Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | Hha-TomB/- |
| Location | 2933448..2934087 | Replicon | chromosome |
| Accession | NZ_CP093249 | ||
| Organism | Moellerella wisconsensis strain W18-2 | ||
Toxin (Protein)
| Gene name | Hha | Uniprot ID | - |
| Locus tag | MNY64_RS13020 | Protein ID | WP_269430900.1 |
| Coordinates | 2933863..2934087 (+) | Length | 75 a.a. |
Antitoxin (Protein)
| Gene name | TomB | Uniprot ID | - |
| Locus tag | MNY64_RS13015 | Protein ID | WP_047256412.1 |
| Coordinates | 2933448..2933816 (+) | Length | 123 a.a. |
Genomic Context
Location: 2929467..2929934 (468 bp)
Type: Others
Protein ID: WP_047256408.1
Type: Others
Protein ID: WP_047256408.1
Location: 2930688..2931443 (756 bp)
Type: Others
Protein ID: WP_047256410.1
Type: Others
Protein ID: WP_047256410.1
Location: 2931515..2932870 (1356 bp)
Type: Others
Protein ID: WP_047256411.1
Type: Others
Protein ID: WP_047256411.1
Location: 2933448..2933816 (369 bp)
Type: Antitoxin
Protein ID: WP_047256412.1
Type: Antitoxin
Protein ID: WP_047256412.1
Location: 2933863..2934087 (225 bp)
Type: Toxin
Protein ID: WP_269430900.1
Type: Toxin
Protein ID: WP_269430900.1
Location: 2935731..2936594 (864 bp)
Type: Others
Protein ID: WP_241501033.1
Type: Others
Protein ID: WP_241501033.1
Location: 2928649..2929410 (762 bp)
Type: Others
Protein ID: WP_047256407.1
Type: Others
Protein ID: WP_047256407.1
Location: 2929937..2930653 (717 bp)
Type: Others
Protein ID: WP_047256409.1
Type: Others
Protein ID: WP_047256409.1
Location: 2934873..2935334 (462 bp)
Type: Others
Protein ID: WP_047256414.1
Type: Others
Protein ID: WP_047256414.1
Location: 2937659..2938942 (1284 bp)
Type: Others
Protein ID: WP_047256416.1
Type: Others
Protein ID: WP_047256416.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MNY64_RS12990 (MNY64_12995) | 2928649..2929410 | - | 762 | WP_047256407.1 | DNA polymerase III subunit epsilon | - |
| MNY64_RS12995 (MNY64_13000) | 2929467..2929934 | + | 468 | WP_047256408.1 | ribonuclease HI | - |
| MNY64_RS13000 (MNY64_13005) | 2929937..2930653 | - | 717 | WP_047256409.1 | methyltransferase domain-containing protein | - |
| MNY64_RS13005 (MNY64_13010) | 2930688..2931443 | + | 756 | WP_047256410.1 | hydroxyacylglutathione hydrolase | - |
| MNY64_RS13010 (MNY64_13015) | 2931515..2932870 | + | 1356 | WP_047256411.1 | murein transglycosylase D | - |
| MNY64_RS13015 (MNY64_13020) | 2933448..2933816 | + | 369 | WP_047256412.1 | Hha toxicity modulator TomB | Antitoxin |
| MNY64_RS13020 (MNY64_13025) | 2933863..2934087 | + | 225 | WP_269430900.1 | HHA domain-containing protein | Toxin |
| MNY64_RS13030 (MNY64_13035) | 2934873..2935334 | - | 462 | WP_047256414.1 | YbaY family lipoprotein | - |
| MNY64_RS13035 (MNY64_13040) | 2935731..2936594 | + | 864 | WP_241501033.1 | acyl-CoA thioesterase II | - |
| MNY64_RS13040 (MNY64_13045) | 2937659..2938942 | - | 1284 | WP_047256416.1 | ammonium transporter AmtB | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2923543..2948320 | 24777 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 75 a.a. Molecular weight: 8977.32 Da Isoelectric Point: 5.8622
>T237938 WP_269430900.1 NZ_CP093249:2933863-2934087 [Moellerella wisconsensis]
MNERQENMTKTDYLMRLRKCTTIETLERVIEKNKYELSDDELELFFSAADHRLAELTMNKLYDKIPASVWKYVR
MNERQENMTKTDYLMRLRKCTTIETLERVIEKNKYELSDDELELFFSAADHRLAELTMNKLYDKIPASVWKYVR
Download Length: 225 bp
>T237938 NZ_LR883012:938530-938937 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATCCACGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGACGCATTAATGCTCGCCAGGGAGAAATTCGCCTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATCCACGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGACGCATTAATGCTCGCCAGGGAGAAATTCGCCTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA
Antitoxin
Download Length: 123 a.a. Molecular weight: 14371.20 Da Isoelectric Point: 4.5817
>AT237938 WP_047256412.1 NZ_CP093249:2933448-2933816 [Moellerella wisconsensis]
MDEYSPRYYDTAELKYLCDSLNNDAILSLHKTKTHWINDLSSQQSTNLNELIEHVAAFFWKFKIKYPSERLVISLVDEYL
DETYNLFGSPLITLNEFSDWQKMNTHLIDELNNDLKCSVAKL
MDEYSPRYYDTAELKYLCDSLNNDAILSLHKTKTHWINDLSSQQSTNLNELIEHVAAFFWKFKIKYPSERLVISLVDEYL
DETYNLFGSPLITLNEFSDWQKMNTHLIDELNNDLKCSVAKL
Download Length: 369 bp
>AT237938 NZ_LR883012:938283-938549 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCCGATC
TGTTCAACTGGCTGATGAATCATGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCCGATC
TGTTCAACTGGCTGATGAATCATGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA