Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2873405..2874044 Replicon chromosome
Accession NZ_CP093260
Organism Moellerella wisconsensis strain W17-3

Toxin (Protein)


Gene name Hha Uniprot ID -
Locus tag MNY68_RS12760 Protein ID WP_269430900.1
Coordinates 2873820..2874044 (+) Length 75 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag MNY68_RS12755 Protein ID WP_241540560.1
Coordinates 2873405..2873773 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNY68_RS12730 (MNY68_12730) 2868606..2869367 - 762 WP_047256407.1 DNA polymerase III subunit epsilon -
MNY68_RS12735 (MNY68_12735) 2869424..2869891 + 468 WP_047256408.1 ribonuclease HI -
MNY68_RS12740 (MNY68_12740) 2869894..2870610 - 717 WP_047256409.1 methyltransferase domain-containing protein -
MNY68_RS12745 (MNY68_12745) 2870645..2871400 + 756 WP_241541332.1 hydroxyacylglutathione hydrolase -
MNY68_RS12750 (MNY68_12750) 2871472..2872827 + 1356 WP_047256411.1 murein transglycosylase D -
MNY68_RS12755 (MNY68_12755) 2873405..2873773 + 369 WP_241540560.1 Hha toxicity modulator TomB Antitoxin
MNY68_RS12760 (MNY68_12760) 2873820..2874044 + 225 WP_269430900.1 HHA domain-containing protein Toxin
MNY68_RS12770 (MNY68_12770) 2874817..2875278 - 462 WP_047256414.1 YbaY family lipoprotein -
MNY68_RS12775 (MNY68_12775) 2875675..2876538 + 864 WP_241501033.1 acyl-CoA thioesterase II -
MNY68_RS12780 (MNY68_12780) 2877603..2878886 - 1284 WP_241541333.1 ammonium transporter AmtB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2863500..2888263 24763


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(15-71)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 75 a.a.        Molecular weight: 8977.32 Da        Isoelectric Point: 5.8622

>T237953 WP_269430900.1 NZ_CP093260:2873820-2874044 [Moellerella wisconsensis]
MNERQENMTKTDYLMRLRKCTTIETLERVIEKNKYELSDDELELFFSAADHRLAELTMNKLYDKIPASVWKYVR

Download         Length: 225 bp

>T237953 NZ_LR883014:c61409-61251 [Escherichia coli]
ATGAAACTACCACGAAGTTCCCTTGTCTGGTGTGTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGACACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14419.25 Da        Isoelectric Point: 4.5817

>AT237953 WP_241540560.1 NZ_CP093260:2873405-2873773 [Moellerella wisconsensis]
MDEYSPRYYDTAELKYLCDSLNNDAILSLHKTKTHWINDLSSQQSTNLNELIEHVAAFFWKFKIKYPSERLFISLVDEYL
DETYNLFGSPLITLNEFSDWQKMNTHLIDELNNDLKCSVAKL

Download         Length: 369 bp

>AT237953 NZ_LR883014:c61668-61474 [Escherichia coli]
TCACGCGGATTTCCCGTAGCCTGAATGAGCGTATTCTTTTCAGGAAAAGTGAATGTGGCCAGCGTGCAGGGATATGAGCT
ATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTACCGTGTTGTGTGGCAGAAGGCAGAA
AGCCCCGTAGTTAATTTTTCATTAACCCACGAGGC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References