Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 899013..899670 Replicon chromosome
Accession NZ_CP093271
Organism Klebsiella oxytoca strain C-21-18

Toxin (Protein)


Gene name cptA Uniprot ID A0A181X6I0
Locus tag MN553_RS04390 Protein ID WP_004105559.1
Coordinates 899260..899670 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A285B945
Locus tag MN553_RS04385 Protein ID WP_004105561.1
Coordinates 899013..899279 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MN553_RS04360 (MN553_04360) 894193..895626 - 1434 WP_049128113.1 6-phospho-beta-glucosidase -
MN553_RS04365 (MN553_04365) 895747..896475 - 729 WP_075551476.1 MurR/RpiR family transcriptional regulator -
MN553_RS04370 (MN553_04370) 896526..896837 + 312 WP_004105571.1 N(4)-acetylcytidine aminohydrolase -
MN553_RS04375 (MN553_04375) 896999..897658 + 660 WP_004105569.1 hemolysin III family protein -
MN553_RS04380 (MN553_04380) 897786..898769 - 984 WP_004115279.1 tRNA-modifying protein YgfZ -
MN553_RS04385 (MN553_04385) 899013..899279 + 267 WP_004105561.1 FAD assembly factor SdhE Antitoxin
MN553_RS04390 (MN553_04390) 899260..899670 + 411 WP_004105559.1 protein YgfX Toxin
MN553_RS04395 (MN553_04395) 899679..900200 - 522 WP_004105557.1 flavodoxin FldB -
MN553_RS04400 (MN553_04400) 900322..901218 + 897 WP_004105555.1 site-specific tyrosine recombinase XerD -
MN553_RS04405 (MN553_04405) 901241..901954 + 714 WP_024274699.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
MN553_RS04410 (MN553_04410) 901960..903693 + 1734 WP_024274698.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16061.83 Da        Isoelectric Point: 10.9455

>T237957 WP_004105559.1 NZ_CP093271:899260-899670 [Klebsiella oxytoca]
VVLWQSDLRISWRAQWFSLLMHGVVAALVLVLPWPLSYTPLWLILLSLVVFDCVRSQRRIHARQGEIKLLIDSRLRWQKA
EWDIVGTPWVINSGMLLRLRNTENQRTQHLWVAADSMDAGEWRDLRRLVLQKPTQD

Download         Length: 411 bp

>T237957 NZ_LR883050:703481-703795 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10555.02 Da        Isoelectric Point: 5.1498

>AT237957 WP_004105561.1 NZ_CP093271:899013-899279 [Klebsiella oxytoca]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDDDKRLFIRLLENDDPDLFNWLMNHGEPADAELQRMVKLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT237957 NZ_LR883050:703792-704208 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A181X6I0

Antitoxin

Source ID Structure
AlphaFold DB A0A285B945

References