.1 | hypothetical protein | - |
| MMW58_RS03725 | 760732..761205 | - | 474 | WP_009652453.1 | antirestriction protein | - |
| MMW58_RS03730 | 761222..761476 | - | 255 | WP_009652519.1 | hypothetical protein | - |
| MMW58_RS03735 | 761476..762294 | - | 819 | WP_009652424.1 | DUF932 domain-containing protein | - |
| MMW58_RS03740 | 762398..762631 | - | 234 | WP_009652474.1 | DUF905 domain-containing protein | - |
| MMW58_RS03745 | 762687..762908 | - | 222 | WP_009652443.1 | hypothetical protein | - |
| MMW58_RS03750 | 762991..763503 | - | 513 | WP_009652395.1 | DUF4234 domain-containing protein | - |
| MMW58_RS03755 | 763552..764022 | - | 471 | WP_009652431.1 | hypothetical protein | - |
| MMW58_RS03760 | 764069..764380 | - | 312 | WP_009652410.1 | hypothetical protein | - |
| MMW58_RS03765 | 764393..764659 | - | 267 | WP_009652486.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 744718..767260 | 22542 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14168.19 Da Isoelectric Point: 9.5224
>T237969 WP_016154457.1 NZ_CP093276:c759341-758964 [Raoultella sp. HC6]
MQTQPVPPKREVSPRPSPVAIWQRLLSHLLDRHYGLTLNDTPFGKDGVIQEHIDAGISLCDAVNFIVEKYDLVRTDRRGF
NAETQSPLLTSIDILRARKATGLMTRHSYRAVTDITTGKYREVQP
MQTQPVPPKREVSPRPSPVAIWQRLLSHLLDRHYGLTLNDTPFGKDGVIQEHIDAGISLCDAVNFIVEKYDLVRTDRRGF
NAETQSPLLTSIDILRARKATGLMTRHSYRAVTDITTGKYREVQP
Download Length: 378 bp
>T237969 NZ_LR883050:4380647-4381024 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGCTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACCGAACGGTAAATAACATTACCCAGGGTAAGCATCCGGAGGCGAAACGATGA
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGCTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACCGAACGGTAAATAACATTACCCAGGGTAAGCATCCGGAGGCGAAACGATGA
Antitoxin
Download Length: 109 a.a. Molecular weight: 12079.85 Da Isoelectric Point: 6.6283
>AT237969 WP_162838704.1 NZ_CP093276:c759717-759391 [Raoultella sp. HC6]
IAAPWWGLKRDITPCFGARLVQEGNRLHYLNDRASITGTFSDADLRHLDQAFPLLLKQLELMLLSGELNPRHQHCVTLYA
KGLICEADSLGSHGYVYLAIYPTPATTE
IAAPWWGLKRDITPCFGARLVQEGNRLHYLNDRASITGTFSDADLRHLDQAFPLLLKQLELMLLSGELNPRHQHCVTLYA
KGLICEADSLGSHGYVYLAIYPTPATTE
Download Length: 327 bp
>AT237969 NZ_LR883050:4380226-4380600 [Escherichia coli]
GTGTCAGACACACTCCATAAGACAAATTATCCCGACGACAACAACGACCGCCCCTGGTGGGGGCTCCCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCTGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA
GTGTCAGACACACTCCATAAGACAAATTATCCCGACGACAACAACGACCGCCCCTGGTGGGGGCTCCCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCTGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|