Detailed information of TA system TA237967

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX(toxin)
• Location: 4711155..4711974
• Replicon: chromosome
• Accession: NZ_CP093271
• Organism: Klebsiella oxytoca strain C-21-18

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: J5WT09
• Locus tag: MN553_RS22360
• Protein ID: WP_004110819.1
• Coordinates: 4711717..4711974 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: MN553_RS22355
• Protein ID: WP_004099227.1
• Coordinates: 4711155..4711706 (-)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MN553_RS22335 (MN553_22335)	4706484..4707881	+	1398	WP_077257937.1	MFS transporter	-
MN553_RS22340 (MN553_22340)	4708005..4709345	+	1341	WP_024273771.1	carbohydrate porin	-
MN553_RS22345 (MN553_22345)	4709509..4710273	-	765	WP_224239836.1	class I SAM-dependent methyltransferase	-
MN553_RS22350 (MN553_22350)	4710667..4711041	-	375	Protein_4405	class I SAM-dependent methyltransferase	-
MN553_RS22355 (MN553_22355)	4711155..4711706	-	552	WP_004099227.1	N-acetyltransferase	Antitoxin
MN553_RS22360 (MN553_22360)	4711717..4711974	-	258	WP_004110819.1	YjhX family toxin	Toxin
MN553_RS22365 (MN553_22365)	4712557..4713741	+	1185	WP_049593480.1	mannonate dehydratase	-
MN553_RS22370 (MN553_22370)	4713816..4715291	+	1476	WP_004110817.1	fructuronate reductase	-
MN553_RS22375 (MN553_22375)	4715427..4716203	+	777	WP_017146569.1	Uxu operon transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (17-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9552.07 Da
• Isoelectric Point: 11.1381

>T237967 WP_004110819.1 NZ_CP093271:c4711974-4711717 [Klebsiella oxytoca]
MNLSRQEQRTLHVLAKGGRIAHIRDASGRVTSVECYSREGLLLSDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T237967 NZ_LR883050:c3758944-3758546 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACAGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20246.21 Da
• Isoelectric Point: 6.7178

>AT237967 WP_004099227.1 NZ_CP093271:c4711706-4711155 [Klebsiella oxytoca]
MTNHNFTFHITSERDADDIREVETRAFGFSKEADLVADLLNDESAHPRLSLLAKHNGKAVGHILFTLATFKGESDSPMMH
ILAPLAVVPEYQGMGVGGLLIQSGIEHLKAMGSLAVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMLQRLSS
RPLGITGQIQCARALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT237967 NZ_LR883050:c3759240-3758947 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATTACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGAGCA
GAAAAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Structures

Toxin

• AlphaFold DB: A0A0H3H6Y2