Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 90924..91501 Replicon plasmid pW17-3-a
Accession NZ_CP093261
Organism Moellerella wisconsensis strain W17-3

Toxin (Protein)


Gene name mazF Uniprot ID U5N651
Locus tag MNY68_RS16250 Protein ID WP_023159957.1
Coordinates 91169..91501 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID U5N340
Locus tag MNY68_RS16245 Protein ID WP_023159984.1
Coordinates 90924..91169 (+) Length 82 a.a.

Genomic Context

MNY68_RS16205MNY68_RS16210MNY68_RS16215MNY68_RS16220MNY68_RS16225MNY68_RS16230MNY68_RS16245MNY68_RS16250MNY68_RS16255MNY68_RS16280MNY68_RS16355MNY68_RS16285MNY68_RS16235MNY68_RS16240MNY68_RS16260MNY68_RS16265MNY68_RS16270MNY68_RS16275
Location: 85937..86281 (345 bp)
Type: Others
Protein ID: WP_023159966.1
Location: 86274..86696 (423 bp)
Type: Others
Protein ID: WP_048821775.1
Location: 86706..87098 (393 bp)
Type: Others
Protein ID: WP_048821774.1
Location: 87379..87858 (480 bp)
Type: Others
Protein ID: WP_048821772.1
Location: 87867..88445 (579 bp)
Type: Others
Protein ID: WP_048822182.1
Location: 89206..89574 (369 bp)
Type: Others
Protein ID: WP_048821769.1
Location: 90924..91169 (246 bp)
Type: Antitoxin
Protein ID: WP_023159984.1
Location: 91169..91501 (333 bp)
Type: Toxin
Protein ID: WP_023159957.1
Location: 91532..91912 (381 bp)
Type: Others
Protein ID: WP_048821763.1
Location: 93874..94827 (954 bp)
Type: Others
Protein ID: WP_048821757.1
Location: 94843..94977 (135 bp)
Type: Others
Protein ID: WP_256326490.1
Location: 95096..95917 (822 bp)
Type: Others
Protein ID: WP_001029679.1
Location: 89672..89899 (228 bp)
Type: Others
Protein ID: WP_048821767.1
Location: 90008..90631 (624 bp)
Type: Others
Protein ID: WP_023159958.1
Location: 92001..92141 (141 bp)
Type: Others
Protein ID: WP_072022937.1
Location: 92461..92919 (459 bp)
Type: Others
Protein ID: WP_048821762.1
Location: 93018..93272 (255 bp)
Type: Others
Protein ID: WP_048821760.1
Location: 93311..93580 (270 bp)
Type: Others
Protein ID: WP_048821758.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
MNY68_RS16205 (MNY68_16205)85937..86281+345WP_023159966.1single-stranded DNA-binding protein-
MNY68_RS16210 (MNY68_16210)86274..86696+423WP_048821775.1hypothetical protein-
MNY68_RS16215 (MNY68_16215)86706..87098+393WP_048821774.1hypothetical protein-
MNY68_RS16220 (MNY68_16220)87379..87858+480WP_048821772.1Hcp family type VI secretion system effector-
MNY68_RS16225 (MNY68_16225)87867..88445+579WP_048822182.1hypothetical protein-
MNY68_RS16230 (MNY68_16230)89206..89574+369WP_048821769.1hypothetical protein-
MNY68_RS16235 (MNY68_16235)89672..89899-228WP_048821767.1plasmid partition protein ParG-
MNY68_RS16240 (MNY68_16240)90008..90631-624WP_023159958.1AAA family ATPase-
MNY68_RS16245 (MNY68_16245)90924..91169+246WP_023159984.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
MNY68_RS16250 (MNY68_16250)91169..91501+333WP_023159957.1endoribonuclease MazFToxin
MNY68_RS16255 (MNY68_16255)91532..91912+381WP_048821763.1hypothetical protein-
MNY68_RS16260 (MNY68_16260)92001..92141-141WP_072022937.1Hok/Gef family protein-
MNY68_RS16265 (MNY68_16265)92461..92919-459WP_048821762.1hypothetical protein-
MNY68_RS16270 (MNY68_16270)93018..93272-255WP_048821760.1hypothetical protein-
MNY68_RS16275 (MNY68_16275)93311..93580-270WP_048821758.1hypothetical protein-
MNY68_RS16280 (MNY68_16280)93874..94827+954WP_048821757.1site-specific integrase-
MNY68_RS1635594843..94977+135WP_256326490.1hypothetical protein-
MNY68_RS16285 (MNY68_16285)95096..95917+822WP_001029679.1TnsA endonuclease N-terminal domain-containing protein-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmidblaCTX-M-32 / aph(3')-Ia / sul1 / qacE / ant(3'')-Ia / dfrA1 / lnu(F)-1..102837102837


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(9-107)

Antitoxin

SpoVT-AbrB domain

(7-49)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12097.88 Da        Isoelectric Point: 7.0813

>T237955 WP_023159957.1 NZ_CP093261:91169-91501 [Moellerella wisconsensis]
MVSRYVPDSGDLIWIDFDPVEGHEQGGHRPAVVLSPFAYNNKVGLLLCVPCTTKGKGYPFECELSNERDSYALADQVTCV
DWRARKVTKKGKVEASELAEIKAKAKALIG

Download         Length: 333 bp

>T237955 NZ_LR883050:208590-208697 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8786.20 Da        Isoelectric Point: 5.0351

>AT237955 WP_023159984.1 NZ_CP093261:90924-91169 [Moellerella wisconsensis]
MAQVTVKKWGNSPSVRLPVAIMQKAALSVDDTVEIAVEEGRIIITPVKAVEYSLDNLLAGITPENIHEKVDFGARTGKEL
I

Download         Length: 246 bp

>AT237955 NZ_LR883050:c208542-208476 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A2P1BQ75

Antitoxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A857E7M9

References