Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2933448..2934087 Replicon chromosome
Accession NZ_CP093249
Organism Moellerella wisconsensis strain W18-2

Toxin (Protein)


Gene name Hha Uniprot ID -
Locus tag MNY64_RS13020 Protein ID WP_269430900.1
Coordinates 2933863..2934087 (+) Length 75 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag MNY64_RS13015 Protein ID WP_047256412.1
Coordinates 2933448..2933816 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNY64_RS12990 (MNY64_12995) 2928649..2929410 - 762 WP_047256407.1 DNA polymerase III subunit epsilon -
MNY64_RS12995 (MNY64_13000) 2929467..2929934 + 468 WP_047256408.1 ribonuclease HI -
MNY64_RS13000 (MNY64_13005) 2929937..2930653 - 717 WP_047256409.1 methyltransferase domain-containing protein -
MNY64_RS13005 (MNY64_13010) 2930688..2931443 + 756 WP_047256410.1 hydroxyacylglutathione hydrolase -
MNY64_RS13010 (MNY64_13015) 2931515..2932870 + 1356 WP_047256411.1 murein transglycosylase D -
MNY64_RS13015 (MNY64_13020) 2933448..2933816 + 369 WP_047256412.1 Hha toxicity modulator TomB Antitoxin
MNY64_RS13020 (MNY64_13025) 2933863..2934087 + 225 WP_269430900.1 HHA domain-containing protein Toxin
MNY64_RS13030 (MNY64_13035) 2934873..2935334 - 462 WP_047256414.1 YbaY family lipoprotein -
MNY64_RS13035 (MNY64_13040) 2935731..2936594 + 864 WP_241501033.1 acyl-CoA thioesterase II -
MNY64_RS13040 (MNY64_13045) 2937659..2938942 - 1284 WP_047256416.1 ammonium transporter AmtB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2923543..2948320 24777


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(15-71)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 75 a.a.        Molecular weight: 8977.32 Da        Isoelectric Point: 5.8622

>T237938 WP_269430900.1 NZ_CP093249:2933863-2934087 [Moellerella wisconsensis]
MNERQENMTKTDYLMRLRKCTTIETLERVIEKNKYELSDDELELFFSAADHRLAELTMNKLYDKIPASVWKYVR

Download         Length: 225 bp

>T237938 NZ_LR883012:938530-938937 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATCCACGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGACGCATTAATGCTCGCCAGGGAGAAATTCGCCTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14371.20 Da        Isoelectric Point: 4.5817

>AT237938 WP_047256412.1 NZ_CP093249:2933448-2933816 [Moellerella wisconsensis]
MDEYSPRYYDTAELKYLCDSLNNDAILSLHKTKTHWINDLSSQQSTNLNELIEHVAAFFWKFKIKYPSERLVISLVDEYL
DETYNLFGSPLITLNEFSDWQKMNTHLIDELNNDLKCSVAKL

Download         Length: 369 bp

>AT237938 NZ_LR883012:938283-938549 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCCGATC
TGTTCAACTGGCTGATGAATCATGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References